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The map label for this gene is echA9 [H]

Identifier: 121637000

GI number: 121637000

Start: 1226354

End: 1227391

Strand: Reverse

Name: echA9 [H]

Synonym: BCG_1129c

Alternate gene names: 121637000

Gene position: 1227391-1226354 (Counterclockwise)

Preceding gene: 121637003

Following gene: 121636999

Centisome position: 28.06

GC content: 65.51

Gene sequence:

>1038_bases
GTGACCGGCGAATCGCATGAGGTCCTGACAAACGTCGAGGGCGGTGTCGGATTCGTGACGCTCAACCGCCCCAAGGCGAT
CAACTCACTGAACCAAACCATGGTCGACCTGCTGGCCACAGTGCTCATGAGCTGGGAGCATGAGGACGCGGTGCACGCGG
TGGTGCTCTCCGGAGCCGGCGAACGCGGACTTTGCGCCGGCGGGGACGTGGTGGCCGTCTACCACAGTGCCCGCAAGGAC
GGGGTCGAGGCGCGGCGGTTCTGGCGCCACGAGTATCTGCTCAACGCCCTGATCGGCCGGTTCGCCAAGCCCTACGTGGC
GTTGATGGACGGCATCGTAATGGGCGGCGGCGTCGGCGTCAGCGCACACGCGAACACCCGGGTGGTTACCGATACCTCCA
AGGTCGCGATGCCCGAAGTGGGCATCGGGTTCATCCCCGACGTCGGCGGGGTGTATTTGCTGTCGCGTGCACCCGGCGCG
CTGGGTCTGCACGCCGCCCTGACTGGAGCGCCGTTTTCCGGCGCCGACGCCATCGCGCTGGGATTCGCCGACCACTTCGT
GCCACACGGCGACCTCGATGCGTTCACGCAGAAGATCGTCACCGGCGGCGTGGAGAGCGCATTGGCCGCCCACGCCGTCG
AACCTCCACCGAGCACGCTTGCCGCCCAACGTGATTGGATCGACGAATGCTATGCCGGCGACAGCGTCGCCGACATCGTT
GCGGCGCTGCGGAAACAGGGCGGCGAACCAGCCGTAAATGCTTCCGACCTGATTGCCAGCCGCTCCCCCATCGCGCTGTC
GGTGACGTTGCAGGCAGTGCGTCGCGCCGCCAAACTCGACACGCTAGAAGACGTGTTGATCCAGGACTATCGGGTGTCAT
CGGCGTCGCTGCGCTCGCATGACCTGGTGGAGGGCATCCGCGCGCAGTTGATCGACAAGGATCGCAACCCGAACTGGTCG
CCGGCAACCCTGGACGCGATCACGGCGGCCGACATCGAAGCCTATTTCGAACCGGTCGACGATGACTTGAGTTTCTAG

Upstream 100 bases:

>100_bases
GTTGTCATCCGGGTACACGATAAACCTTAGCCCCCGCGGGCACCGCTGGGCGAGCCACGATCTAGATTGCTGGTCAAACT
CTTCAGGGGAGGCGAGGCCC

Downstream 100 bases:

>100_bases
AGAGGTAGCGCATGACGTACGAAACCATCCTGGTCGAGCGCGATCAGCGAGTTGGCATTATCACGCTGAACCGTCCCCAG
GCACTGAACGCGCTCAACAG

Product: 3-hydroxyisobutyryl-CoA hydrolase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSWEHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKD
GVEARRFWRHEYLLNALIGRFAKPYVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGA
LGLHAALTGAPFSGADAIALGFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADIV
AALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQDYRVSSASLRSHDLVEGIRAQLIDKDRNPNWS
PATLDAITAADIEAYFEPVDDDLSF

Sequences:

>Translated_345_residues
MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSWEHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKD
GVEARRFWRHEYLLNALIGRFAKPYVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGA
LGLHAALTGAPFSGADAIALGFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADIV
AALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQDYRVSSASLRSHDLVEGIRAQLIDKDRNPNWS
PATLDAITAADIEAYFEPVDDDLSF
>Mature_344_residues
TGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSWEHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKDG
VEARRFWRHEYLLNALIGRFAKPYVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGAL
GLHAALTGAPFSGADAIALGFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADIVA
ALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQDYRVSSASLRSHDLVEGIRAQLIDKDRNPNWSP
ATLDAITAADIEAYFEPVDDDLSF

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=356, Percent_Identity=36.7977528089888, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI37594469, Length=307, Percent_Identity=35.1791530944625, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI194097323, Length=176, Percent_Identity=31.8181818181818, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1787660, Length=271, Percent_Identity=30.6273062730627, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI221142681, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788682, Length=181, Percent_Identity=27.0718232044199, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=350, Percent_Identity=38, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25144157, Length=350, Percent_Identity=38, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17540714, Length=243, Percent_Identity=26.7489711934156, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=306, Percent_Identity=23.202614379085, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=179, Percent_Identity=25.1396648044693, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17549921, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=351, Percent_Identity=31.6239316239316, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28571729, Length=342, Percent_Identity=35.672514619883, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28571730, Length=342, Percent_Identity=35.672514619883, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129971, Length=180, Percent_Identity=29.4444444444444, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653477, Length=180, Percent_Identity=29.4444444444444, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653139, Length=190, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 36354; Mature: 36223

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSWEHEDAVHAVVLSGAG
CCCCCCHHHEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
ERGLCAGGDVVAVYHSARKDGVEARRFWRHEYLLNALIGRFAKPYVALMDGIVMGGGVGV
CCCCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
SAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGALGLHAALTGAPFSGADAIAL
ECCCCCEEEECCCHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCEEEE
GFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADIV
CHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
AALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQDYRVSSASLRSH
HHHHHCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPVDDDLSF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSWEHEDAVHAVVLSGAG
CCCCCHHHEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
ERGLCAGGDVVAVYHSARKDGVEARRFWRHEYLLNALIGRFAKPYVALMDGIVMGGGVGV
CCCCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEE
SAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGALGLHAALTGAPFSGADAIAL
ECCCCCEEEECCCHHCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCEEEE
GFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADIV
CHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
AALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQDYRVSSASLRSH
HHHHHCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPVDDDLSF
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]