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The map label for this gene is hisD

Identifier: 121637506

GI number: 121637506

Start: 1804830

End: 1806146

Strand: Direct

Name: hisD

Synonym: BCG_1637

Alternate gene names: 121637506

Gene position: 1804830-1806146 (Clockwise)

Preceding gene: 121637504

Following gene: 121637507

Centisome position: 41.26

GC content: 69.63

Gene sequence:

>1317_bases
GTGCTTACCCGTATCGACTTGCGGGGAGCCGAGTTGACAGCTGCCGAGCTGCGGGCCGCTCTGCCACGCGGCGGCGCCGA
TGTGGAAGCCGTGCTGCCGACGGTACGGCCCATTGTGGCGGCCGTCGCCGAGCGCGGGGCCGAGGCCGCGCTGGACTTCG
GCGCATCGTTCGACGGTGTGCGGCCCCATGCCATCCGGGTGCCAGACGCAGCGCTGGACGCGGCGCTGGCCGGACTGGAC
TGCGACGTCTGCGAAGCGTTGCAGGTGATGGTCGAGCGGACCCGCGCCGTGCACTCCGGGCAGCGTCGCACCGACGTCAC
AACCACACTGGGCCCGGGCGCGACGGTCACCGAGCGGTGGGTTCCGGTCGAGCGGGTAGGCCTGTACGTGCCGGGGGGCA
ATGCGGTGTACCCATCCAGCGTGGTGATGAACGTGGTGCCCGCCCAAGCCGCGGGCGTCGACTCGTTGGTGGTAGCCAGC
CCGCCGCAGGCGCAGTGGGATGGAATGCCGCATCCGACCATTCTGGCCGCGGCCCGGCTGCTGGGCGTCGATGAGGTCTG
GGCGGTCGGCGGCGCTCAGGCGGTGGCGTTGCTGGCTTACGGCGGCACCGACACCGACGGCGCAGCACTGACACCGGTCG
ACATGATCACCGGGCCTGGCAACATCTATGTCACGGCCGCCAAGCGACTGTGCCGTTCGCGGGTGGGCATCGACGCCGAA
GCGGGGCCAACCGAGATCGCTATCCTCGCCGATCACACCGCCGACCCGGTGCATGTGGCCGCCGACCTGATTAGCCAGGC
CGAACACGACGAGTTGGCTGCCAGCGTGCTGGTCACTCCGAGTGAGGACCTGGCCGATGCCACCGACGCCGAACTGGCTG
GCCAGCTGCAGACTACGGTGCACCGCGAACGGGTGACGGCCGCGCTGACCGGACGCCAATCGGCGATCGTCCTGGTCGAC
GACGTGGACGCCGCCGTCTTGGTGGTGAACGCTTACGCCGCTGAGCATTTGGAGATTCAGACCGCCGATGCCCCGCAGGT
TGCCAGCCGGATCCGCTCGGCGGGAGCCATTTTCGTCGGCCCGTGGTCCCCGGTGAGCCTCGGCGACTACTGCGCGGGAT
CCAACCATGTACTGCCGACCGCGGGCTGCGCCCGGCATTCCAGCGGCCTGTCGGTGCAGACGTTCCTGCGCGGCATCCAC
GTCGTGGAATACACGGAGGCGGCCCTCAAAGACGTTTCCGGACACGTGATCACGCTCGCCACGGCCGAGGACTTGCCGGC
GCACGGTGAGGCGGTACGGCGGAGGTTCGAGCGATGA

Upstream 100 bases:

>100_bases
TGGCGGCTCCTCTTTGCCGGTCCTTTCTACTGCACTGTACCGGTCAGATATCGACTTGAGCTGCTCTGGGAGAATGGTCT
ACGTGACCGCGCCGCCGCCC

Downstream 100 bases:

>100_bases
CCAGGTCCGGACACCCGGTTACATTGGACGACTTGCCGCTGCGCGCCGACTTGCGTGGTAAAGCACCATACGGTGCACCG
CAATTAGCTGTTCCGGTACG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLD
CDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVAS
PPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAE
AGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVD
DVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIH
VVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER

Sequences:

>Translated_438_residues
MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLD
CDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVAS
PPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAE
AGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVD
DVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIH
VVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER
>Mature_438_residues
MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLD
CDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVAS
PPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAE
AGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVD
DVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIH
VVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=37.8048780487805, Blast_Score=238, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=35.796766743649, Blast_Score=234, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_MYCBO (P63951)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855278.1
- ProteinModelPortal:   P63951
- SMR:   P63951
- EnsemblBacteria:   EBMYCT00000016947
- GeneID:   1092514
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1625
- GeneTree:   EBGT00050000017368
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- ProtClustDB:   PRK00877
- BioCyc:   MBOV233413:MB1625-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 45379; Mature: 45379

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 335-335 ACT_SITE 336-336 BINDING 129-129 BINDING 193-193 BINDING 221-221 BINDING 244-244 BINDING 266-266 BINDING 269-269 BINDING 336-336 BINDING 369-369 BINDING 423-423 BINDING 428-428

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGV
CCEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
RPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERW
CCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHCC
VPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQWDGMPHPTILAAARL
CCHHHEEEEECCCCCCCCCHHHHEECCCHHCCCCEEEEECCCCHHCCCCCCHHHHHHHHH
LGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAE
HCCHHHHHCCCCCEEEEEEECCCCCCCCEECCHHEEECCCCEEEHHHHHHHHHHCCCCCC
AGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTV
CCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEECCCHHHCCCCCHHHHHHHHHHH
HRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVG
HHHHHHHHCCCCCEEEEEEECCCEEEEEEEHHHHCCEEEECCCCHHHHHHHHHCCEEEEC
PWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHVITLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
TAEDLPAHGEAVRRRFER
ECCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGV
CCEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCC
RPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERW
CCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHCC
VPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQWDGMPHPTILAAARL
CCHHHEEEEECCCCCCCCCHHHHEECCCHHCCCCEEEEECCCCHHCCCCCCHHHHHHHHH
LGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAE
HCCHHHHHCCCCCEEEEEEECCCCCCCCEECCHHEEECCCCEEEHHHHHHHHHHCCCCCC
AGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTV
CCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEECCCHHHCCCCCHHHHHHHHHHH
HRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVG
HHHHHHHHCCCCCEEEEEEECCCEEEEEEEHHHHCCEEEECCCCHHHHHHHHHCCEEEEC
PWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHVITLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
TAEDLPAHGEAVRRRFER
ECCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972