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The map label for this gene is aceK

Identifier: 120613005

GI number: 120613005

Start: 4854791

End: 4856599

Strand: Reverse

Name: aceK

Synonym: Aave_4369

Alternate gene names: 120613005

Gene position: 4856599-4854791 (Counterclockwise)

Preceding gene: 120613006

Following gene: 120613004

Centisome position: 90.73

GC content: 63.46

Gene sequence:

>1809_bases
ATGTTCCCACGGCGTCTCGATTCTCCTGCCGCCTACGGCATCGCGCAGGCGATGATGGACGGCTTCGATCGCCACTACAG
GCTGTTCCGTGCCGAGTCGGCGCGTGCGAAGCACCGCTTCGAGACGTCCGACTGGTCAGGCCAGCAGCGCGCGCAGCGCG
AGCGCATCGAGTTCTACGACCTGCGCGTGAAGGAGTGCGTGCGCAGGCTCGAAAAGGAATTTTCCGCGGGGGCGCAGCCG
ATGGACGTGTGGCACCAGGTGAAGCTGCATTACATCGGCCTGCTGGTGGGGCACCGGCAGCCCGAACTGGCCGAGACGTT
CTTCAATTCGGTCACGACCAAGATCCTGCACCGCACGCACTTCCACAATGATTTCATCTTCGTGCGGCCGGCCATCAGCA
CGGAGTACCTGGAAAACGACGAGCCCGGGGCGCGGCCGACCTACCGGGCCTACTACCCCACGCCCGAGTCGTTGCAGGAG
ACGCTGGTGCGTGTCGTGGACAACTTCCAGCTGCAGGGCGAGTTCGAGGATCTTGCGCGCGATGCCGGGCGTGTGGCGGA
GGTGATGCGGCCGCGGCTCGGGCCGGCGAAGTGGCGTGCGAATTTCCAGATCCAGGTGCTGTCCAGCCTGTTCTATCGCA
ACAAGGGCGCTTACCTGGTGGGCAAGGTGATCAACGGGTTCCAGGAACTGGCTTTCGCGCTGCCCATCCTGCACGGTACC
GATGGCCGCTACGTGATCGATGCGGCGCTGTTCGGCGAGGACGACCTGCAGATGCTGTTCAGCTTCGCCCGGGCCTATTT
CATGGTGGACATGGAGATTCCGAGCGCGTACGTGCAGTTTCTGCGCAGCCTGATGCCCCGCAAGCCGCGGGCGGAGCTCT
ACAACGCCCTGGGGCTTGCCAAGCAGGGCAAGACGCTTTTCTACCGGGATTTCCTGCACCACCTGCGCTACTCGAGCGAT
CGCTTCCGCATCGCGCCGGGGATCAAGGGGATGGTGATGCTGGTGTTCGACCTGCCGTCGTTCCCGTTCGTGTTCAAGGT
CATCAAGGATTACTACCCGCCCCAGAAGGACACCACGCGGGAGCAGATCAAGGGCAAGTACCTGCTGGTGAAGCAGCACG
ACCGGGTGGGCCGGATGGCGGACACGCTGGAGTACAGCGAGGTGGCCTTCCCGCGCGAGCGCTTCGAGGACGATCTGATC
GCCGAGATAGAGAAATTCGCACCCAGCCAGCTGGAGATCAGCGACCGCGACGGCGACGGGAATGTCGAGGTGATCCTCAA
GCACGTGTATATCGAGCGGCGGATGATTCCACTCAACATCTACCTGCAGGAGGCGTTCGATGCGGGTCCGCACGATGCGC
GCGCACGGCAGCAGATGGAGCGCAGCGTGGTCGAGTACGGCAATGCGATCAAGGATCTGGTGGCGGCCAACATCTTTCCC
GGCGACATGCTGTGGAAGAACTTCGGCGTCACCCGCAACGGCAAGGTCGTTTTCTACGACTACGACGAGATCGAATACCT
CACCGATTGCCATTTCCGGAGGGTGCCAGCCCCGCGCAACGAAGAGGACGAGCTTTCGGGCGAGGTCTGGTGGGCCGTGG
GGCCGCGCGACGTGTTCCCGGAGACTTTCGGGCCTTTCCTGCTGGGCAACGATGCCGTGCGGGAGGTGTTCATGCGCCAC
CATGCGGACCTGCTCGATCCGGTCTTCTGGCAATCGCACAAGGAGCGCATACAGGCCGGGCACATGTACGACGTATTTCC
CTACGACCCTGAGCGGCGCTTCGGCGCCGGCACCGGTTCGCCGGCCTGA

Upstream 100 bases:

>100_bases
CTGGATTCCGTGTACAAGGCGGCGATCCAGGGCGTGGCCAACCGCCTGCGGGGGTAGGTCGCCACCACTTTCCGGCAACG
TGTCGATGGAGCAAGCAGCC

Downstream 100 bases:

>100_bases
CTCCCATGCCGCGCGGCGGCGGGCCTGCCCCCTGCGCTGTTCTTCACTGACCCGTACCCAGCAATTTCACAGGAGACTCC
GAATGCAGCAAGATCCCATC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase protein

