Click here to switch to the map view.

The map label for this gene is argC

Identifier: 121637560

GI number: 121637560

Start: 1870843

End: 1871901

Strand: Direct

Name: argC

Synonym: BCG_1691

Alternate gene names: 121637560

Gene position: 1870843-1871901 (Clockwise)

Preceding gene: 121637558

Following gene: 121637561

Centisome position: 42.77

GC content: 69.69

Gene sequence:

>1059_bases
ATGCAAAATCGGCAGGTGGCCAATGCGACGAAGGTGGCGGTTGCCGGTGCCAGCGGATATGCCGGTGGTGAGATTCTCCG
CCTGCTGCTCGGGCATCCGGCGTACGCCGACGGCCGGCTGAGGATCGGTGCGCTGACCGCGGCGACCAGCGCCGGCAGCA
CGCTCGGCGAACACCATCCGCACCTGACGCCGCTGGCCCATCGAGTAGTCGAACCCACCGAAGCTGCCGTGCTCGGTGGC
CATGACGCCGTCTTCTTGGCCTTGCCGCACGGGCATTCGGCGGTGTTGGCGCAGCAACTGAGCCCCGAGACACTGATCAT
CGACTGCGGGGCGGACTTTCGGCTCACCGACGCCGCCGTCTGGGAGCGGTTCTACGGGTCGTCGCACGCCGGTAGCTGGC
CGTATGGGTTGCCCGAGCTGCCGGGCGCGCGGGACCAATTGCGCGGCACCCGCCGCATCGCGGTGCCCGGCTGCTATCCG
ACCGCGGCACTGCTGGCGCTTTTTCCCGCGCTGGCCGCAGACCTTATCGAGCCCGCGGTGACCGTGGTCGCCGTGAGCGG
TACCTCGGGGGCGGGTCGTGCGGCCACCACCGACTTGCTGGGCGCGGAGGTCATCGGGTCGGCGCGCGCCTACAACATCG
CCGGCGTCCACCGGCACACCCCCGAGATCGCTCAAGGGCTACGCGCGGTCACCGACCGCGACGTCTCGGTCTCGTTTACC
CCGGTGCTGATCCCGGCCTCCCGTGGCATCCTGGCCACCTGCACGGCACGCACCCGATCACCCCTGTCGCAGCTGCGGGC
AGCCTACGAAAAGGCCTACCATGCAGAGCCTTTCATTTATCTGATGCCGGAGGGGCAGCTGCCGCGCACCGGCGCGGTGA
TCGGCAGCAACGCAGCGCACATCGCCGTCGCGGTGGACGAGGACGCGCAGACGTTCGTGGCGATCGCCGCGATCGACAAC
CTGGTCAAGGGCACCGCCGGCGCCGCGGTGCAATCGATGAACCTGGCGCTGGGCTGGCCGGAGACCGACGGCCTTTCGGT
TGTGGGGGTGGCGCCGTGA

Upstream 100 bases:

>100_bases
TTTTCGCGGACGCAACTTCGAGTCCCATCGGCGCCGCCCGGCGGTGTGTCAAGTCCCGGCGCAGTCACCGCGGAATGAGT
TTGCAAACTGTTGCATAACG

Downstream 100 bases:

>100_bases
CCGACCTGGCCGGCACCACCCGGCTGCTGCGCGCTCAGGGCGTCACCGCCCCGGCCGGCTTTCGGGCCGCCGGCGTCGCC
GCCGGGATCAAGGCCTCCGG

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGG
HDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYP
TAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFT
PVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDN
LVKGTAGAAVQSMNLALGWPETDGLSVVGVAP

Sequences:

>Translated_352_residues
MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGG
HDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYP
TAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFT
PVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDN
LVKGTAGAAVQSMNLALGWPETDGLSVVGVAP
>Mature_352_residues
MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHPHLTPLAHRVVEPTEAAVLGG
HDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAVWERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYP
TAALLALFPALAADLIEPAVTVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFT
PVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAHIAVAVDEDAQTFVAIAAIDN
LVKGTAGAAVQSMNLALGWPETDGLSVVGVAP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=351, Percent_Identity=36.7521367521368, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320913, Length=370, Percent_Identity=25.4054054054054, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_MYCBO (P63563)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855332.1
- ProteinModelPortal:   P63563
- SMR:   P63563
- EnsemblBacteria:   EBMYCT00000015211
- GeneID:   1092622
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1680
- GeneTree:   EBGT00050000015828
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- ProtClustDB:   PRK00436
- BioCyc:   MBOV233413:MB1680-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 36305; Mature: 36305

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 158-158

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHP
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHCCCC
HLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAV
CCCHHHHHHCCCCHHEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEECCCCCEEHHHHH
WERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAALLALFPALAADLIEPAV
HHHHCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCE
TVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFT
EEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEE
PVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAH
EEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCCCEE
IAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWPETDGLSVVGVAP
EEEEECCCCCCEEHHHHHHHHHHCCCCHHEEECEEEECCCCCCCEEEEEECC
>Mature Secondary Structure
MQNRQVANATKVAVAGASGYAGGEILRLLLGHPAYADGRLRIGALTAATSAGSTLGEHHP
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHCCCC
HLTPLAHRVVEPTEAAVLGGHDAVFLALPHGHSAVLAQQLSPETLIIDCGADFRLTDAAV
CCCHHHHHHCCCCHHEEECCCCEEEEEECCCCHHHHHHHCCCCEEEEECCCCCEEHHHHH
WERFYGSSHAGSWPYGLPELPGARDQLRGTRRIAVPGCYPTAALLALFPALAADLIEPAV
HHHHCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCE
TVVAVSGTSGAGRAATTDLLGAEVIGSARAYNIAGVHRHTPEIAQGLRAVTDRDVSVSFT
EEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEE
PVLIPASRGILATCTARTRSPLSQLRAAYEKAYHAEPFIYLMPEGQLPRTGAVIGSNAAH
EEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEECCCCEE
IAVAVDEDAQTFVAIAAIDNLVKGTAGAAVQSMNLALGWPETDGLSVVGVAP
EEEEECCCCCCEEHHHHHHHHHHCCCCHHEEECEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972