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The map label for this gene is yciL [C]

Identifier: 121637619

GI number: 121637619

Start: 1944055

End: 1944819

Strand: Direct

Name: yciL [C]

Synonym: BCG_1750

Alternate gene names: 121637619

Gene position: 1944055-1944819 (Clockwise)

Preceding gene: 121637618

Following gene: 121637620

Centisome position: 44.44

GC content: 65.23

Gene sequence:

>765_bases
TTGATGGCCGAGCCGGAAGAGTCCCGGGAGCCCCGGGGCATCCGCCTGCAGAAAGTGTTGTCTCAGGCTGGAATCGCGTC
GAGGCGAGCCGCCGAGAAGATGATCGTCGACGGCCGCGTCGAAGTGGACGGGCACGTGGTGACCGAGTTGGGTACTCGGG
TCGACCCTCAGGTCGCGGTGGTCCGTGTCGACGGGGCCAGGGTGGTGCTCGACGACTCGCTGGTGTACTTGGCGCTGAAT
AAGCCGCGCGGCATGCACTCGACCATGTCCGACGATCGCGGCCGCCCGTGCATCGGCGACTTGATCGAACGAAAGGTCCG
GGGCACCAAGAAGCTTTTTCATGTCGGACGCCTAGACGCGGACACCGAGGGACTGATGCTGCTGACCAATGACGGCGAGT
TGGCGCACCGGTTGATGCATCCCTCCCATGAGGTGCCCAAGACGTATCTGGCGACGGTGACGGGGTCGGTGCCGCGTGGG
CTGGGCCGAACGCTGCGAGCGGGAATCGAATTGGACGACGGACCGGCGTTCGTCGACGATTTCGCGGTAGTGGATGCGAT
CCCCGGCAAGACGTTGGTGCGGGTAACGCTGCATGAGGGACGCAATCGCATTGTGCGCCGACTGCTGGCGGCCGCCGGCT
TCCCGGTGGAGGCATTGGTGCGTACCGATATCGGCGCGGTGTCACTGGGAAAGCAACGCCCGGGCAGCGTTCGGGCCTTG
CGGTCGAACGAGATCGGGCAACTGTACCAAGCGGTGGGCCTGTGA

Upstream 100 bases:

>100_bases
TTGACGACCTGAGCGAATCCCTGGACAGTGAGCCACGTTTCATCAAACTCACCGGTGAGCTGGCGTCCGAGCAGACGCTG
TCGTTCGACGTGGACCGTGA

Downstream 100 bases:

>100_bases
GTCGCCTAAGCGCAGCGGTAGTCGCGATCGACGGGCCGGCCGGCACCGGAAAATCCTCGGTGTCAAGGCGATTAGCGCGC
GAGCTGGGCGCACGCTTTCT

Product: hypothetical protein

Products: NA

Alternate protein names: RNA pseudouridylate synthase; RNA-uridine isomerase

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGHVVTELGTRVDPQVAVVRVDGARVVLDDSLVYLALN
KPRGMHSTMSDDRGRPCIGDLIERKVRGTKKLFHVGRLDADTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRG
LGRTLRAGIELDDGPAFVDDFAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRTDIGAVSLGKQRPGSVRAL
RSNEIGQLYQAVGL

Sequences:

>Translated_254_residues
MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGHVVTELGTRVDPQVAVVRVDGARVVLDDSLVYLALN
KPRGMHSTMSDDRGRPCIGDLIERKVRGTKKLFHVGRLDADTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRG
LGRTLRAGIELDDGPAFVDDFAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRTDIGAVSLGKQRPGSVRAL
RSNEIGQLYQAVGL
>Mature_254_residues
MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGHVVTELGTRVDPQVAVVRVDGARVVLDDSLVYLALN
KPRGMHSTMSDDRGRPCIGDLIERKVRGTKKLFHVGRLDADTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRG
LGRTLRAGIELDDGPAFVDDFAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRTDIGAVSLGKQRPGSVRAL
RSNEIGQLYQAVGL

Specific function: Unknown

COG id: COG1187

COG function: function code J; 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787524, Length=225, Percent_Identity=42.6666666666667, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790453, Length=241, Percent_Identity=34.0248962655602, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1788510, Length=236, Percent_Identity=34.3220338983051, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87081838, Length=178, Percent_Identity=34.2696629213483, Blast_Score=92, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1711_MYCTU (P65842)

Other databases:

- EMBL:   BX842577
- EMBL:   AE000516
- PIR:   F70504
- RefSeq:   NP_216227.1
- RefSeq:   NP_336208.1
- ProteinModelPortal:   P65842
- SMR:   P65842
- EnsemblBacteria:   EBMYCT00000000216
- EnsemblBacteria:   EBMYCT00000070097
- GeneID:   885122
- GeneID:   923953
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1751.1
- KEGG:   mtu:Rv1711
- TIGR:   MT1751.1
- TubercuList:   Rv1711
- GeneTree:   EBGT00050000016309
- HOGENOM:   HBG754478
- OMA:   DDLGRPC
- ProtClustDB:   CLSK791343
- GO:   GO:0040007
- InterPro:   IPR020103
- InterPro:   IPR006145
- InterPro:   IPR000748
- InterPro:   IPR018496
- InterPro:   IPR002942
- SMART:   SM00363
- TIGRFAMs:   TIGR00093

Pfam domain/function: PF00849 PseudoU_synth_2; PF01479 S4; SSF55120 PsdUridine_synth_cat_dom

EC number: NA

Molecular weight: Translated: 27597; Mature: 27597

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS01149 PSI_RSU; PS50889 S4

Important sites: ACT_SITE 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGHVVTELGTRVDPQVAV
CCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHEECCEEEECCEEEEHHCCCCCCCEEE
VRVDGARVVLDDSLVYLALNKPRGMHSTMSDDRGRPCIGDLIERKVRGTKKLFHVGRLDA
EEECCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRGLGRTLRAGIELDDGPAFVDD
CCCCEEEEECCHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCEECCCCCHHHH
FAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRTDIGAVSLGKQRPGSVRAL
HHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEECCCCCCCCEEEE
RSNEIGQLYQAVGL
CCCHHHHHHHHHCC
>Mature Secondary Structure
MMAEPEESREPRGIRLQKVLSQAGIASRRAAEKMIVDGRVEVDGHVVTELGTRVDPQVAV
CCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHEECCEEEECCEEEEHHCCCCCCCEEE
VRVDGARVVLDDSLVYLALNKPRGMHSTMSDDRGRPCIGDLIERKVRGTKKLFHVGRLDA
EEECCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DTEGLMLLTNDGELAHRLMHPSHEVPKTYLATVTGSVPRGLGRTLRAGIELDDGPAFVDD
CCCCEEEEECCHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHCCCEECCCCCHHHH
FAVVDAIPGKTLVRVTLHEGRNRIVRRLLAAAGFPVEALVRTDIGAVSLGKQRPGSVRAL
HHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEECCCCCCCCEEEE
RSNEIGQLYQAVGL
CCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036