Click here to switch to the map view.

The map label for this gene is impA [H]

Identifier: 121637511

GI number: 121637511

Start: 1809286

End: 1810098

Strand: Direct

Name: impA [H]

Synonym: BCG_1642

Alternate gene names: 121637511

Gene position: 1809286-1810098 (Clockwise)

Preceding gene: 121637510

Following gene: 121637512

Centisome position: 41.36

GC content: 64.82

Gene sequence:

>813_bases
ATGCACTTGGATTCGTTGGTTGCCCCGCTGGTTGAACAGGCGTCGGCGATCCTGGATGCCGCAACGGCGCTCTTTCTCGT
CGGTCATCGCGCCGATTCAGCGGTCCGCAAGAAGGGTAACGACTTCGCCACCGAAGTCGATCTAGCGATCGAGCGGCAGG
TTGTCGCAGCGCTGGTGGCGGCCACCGGCATCGAGGTGCACGGCGAGGAATTCGGCGGCCCGGCAGTCGACTCGCGGTGG
GTGTGGGTACTGGACCCCATCGACGGCACAATCAACCACGCCGCCGGATCGCCGTTGGCTGCGATCCTGTTGGGCCTGCT
GCACGACGGAGTTCCGGTGGCCGGCTTGACCTGGATGCCATTCACCGACCAACGCTATACCGCCGTGGCGGGTGGTCCGC
TGATCAAGAACGGTGTACCGCAGCCGCCGCTGGCTGACGCCGAACTGGCCAACGTGCTCGTCGGCGTCGGCACATTCAGC
GCCGACTCACGGGGCCAGTTCCCGGGGCGATATCGACTGGCGGTGCTGGAAAAGCTCAGCCGAGTGTCATCGCGGCTGCG
CATGCACGGATCCACCGGCATCGATCTCGTCTTCGTCGCTGACGGGATACTCGGTGGTGCAATAAGTTTCGGAGGTCACG
TTTGGGACCATGCCGCTGGGGTGGCGTTGGTACGAGCCGCCGGTGGCGTGGTCACCGACCTGGCTGGGCAACCGTGGACC
CCTGCATCGCGTTCTGCCTTGGCCGGGCCACTGCGCGTGCATGCCCAGATCCTCGAGATTCTTGGCAGCATAGGGGAACC
AGAGGACTACTGA

Upstream 100 bases:

>100_bases
ACGCACCGCGGCGTCGAGGGGGCCATCGTCGGCAAGGCCCTCTACGCCCGTCGGTTCACCTTGCCGCAAGCGTTGGCCGC
GGTTCGGGACTAGATCGGCG

Downstream 100 bases:

>100_bases
GATGTATGCCGACCGTGACCTTCCGGGGGCTGGGGGCCTCGCGGTACGCGTGATCCCGTGTCTGGATGTCGACGATGGGC
GGGTGGTCAAGGGAGTCAAC

Product: putative inositol-monophosphatase impA

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRW
VWVLDPIDGTINHAAGSPLAAILLGLLHDGVPVAGLTWMPFTDQRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFS
ADSRGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWT
PASRSALAGPLRVHAQILEILGSIGEPEDY

Sequences:

>Translated_270_residues
MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRW
VWVLDPIDGTINHAAGSPLAAILLGLLHDGVPVAGLTWMPFTDQRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFS
ADSRGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWT
PASRSALAGPLRVHAQILEILGSIGEPEDY
>Mature_270_residues
MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVAATGIEVHGEEFGGPAVDSRW
VWVLDPIDGTINHAAGSPLAAILLGLLHDGVPVAGLTWMPFTDQRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFS
ADSRGQFPGRYRLAVLEKLSRVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWT
PASRSALAGPLRVHAQILEILGSIGEPEDY

Specific function: Catalyzes the dephosphorylation of inositol-1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=176, Percent_Identity=28.4090909090909, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI221625487, Length=176, Percent_Identity=28.4090909090909, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788882, Length=231, Percent_Identity=29.8701298701299, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193202570, Length=259, Percent_Identity=31.6602316602317, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193202572, Length=258, Percent_Identity=30.6201550387597, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320493, Length=207, Percent_Identity=28.5024154589372, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357329, Length=256, Percent_Identity=30.078125, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357303, Length=238, Percent_Identity=28.1512605042017, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.25 [H]

Molecular weight: Translated: 28000; Mature: 28000

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINHAAGSPLAAILLGLLHDGVPVAGLTWMP
HHCCEECCHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECC
FTDQRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADSRGQFPGRYRLAVLEKLS
CCCCCEEEEECCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
RVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWT
HHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCCC
PASRSALAGPLRVHAQILEILGSIGEPEDY
CCCHHHHCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINHAAGSPLAAILLGLLHDGVPVAGLTWMP
HHCCEECCHHCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEECC
FTDQRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADSRGQFPGRYRLAVLEKLS
CCCCCEEEEECCCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
RVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWT
HHHHHHHHCCCCCEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCCCC
PASRSALAGPLRVHAQILEILGSIGEPEDY
CCCHHHHCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]