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The map label for this gene is fadA3 [H]

Identifier: 121637003

GI number: 121637003

Start: 1229455

End: 1230672

Strand: Reverse

Name: fadA3 [H]

Synonym: BCG_1132c

Alternate gene names: 121637003

Gene position: 1230672-1229455 (Counterclockwise)

Preceding gene: 121637004

Following gene: 121637000

Centisome position: 28.13

GC content: 65.27

Gene sequence:

>1218_bases
ATGCCAGAAGCTGTCATCGTCTCGACTGCCCGCTCGCCGATTGGCCGGGCCATGAAAGGATCGCTGGTCGGCATGCGGCC
CGACGACCTGGCCGTCCAGATGGTGCGCGCCGCGCTCGACAAGGTTCCGGCACTGAACCCCCATCAGATCGACGACCTCA
TGATGGGCTGTGGCCTGCCAGGCGGTGAGTCCGGTTTCAACATCGCCCGTGTCGTCGCCGTCGCGCTCGGCTATGACTTC
CTGCCGGGCACCACGGTCAACCGGTACTGTTCGTCGTCGCTGCAGACCACCCGGATGGCCTTCCACGCGATCAAGGCCGG
TGAGGGCGACGCGTTCATCTCCGCGGGCGTGGAAACCGTCTCCCGGTTCGCCAAGGGAAACTCCGACTCCTGGCCGGACA
CCAAGAACCCGCTGTTCGACGGGGCTCAGGAACGTTCGGCCGCGGCAGCCGCCGGCGCCGACGAATGGCACGATCCCCGC
ACCGATCAGAAGCTGCCGGACATCTATATTGCGATGGGCCAGACCGCGGAAAACGTCGCCATCATGACCGGCATCAGCCG
CGAAGAACAGGACCGCTGGGGCGTGCGCAGCCAGAACCGGGCCGAAGAGGCGATCAAGAACGGGTTCTTCGAACGAGAAA
TCACGCCGGTCACCCTTCCGGACGGCACCACGGTCAGCACCGACGACGGCCCGCGACCGGGTACCACCTACGAAAAGGTC
AGCGAGCTCAAGCCGGCTTTCCGGCCGAATGGCACCGTGACCGCGGGGAATGCCTGTCCGCTCAACGACGGGGCCGCCGC
GGTGGTGATCACCAGCGACACCAAGGCCAAGGAATTAGGCTTGACACCGCTGGCGCGCATTGTGTCCACCGGGGTCAGCG
GGCTGTCCCCGGAGATCATGGGCTTAGGGCCGATCGAGGCGTCCAAGAAGGCGCTGGAAAGAGCCGGGATGGCGATCACC
GACATCGACCTGGTCGAGATCAACGAGGCCTTCGCGGTGCAGGTCCTGGGCTCGGCGCGCGAGCTGGGCATCGACGAGGA
CAAGCTCAACATCTCAGGTGGCGCGATCGCCCTAGGTCACCCGTTCGGTATGACGGGTGCGCGCATCACCACCACGCTGT
TGAACAACCTGCAGACCTACGACAAGACGTTCGGTCTGGAAACCATGTGTGTCGGTGGCGGCCAGGGCATGGCGATGGTG
ATCGAGCGCCTCGCGTGA

Upstream 100 bases:

>100_bases
CGGCTGCGGCGGCCCCGGCCGGCCCGGGCCGTGCCGACCGGTGGGTAGCGACTACATTTGACCTAAACTTCACCACGTCT
TGTCCATGCCGGGAGCCGTC

Downstream 100 bases:

>100_bases
GCGAGGCGCTCGAGTGCGTTGACTCTGCGTCCACCACGCAAAAGTGCGAGTAGGACACGTGGTGGGCGCAGAGTCAACGT
CGTGATGTCAACGTGTCCCA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF
LPGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPR
TDQKLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVSTDDGPRPGTTYEKV
SELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAIT
DIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMV
IERLA

Sequences:

>Translated_405_residues
MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDF
LPGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPR
TDQKLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVSTDDGPRPGTTYEKV
SELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAIT
DIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMV
IERLA
>Mature_404_residues
PEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDFL
PGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETVSRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPRT
DQKLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVSTDDGPRPGTTYEKVS
ELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITD
IDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVI
ERLA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=412, Percent_Identity=38.3495145631068, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI167614485, Length=404, Percent_Identity=36.8811881188119, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI4501853, Length=410, Percent_Identity=38.780487804878, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4557237, Length=413, Percent_Identity=35.1089588377724, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=30.1176470588235, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI194353979, Length=402, Percent_Identity=29.6019900497512, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1787663, Length=415, Percent_Identity=42.8915662650602, Blast_Score=305, Evalue=5e-84,
Organism=Escherichia coli, GI48994986, Length=413, Percent_Identity=42.1307506053269, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1788554, Length=409, Percent_Identity=42.0537897310513, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87082165, Length=411, Percent_Identity=39.1727493917275, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=33.0985915492958, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=405, Percent_Identity=35.8024691358025, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI25147385, Length=409, Percent_Identity=32.7628361858191, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=407, Percent_Identity=34.3980343980344, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=444, Percent_Identity=31.5315315315315, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=407, Percent_Identity=28.009828009828, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=36.8811881188119, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6325229, Length=411, Percent_Identity=36.4963503649635, Blast_Score=206, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24655093, Length=414, Percent_Identity=37.1980676328502, Blast_Score=256, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=36.6336633663366, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24640423, Length=414, Percent_Identity=32.6086956521739, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17137578, Length=410, Percent_Identity=31.4634146341463, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42656; Mature: 42525

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00737 THIOLASE_2 ; PS00445 FGGY_KINASES_2 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLP
CCCCEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
GGESGFNIARVVAVALGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETV
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVA
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEE
IMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVSTDDGPRPGTTYEKV
EEECCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCEECCCCCCCCCCHHHHH
SELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIM
HHCCCCCCCCCCEECCCCCCCCCCCEEEEEECCCCHHHCCCHHHHHHHHHCCCCCCCCCE
GLGPIEASKKALERAGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGH
ECCCCHHHHHHHHHCCCEEEEEEEEECCCHHEEEECCCHHHCCCCCCCEEECCCEEEECC
PFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHC
>Mature Secondary Structure 
PEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLP
CCCEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
GGESGFNIARVVAVALGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETV
CCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
SRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVA
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEE
IMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVSTDDGPRPGTTYEKV
EEECCCCHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCEECCCCCCCCCCHHHHH
SELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIM
HHCCCCCCCCCCEECCCCCCCCCCCEEEEEECCCCHHHCCCHHHHHHHHHCCCCCCCCCE
GLGPIEASKKALERAGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGH
ECCCCHHHHHHHHHCCCEEEEEEEEECCCHHEEEECCCHHHCCCCCCCEEECCCEEEECC
PFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]