Click here to switch to the map view.

The map label for this gene is hisB

Identifier: 121637508

GI number: 121637508

Start: 1807282

End: 1807914

Strand: Direct

Name: hisB

Synonym: BCG_1639

Alternate gene names: 121637508

Gene position: 1807282-1807914 (Clockwise)

Preceding gene: 121637507

Following gene: 121637509

Centisome position: 41.31

GC content: 63.82

Gene sequence:

>633_bases
ATGACAACCACCCAGACAGCCAAAGCTAGCCGGCGGGCGCGTATCGAACGGCGTACCCGCGAATCCGATATCGTCATCGA
GCTCGACCTTGACGGTACCGGGCAGGTGGCCGTCGACACCGGTGTTCCGTTCTACGACCACATGTTGACCGCGCTGGGCA
GTCACGCCAGCTTCGACCTCACCGTGCGCGCCACAGGTGATGTCGAAATCGAAGCCCATCACACCATCGAGGACACGGCA
ATCGCGCTGGGCACCGCGCTCGGGCAGGCCCTAGGTGACAAGAGGGGCATCCGCCGGTTTGGCGATGCCTTCATCCCGAT
GGACGAAACACTGGCCCACGCCGCCGTCGACTTATCCGGCCGCCCCTATTGCGTGCATACCGGAGAGCCGGATCACCTGC
AGCACACCACTATTGCCGGCAGTTCAGTGCCCTACCACACCGTCATCAACCGGCACGTGTTCGAATCGTTGGCGGCCAAC
GCCCGCATCGCGCTGCACGTCCGCGTGTTGTACGGGCGCGACCCGCACCATATCACCGAAGCTCAATACAAGGCCGTCGC
GCGCGCGTTGCGTCAAGCGGTCGAGCCAGATCCTCGGGTGTCAGGCGTGCCGTCCACCAAAGGTGCTCTGTGA

Upstream 100 bases:

>100_bases
CCACCACCGGGCTGGCTGAGGAGAACGATGCGTTCCTGCGGGCAAGCGCCCGGATCGCCACCGACCTGGTCCCCGTCACC
CGCAGTCCTGTAGGAGCGCC

Downstream 100 bases:

>100_bases
CAGCAAAATCGGTTGTAGTCCTTGACTACGGCTCAGGAAACCTGCGGTCGGCCCAACGTGCGCTGCAACGAGTAGGCGCC
GAGGTCGAAGTAACCGCCGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTA
IALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAAN
ARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL

Sequences:

>Translated_210_residues
MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTA
IALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAAN
ARIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL
>Mature_209_residues
TTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDLTVRATGDVEIEAHHTIEDTAI
ALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSGRPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANA
RIALHVRVLYGRDPHHITEAQYKAVARALRQAVEPDPRVSGVPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=212, Percent_Identity=40.5660377358491, Blast_Score=150, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324776, Length=224, Percent_Identity=37.5, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_MYCBO (P64369)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855280.1
- ProteinModelPortal:   P64369
- SMR:   P64369
- EnsemblBacteria:   EBMYCT00000015685
- GeneID:   1092519
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1627
- GeneTree:   EBGT00050000017533
- HOGENOM:   HBG289010
- OMA:   RQAVEYD
- ProtClustDB:   PRK00951
- BioCyc:   MBOV233413:MB1627-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22770; Mature: 22639

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDL
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCCEEE
TVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSG
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCC
RPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITE
CCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHH
AQYKAVARALRQAVEPDPRVSGVPSTKGAL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTTQTAKASRRARIERRTRESDIVIELDLDGTGQVAVDTGVPFYDHMLTALGSHASFDL
CCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCCEEE
TVRATGDVEIEAHHTIEDTAIALGTALGQALGDKRGIRRFGDAFIPMDETLAHAAVDLSG
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCC
RPYCVHTGEPDHLQHTTIAGSSVPYHTVINRHVFESLAANARIALHVRVLYGRDPHHITE
CCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHH
AQYKAVARALRQAVEPDPRVSGVPSTKGAL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972