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The map label for this gene is hisA

Identifier: 121637510

GI number: 121637510

Start: 1808541

End: 1809278

Strand: Direct

Name: hisA

Synonym: BCG_1641

Alternate gene names: 121637510

Gene position: 1808541-1809278 (Clockwise)

Preceding gene: 121637509

Following gene: 121637511

Centisome position: 41.34

GC content: 66.67

Gene sequence:

>738_bases
GTGATGCCGCTGATACTTTTGCCCGCCGTCGACGTGGTCGAGGGTCGTGCCGTGCGCCTCGTTCAAGGGAAGGCCGGCAG
CCAAACCGAGTACGGCTCAGCGGTGGATGCCGCGTTGGGCTGGCAACGCGATGGCGCCGAGTGGATCCATTTGGTGGACC
TGGATGCTGCGTTCGGCCGCGGTTCCAACCACGAACTGCTTGCCGAGGTTGTCGGCAAGCTCGACGTACAGGTTGAGCTA
TCCGGCGGTATTCGAGACGACGAGTCGCTGGCCGCGGCGCTGGCCACCGGATGCGCTCGGGTCAATGTGGGCACTGCTGC
CCTGGAAAACCCGCAGTGGTGTGCCCGGGTGATTGGCGAGCACGGCGACCAGGTCGCCGTCGGCTTGGACGTCCAGATCA
TCGACGGCGAGCATCGGTTGCGCGGACGCGGCTGGGAAACCGACGGCGGCGACCTGTGGGACGTGCTAGAACGCCTAGAC
AGTGAAGGATGTTCGCGGTTCGTCGTGACCGATATCACCAAGGACGGCACCCTGGGCGGCCCCAATCTGGACCTGCTGGC
CGGTGTTGCCGACCGCACCGACGCCCCGGTGATCGCGTCCGGAGGTGTGTCCAGCCTCGATGACCTGCGCGCCATTGCGA
CTCTCACGCACCGCGGCGTCGAGGGGGCCATCGTCGGCAAGGCCCTCTACGCCCGTCGGTTCACCTTGCCGCAAGCGTTG
GCCGCGGTTCGGGACTAG

Upstream 100 bases:

>100_bases
GGACGGCGCATTGGCCGCCACCCAGTTTCATCCGGAGAAGAGTGGCGATGCCGGTGCAGCCGTACTGAGCAACTGGGTTG
ATGGACTTTAAAGGATACTG

Downstream 100 bases:

>100_bases
ATCGGCGATGCACTTGGATTCGTTGGTTGCCCCGCTGGTTGAACAGGCGTCGGCGATCCTGGATGCCGCAACGGCGCTCT
TTCTCGTCGGTCATCGCGCC

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVEL
SGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLD
SEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL
AAVRD

Sequences:

>Translated_245_residues
MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVEL
SGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLD
SEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL
AAVRD
>Mature_245_residues
MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGRGSNHELLAEVVGKLDVQVEL
SGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLD
SEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL
AAVRD

Specific function: Involved in both the histidine and tryptophan biosynthetic pathways

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=35.1020408163265, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788336, Length=246, Percent_Identity=24.390243902439, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_MYCBP (A1KJ19)

Other databases:

- EMBL:   AM408590
- RefSeq:   YP_977733.1
- ProteinModelPortal:   A1KJ19
- SMR:   A1KJ19
- STRING:   A1KJ19
- EnsemblBacteria:   EBMYCT00000021912
- GeneID:   4696068
- GenomeReviews:   AM408590_GR
- KEGG:   mbb:BCG_1641
- eggNOG:   COG0106
- GeneTree:   EBGT00050000015857
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- ProtClustDB:   PRK14024
- BioCyc:   MBOV410289:BCG_1641-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01919

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16; =5.3.1.24

Molecular weight: Translated: 25763; Mature: 25763

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: ACT_SITE 11-11 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGR
CCCEEEECCCHHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEECHHHCC
GSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGE
CCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEECCHHHCCCHHHHHHHHHC
HGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGG
CCCEEEEEEEEEEECCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
PNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL
CCHHHEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
AAVRD
HHHCC
>Mature Secondary Structure
MMPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHLVDLDAAFGR
CCCEEEECCCHHHCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCEEEEEEECHHHCC
GSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARVNVGTAALENPQWCARVIGE
CCCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEECCHHHCCCHHHHHHHHHC
HGDQVAVGLDVQIIDGEHRLRGRGWETDGGDLWDVLERLDSEGCSRFVVTDITKDGTLGG
CCCEEEEEEEEEEECCCHHCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCC
PNLDLLAGVADRTDAPVIASGGVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQAL
CCHHHEECCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
AAVRD
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA