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The map label for this gene is aceA [H]

Identifier: 121610032

GI number: 121610032

Start: 3437796

End: 3439127

Strand: Direct

Name: aceA [H]

Synonym: Veis_3088

Alternate gene names: 121610032

Gene position: 3437796-3439127 (Clockwise)

Preceding gene: 121610031

Following gene: 121610033

Centisome position: 61.76

GC content: 63.14

Gene sequence:

>1332_bases
ATGCCCCAATCCCTGAACGAACAACTCAGCCGCGAGCAGCAAATCGCCGCGCTGGAAAAAAATTGGGCCCAGGCCCCGCG
CTGGAAGGGCGTCAAGCGCGGCTACGGCGCCGCTGATGTGGTGCGCCTGCGCGGCAGCTTGCAGCCGGAGCACACGCTGG
CCCAGCGCGGTGCGGAAAAGCTGTGGGACAAGATCAACGGCGGCGCCAAAAAGGGCTACGTGAACGCATTCGGCGCCATC
TCTGCCGGGCAGGCCATGCAGCAAGCCAAGGCCGGTCTGGAAGCCGTGTACCTGTCGGGCTGGCAAGTGGCCGCCGACGG
CAACACTTCGGAAACCATGTACCCCGACCAGTCGCTGTACGCCTACGACTCGGTGCCCGCGATGGTCCGCCGCATCAACA
ACACCTTCAAGCGCGCTGACGAAATTCAGTGGGGCCGTGGCGTCAACCCCGGCGACAAGGAGTTCATCGACTATTTCCTG
CCCATCGTGGCAGACGCCGAGGCCGGCTTTGGCGGCGTGCTCAACGCCTTCGAGTTGATGAAGAACATGATCAGCGCCGG
CGCTGCCGGTGTTCACTTCGAGGACCAGTTGGCGGCCGTGAAGAAATGCGGCCACATGGGTGGCAAGGTGCTGGTGCCCA
CGCAGGAAGCCTGCGAAAAGCTGATCGCGGCGCGCTTTGCGGCCGACGTGATGGGCGTGTCGACCATCGTGCTGGCCCGC
ACCGATGCCGAAGCCGCCAACCTGGTCACGTCCGACCATGACGCGAACGACAGGCCCTTTCTGACCGGCGAACGCACGCA
GGAAGGCTTTTACCGCGTCAAGAACGGGCTGGAGCAAGCCATCAGCCGTGGCGTCGCCTACGCTCCTTACGCCGACCTGG
TGTGGTGCGAAACCGGTGTGCCGGACATCGGCTTTGCCCGTGAATTCGCCCAGGCTGTGCACGCAGCATGCCCGGGCAAG
CTGCTGTCGTACAACTGCTCGCCGTCCTTCAACTGGAAGAAGAACTTGAACGACCAGCAGATCGCCTCCTTTCAGGACGA
ACTGTCGGCCCTGGGCTACAAGTTCCAGTTCATCACGCTGGCCGGCATCCATATCAACTGGTTCAACACCTTCGAGTTCG
CCCATGCCTACGCCCGTGGCGAAGGCATGAAGCACTACACCGATATGGTGCAGGAGCCGGAATTCGCCGCCCGCGAAAAG
GGCTACAGCTTCGTGTCGCACCAGCAGGAGGTGGGCGCAGGCTACTTCGATGACGTGACCACCGTGATCCAGGGCGGCTC
CTCCAGCGTGAAGGCGCTGACCGGCTCGACCGAAGAGCAACAGTTCCACTGA

Upstream 100 bases:

>100_bases
AGACATAAGAGCTTGTGCAACTCTTATAGAAGACTTAAAGTCCTCTCCAAGGGCGGCATGCAGCAGCCCGGTGTTTCCAA
CCTACCTCTGGAGTGATCCC

Downstream 100 bases:

>100_bases
GCCAAAGCCTGGCGCTCGTTGCCGCAATCTGTGGTGAGCAACGCAGCCAAAGGGTGGCCCGACAAGCCCCGGGCGGATGC
CTGGGGCGCGGGAAGTGGCC

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MPQSLNEQLSREQQIAALEKNWAQAPRWKGVKRGYGAADVVRLRGSLQPEHTLAQRGAEKLWDKINGGAKKGYVNAFGAI
SAGQAMQQAKAGLEAVYLSGWQVAADGNTSETMYPDQSLYAYDSVPAMVRRINNTFKRADEIQWGRGVNPGDKEFIDYFL
PIVADAEAGFGGVLNAFELMKNMISAGAAGVHFEDQLAAVKKCGHMGGKVLVPTQEACEKLIAARFAADVMGVSTIVLAR
TDAEAANLVTSDHDANDRPFLTGERTQEGFYRVKNGLEQAISRGVAYAPYADLVWCETGVPDIGFAREFAQAVHAACPGK
LLSYNCSPSFNWKKNLNDQQIASFQDELSALGYKFQFITLAGIHINWFNTFEFAHAYARGEGMKHYTDMVQEPEFAAREK
GYSFVSHQQEVGAGYFDDVTTVIQGGSSSVKALTGSTEEQQFH

Sequences:

>Translated_443_residues
MPQSLNEQLSREQQIAALEKNWAQAPRWKGVKRGYGAADVVRLRGSLQPEHTLAQRGAEKLWDKINGGAKKGYVNAFGAI
SAGQAMQQAKAGLEAVYLSGWQVAADGNTSETMYPDQSLYAYDSVPAMVRRINNTFKRADEIQWGRGVNPGDKEFIDYFL
PIVADAEAGFGGVLNAFELMKNMISAGAAGVHFEDQLAAVKKCGHMGGKVLVPTQEACEKLIAARFAADVMGVSTIVLAR
TDAEAANLVTSDHDANDRPFLTGERTQEGFYRVKNGLEQAISRGVAYAPYADLVWCETGVPDIGFAREFAQAVHAACPGK
LLSYNCSPSFNWKKNLNDQQIASFQDELSALGYKFQFITLAGIHINWFNTFEFAHAYARGEGMKHYTDMVQEPEFAAREK
GYSFVSHQQEVGAGYFDDVTTVIQGGSSSVKALTGSTEEQQFH
>Mature_442_residues
PQSLNEQLSREQQIAALEKNWAQAPRWKGVKRGYGAADVVRLRGSLQPEHTLAQRGAEKLWDKINGGAKKGYVNAFGAIS
AGQAMQQAKAGLEAVYLSGWQVAADGNTSETMYPDQSLYAYDSVPAMVRRINNTFKRADEIQWGRGVNPGDKEFIDYFLP
IVADAEAGFGGVLNAFELMKNMISAGAAGVHFEDQLAAVKKCGHMGGKVLVPTQEACEKLIAARFAADVMGVSTIVLART
DAEAANLVTSDHDANDRPFLTGERTQEGFYRVKNGLEQAISRGVAYAPYADLVWCETGVPDIGFAREFAQAVHAACPGKL
LSYNCSPSFNWKKNLNDQQIASFQDELSALGYKFQFITLAGIHINWFNTFEFAHAYARGEGMKHYTDMVQEPEFAAREKG
YSFVSHQQEVGAGYFDDVTTVIQGGSSSVKALTGSTEEQQFH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=71.5935334872979, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI1786525, Length=264, Percent_Identity=28.4090909090909, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17561814, Length=420, Percent_Identity=54.047619047619, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71982926, Length=423, Percent_Identity=53.6643026004728, Blast_Score=450, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6320908, Length=291, Percent_Identity=37.4570446735395, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325263, Length=248, Percent_Identity=35.8870967741936, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 48489; Mature: 48358

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSLNEQLSREQQIAALEKNWAQAPRWKGVKRGYGAADVVRLRGSLQPEHTLAQRGAEK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHH
LWDKINGGAKKGYVNAFGAISAGQAMQQAKAGLEAVYLSGWQVAADGNTSETMYPDQSLY
HHHHHCCCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCCCCCCEE
AYDSVPAMVRRINNTFKRADEIQWGRGVNPGDKEFIDYFLPIVADAEAGFGGVLNAFELM
EHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KNMISAGAAGVHFEDQLAAVKKCGHMGGKVLVPTQEACEKLIAARFAADVMGVSTIVLAR
HHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHEEEEEE
TDAEAANLVTSDHDANDRPFLTGERTQEGFYRVKNGLEQAISRGVAYAPYADLVWCETGV
CCCHHHHCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
PDIGFAREFAQAVHAACPGKLLSYNCSPSFNWKKNLNDQQIASFQDELSALGYKFQFITL
CCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHCCCCHHHHHHHHHHHHHHCCEEEEEEE
AGIHINWFNTFEFAHAYARGEGMKHYTDMVQEPEFAAREKGYSFVSHQQEVGAGYFDDVT
EEEEEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCHHHHHH
TVIQGGSSSVKALTGSTEEQQFH
HHHCCCCCCEEEECCCCHHCCCC
>Mature Secondary Structure 
PQSLNEQLSREQQIAALEKNWAQAPRWKGVKRGYGAADVVRLRGSLQPEHTLAQRGAEK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHCCCCHHHHHHHHHHHH
LWDKINGGAKKGYVNAFGAISAGQAMQQAKAGLEAVYLSGWQVAADGNTSETMYPDQSLY
HHHHHCCCCCCCCHHHHCCHHHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCCCCCCEE
AYDSVPAMVRRINNTFKRADEIQWGRGVNPGDKEFIDYFLPIVADAEAGFGGVLNAFELM
EHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
KNMISAGAAGVHFEDQLAAVKKCGHMGGKVLVPTQEACEKLIAARFAADVMGVSTIVLAR
HHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHEEEEEE
TDAEAANLVTSDHDANDRPFLTGERTQEGFYRVKNGLEQAISRGVAYAPYADLVWCETGV
CCCHHHHCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
PDIGFAREFAQAVHAACPGKLLSYNCSPSFNWKKNLNDQQIASFQDELSALGYKFQFITL
CCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHCCCCHHHHHHHHHHHHHHCCEEEEEEE
AGIHINWFNTFEFAHAYARGEGMKHYTDMVQEPEFAAREKGYSFVSHQQEVGAGYFDDVT
EEEEEEEEHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCHHHHHH
TVIQGGSSSVKALTGSTEEQQFH
HHHCCCCCCEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]