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The map label for this gene is hisC1

Identifier: 121637507

GI number: 121637507

Start: 1806143

End: 1807285

Strand: Direct

Name: hisC1

Synonym: BCG_1638

Alternate gene names: 121637507

Gene position: 1806143-1807285 (Clockwise)

Preceding gene: 121637506

Following gene: 121637508

Centisome position: 41.29

GC content: 63.08

Gene sequence:

>1143_bases
ATGACCAGGTCCGGACACCCGGTTACATTGGACGACTTGCCGCTGCGCGCCGACTTGCGTGGTAAAGCACCATACGGTGC
ACCGCAATTAGCTGTTCCGGTACGGCTGAACACCAACGAGAACCCGCACCCGCCTACCCGGGCGCTGGTTGACGACGTGG
TGCGATCGGTGCGGGAAGCGGCCATCGACTTGCACCGCTACCCCGACCGCGACGCCGTGGCTCTGCGTGCTGACTTGGCC
GGCTATCTCACCGCGCAGACCGGAATCCAGCTTGGTGTCGAAAACATATGGGCTGCCAACGGTTCCAATGAGATTCTGCA
GCAACTGTTACAGGCGTTTGGCGGTCCGGGGCGTAGCGCGATCGGTTTCGTACCGTCCTATTCGATGCACCCGATCATCT
CCGACGGCACCCACACGGAATGGATCGAGGCGTCCCGCGCCAATGACTTCGGTCTCGACGTGGACGTCGCCGTCGCGGCT
GTGGTCGATCGCAAACCCGATGTGGTGTTCATTGCTAGCCCTAACAACCCGTCCGGACAAAGTGTTTCGTTACCTGACCT
GTGTAAGCTGCTGGACGTTGCGCCCGGAATTGCGATCGTCGACGAGGCCTACGGCGAGTTCTCCTCGCAGCCCAGCGCGG
TGTCGCTGGTCGAGGAGTATCCGAGCAAGCTCGTCGTCACGCGCACCATGAGCAAGGCATTCGCTTTCGCCGGCGGCAGG
CTCGGATACCTGATCGCTACGCCCGCGGTGATCGACGCAATGCTGCTGGTGCGGTTGCCGTATCACCTGTCGTCGGTCAC
TCAAGCCGCGGCCCGGGCCGCGCTGCGGCACTCCGACGACACCTTGAGCAGTGTCGCCGCACTGATCGCCGAACGCGAAC
GCGTAACAACCTCATTGAACGACATGGGTTTTCGAGTCATCCCAAGCGATGCCAACTTCGTGTTGTTCGGCGAGTTTGCC
GATGCGCCGGCCGCCTGGCGGCGCTATCTGGAGGCCGGCATTTTGATCCGCGACGTTGGGATTCCCGGCTATCTGCGGGC
CACCACCGGGCTGGCTGAGGAGAACGATGCGTTCCTGCGGGCAAGCGCCCGGATCGCCACCGACCTGGTCCCCGTCACCC
GCAGTCCTGTAGGAGCGCCATGA

Upstream 100 bases:

>100_bases
CGGAGGCGGCCCTCAAAGACGTTTCCGGACACGTGATCACGCTCGCCACGGCCGAGGACTTGCCGGCGCACGGTGAGGCG
GTACGGCGGAGGTTCGAGCG

Downstream 100 bases:

>100_bases
CAACCACCCAGACAGCCAAAGCTAGCCGGCGGGCGCGTATCGAACGGCGTACCCGCGAATCCGATATCGTCATCGAGCTC
GACCTTGACGGTACCGGGCA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREAAIDLHRYPDRDAVALRADLA
GYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAA
VVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGR
LGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLNDMGFRVIPSDANFVLFGEFA
DAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAFLRASARIATDLVPVTRSPVGAP

Sequences:

>Translated_380_residues
MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREAAIDLHRYPDRDAVALRADLA
GYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAA
VVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGR
LGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLNDMGFRVIPSDANFVLFGEFA
DAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAFLRASARIATDLVPVTRSPVGAP
>Mature_379_residues
TRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREAAIDLHRYPDRDAVALRADLAG
YLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAAV
VDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGRL
GYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLNDMGFRVIPSDANFVLFGEFAD
APAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAFLRASARIATDLVPVTRSPVGAP

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=374, Percent_Identity=32.3529411764706, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322075, Length=355, Percent_Identity=27.0422535211268, Blast_Score=113, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_MYCBO (P0A679)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855279.1
- ProteinModelPortal:   P0A679
- SMR:   P0A679
- EnsemblBacteria:   EBMYCT00000016820
- GeneID:   1092516
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1626
- GeneTree:   EBGT00070000031717
- HOGENOM:   HBG646350
- OMA:   GRTAIGF
- ProtClustDB:   PRK03317
- BioCyc:   MBOV233413:MB1626-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40581; Mature: 40450

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREA
CCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
AIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSA
HHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHEECCCCHHHHHHHHHHHCCCCCCC
IGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAAVVDRKPDVVFIASPNNPSGQ
EECCCCCCCCCEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC
SVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGR
CCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHCCCC
LGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLN
EEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DMGFRVIPSDANFVLFGEFADAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAFLR
HCCCEEECCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCCCCEEHHHCCCCCCCCHHHH
ASARIATDLVPVTRSPVGAP
HHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREA
CCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
AIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSA
HHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHEECCCCHHHHHHHHHHHCCCCCCC
IGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAAVVDRKPDVVFIASPNNPSGQ
EECCCCCCCCCEECCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCC
SVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGR
CCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHCCCC
LGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLN
EEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DMGFRVIPSDANFVLFGEFADAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAFLR
HCCCEEECCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCCCCEEHHHCCCCCCCCHHHH
ASARIATDLVPVTRSPVGAP
HHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972