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The map label for this gene is engA

Identifier: 121637621

GI number: 121637621

Start: 1945505

End: 1946896

Strand: Direct

Name: engA

Synonym: BCG_1752

Alternate gene names: 121637621

Gene position: 1945505-1946896 (Clockwise)

Preceding gene: 121637620

Following gene: 121637622

Centisome position: 44.47

GC content: 68.82

Gene sequence:

>1392_bases
GTGACCCAGGACGGCACGTGGGTGGACGAAAGCGATTGGCAACTAGACGATTCGGAGATCGCGGAGTCCGGAGCGGCGCC
TGTGGTGGCGGTAGTCGGCCGGCCCAATGTCGGCAAGTCCACCCTGGTCAACCGGATCCTGGGCCGCCGCGAGGCGGTGG
TGCAGGATATTCCCGGCGTGACGCGTGACCGGGTCTGCTACGACGCGCTGTGGACCGGACGCCGGTTCGTCGTACAGGAC
ACCGGCGGATGGGAGCCCAATGCCAAGGGCCTGCAGCGGTTGGTGGCCGAGCAGGCCTCGGTGGCCATGCGCACCGCGGA
TGCGGTGATCCTGGTGGTCGACGCCGGTGTCGGTGCCACCGCCGCCGACGAGGCCGCGGCCCGTATCCTGTTGCGATCCG
GCAAGCCGGTGTTCTTGGCCGCCAACAAGGTCGACAGCGAAAAAGGCGAATCCGACGCCGCGGCGTTGTGGTCGCTGGGC
CTGGGTGAGCCGCATGCGATCAGCGCGATGCACGGTCGGGGGGTGGCCGACCTGCTCGACGGGGTGCTCGCCGCGCTGCC
CGAGGTGGGGGAGTCCGCGTCGGCGAGCGGCGGTCCTCGCCGGGTGGCGCTGGTCGGTAAGCCGAACGTCGGCAAGAGCT
CCCTGCTGAACAAACTCGCGGGTGATCAGCGATCGGTGGTCCATGAGGCGGCGGGCACCACCGTCGACCCGGTGGATTCG
CTGATCGAGTTGGGCGGTGACGTCTGGCGGTTCGTCGACACCGCGGGATTGCGGCGCAAGGTCGGCCAGGCCAGTGGGCA
TGAGTTCTACGCCTCGGTGCGCACGCACGCCGCCATCGACTCCGCCGAAGTGGCCATCGTCCTGATCGACGCGTCGCAGC
CGCTCACCGAACAGGACTTGCGAGTGATATCGATGGTCATCGAGGCCGGACGGGCGCTAGTCCTGGCCTACAACAAGTGG
GACCTGGTCGACGAGGACCGGCGCGAGCTGCTTCAGCGCGAGATCGACCGAGAGCTGGTGCAGGTGCGCTGGGCGCAACG
GGTCAACATCTCCGCCAAGACGGGCCGGGCGGTGCACAAGCTGGTGCCGGCCATGGAGGATGCGCTGGCGTCATGGGACA
CCAGGATCGCGACCGGCCCGCTGAACACCTGGCTCACAGAGGTGACGGCGGCCACACCGCCGCCGGTGCGCGGCGGCAAG
CAGCCACGCATCTTGTTCGCGACCCAGGCCACCGCGCGGCCACCGACGTTCGTGTTGTTCACCACGGGTTTTTTGGAGGC
CGGCTATCGGCGGTTCTTGGAGCGGCGGCTGCGTGAGACGTTCGGGTTTGACGGCAGCCCGATCCGGGTCAACGTGCGGG
TGCGAGAGAAGCGGGCCGGCAAGCGCCGCTGA

Upstream 100 bases:

>100_bases
CCGCCGGTGATGCCGTCATCGTGGACACCAGCGATATGACCGAGGCCGAGGTGGTCGCCCATCTGTTGGAGCTGGTCACG
CGGCGAAGTGAGGCAGTGCG

Downstream 100 bases:

>100_bases
GCGCACCTCGAACGTGTGACCCGGGTAACCGGGGATGGACAGCGAGGCCGGTTCTGCTGTCCCATAATGCGGCTATGTTC
AGCTGCATTACGGGATTTAG

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQD
TGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLG
LGEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDS
LIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKW
DLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGK
QPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR

Sequences:

>Translated_463_residues
MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQD
TGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLG
LGEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDS
LIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKW
DLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGK
QPRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR
>Mature_462_residues
TQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGVTRDRVCYDALWTGRRFVVQDT
GGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGATAADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGL
GEPHAISAMHGRGVADLLDGVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDSL
IELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDLRVISMVIEAGRALVLAYNKWD
LVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHKLVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQ
PRILFATQATARPPTFVLFTTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=466, Percent_Identity=35.4077253218884, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788919, Length=125, Percent_Identity=35.2, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507259, Length=125, Percent_Identity=35.2, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=207, Percent_Identity=27.0531400966184, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_MYCBO (P64058)

Other databases:

- EMBL:   BX248340
- RefSeq:   NP_855393.1
- ProteinModelPortal:   P64058
- SMR:   P64058
- EnsemblBacteria:   EBMYCT00000014984
- GeneID:   1092705
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1740
- GeneTree:   EBGT00050000016947
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK03003
- BioCyc:   MBOV233413:MB1740-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 49958; Mature: 49827

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGV
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
TRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGAT
CHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHEECCEEEEEEECCCCCC
AADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGEPHAISAMHGRGVADLLD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEHHHCCCCHHHHHH
GVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDS
HHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
LIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDL
HHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
RVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHK
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQPRILFATQATARPPTFVLF
HHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCEEEEE
TTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR
EHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
TQDGTWVDESDWQLDDSEIAESGAAPVVAVVGRPNVGKSTLVNRILGRREAVVQDIPGV
CCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
TRDRVCYDALWTGRRFVVQDTGGWEPNAKGLQRLVAEQASVAMRTADAVILVVDAGVGAT
CHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHEECCEEEEEEECCCCCC
AADEAAARILLRSGKPVFLAANKVDSEKGESDAAALWSLGLGEPHAISAMHGRGVADLLD
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEHHHCCCCHHHHHH
GVLAALPEVGESASASGGPRRVALVGKPNVGKSSLLNKLAGDQRSVVHEAAGTTVDPVDS
HHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHCCCCCHHHHH
LIELGGDVWRFVDTAGLRRKVGQASGHEFYASVRTHAAIDSAEVAIVLIDASQPLTEQDL
HHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
RVISMVIEAGRALVLAYNKWDLVDEDRRELLQREIDRELVQVRWAQRVNISAKTGRAVHK
HHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LVPAMEDALASWDTRIATGPLNTWLTEVTAATPPPVRGGKQPRILFATQATARPPTFVLF
HHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCEEEEE
TTGFLEAGYRRFLERRLRETFGFDGSPIRVNVRVREKRAGKRR
EHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972