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MFPRRLDSPAAYGIAQAMMDGFDRHYRLFRAESARAKHRFETSDWSGQQRAQRERIEFYDLRVKECVRRLEKEFSAGAQP
MDVWHQVKLHYIGLLVGHRQPELAETFFNSVTTKILHRTHFHNDFIFVRPAISTEYLENDEPGARPTYRAYYPTPESLQE
TLVRVVDNFQLQGEFEDLARDAGRVAEVMRPRLGPAKWRANFQIQVLSSLFYRNKGAYLVGKVINGFQELAFALPILHGT
DGRYVIDAALFGEDDLQMLFSFARAYFMVDMEIPSAYVQFLRSLMPRKPRAELYNALGLAKQGKTLFYRDFLHHLRYSSD
RFRIAPGIKGMVMLVFDLPSFPFVFKVIKDYYPPQKDTTREQIKGKYLLVKQHDRVGRMADTLEYSEVAFPRERFEDDLI
AEIEKFAPSQLEISDRDGDGNVEVILKHVYIERRMIPLNIYLQEAFDAGPHDARARQQMERSVVEYGNAIKDLVAANIFP
GDMLWKNFGVTRNGKVVFYDYDEIEYLTDCHFRRVPAPRNEEDELSGEVWWAVGPRDVFPETFGPFLLGNDAVREVFMRH
HADLLDPVFWQSHKERIQAGHMYDVFPYDPERRFGAGTGSPA

Sequences:

>Translated_602_residues
MFPRRLDSPAAYGIAQAMMDGFDRHYRLFRAESARAKHRFETSDWSGQQRAQRERIEFYDLRVKECVRRLEKEFSAGAQP
MDVWHQVKLHYIGLLVGHRQPELAETFFNSVTTKILHRTHFHNDFIFVRPAISTEYLENDEPGARPTYRAYYPTPESLQE
TLVRVVDNFQLQGEFEDLARDAGRVAEVMRPRLGPAKWRANFQIQVLSSLFYRNKGAYLVGKVINGFQELAFALPILHGT
DGRYVIDAALFGEDDLQMLFSFARAYFMVDMEIPSAYVQFLRSLMPRKPRAELYNALGLAKQGKTLFYRDFLHHLRYSSD
RFRIAPGIKGMVMLVFDLPSFPFVFKVIKDYYPPQKDTTREQIKGKYLLVKQHDRVGRMADTLEYSEVAFPRERFEDDLI
AEIEKFAPSQLEISDRDGDGNVEVILKHVYIERRMIPLNIYLQEAFDAGPHDARARQQMERSVVEYGNAIKDLVAANIFP
GDMLWKNFGVTRNGKVVFYDYDEIEYLTDCHFRRVPAPRNEEDELSGEVWWAVGPRDVFPETFGPFLLGNDAVREVFMRH
HADLLDPVFWQSHKERIQAGHMYDVFPYDPERRFGAGTGSPA
>Mature_602_residues
MFPRRLDSPAAYGIAQAMMDGFDRHYRLFRAESARAKHRFETSDWSGQQRAQRERIEFYDLRVKECVRRLEKEFSAGAQP
MDVWHQVKLHYIGLLVGHRQPELAETFFNSVTTKILHRTHFHNDFIFVRPAISTEYLENDEPGARPTYRAYYPTPESLQE
TLVRVVDNFQLQGEFEDLARDAGRVAEVMRPRLGPAKWRANFQIQVLSSLFYRNKGAYLVGKVINGFQELAFALPILHGT
DGRYVIDAALFGEDDLQMLFSFARAYFMVDMEIPSAYVQFLRSLMPRKPRAELYNALGLAKQGKTLFYRDFLHHLRYSSD
RFRIAPGIKGMVMLVFDLPSFPFVFKVIKDYYPPQKDTTREQIKGKYLLVKQHDRVGRMADTLEYSEVAFPRERFEDDLI
AEIEKFAPSQLEISDRDGDGNVEVILKHVYIERRMIPLNIYLQEAFDAGPHDARARQQMERSVVEYGNAIKDLVAANIFP
GDMLWKNFGVTRNGKVVFYDYDEIEYLTDCHFRRVPAPRNEEDELSGEVWWAVGPRDVFPETFGPFLLGNDAVREVFMRH
HADLLDPVFWQSHKERIQAGHMYDVFPYDPERRFGAGTGSPA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family

Homologues:

Organism=Escherichia coli, GI1790446, Length=591, Percent_Identity=39.424703891709, Blast_Score=415, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACEK_ACIAC (A1TVC1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972683.1
- STRING:   A1TVC1
- GeneID:   4668089
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4369
- NMPDR:   fig|397945.5.peg.3753
- eggNOG:   COG4579
- HOGENOM:   HBG298593
- PhylomeDB:   A1TVC1
- ProtClustDB:   PRK02946
- BioCyc:   AAVE397945:AAVE_4369-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00747
- InterPro:   IPR010452
- PIRSF:   PIRSF000719
- ProDom:   PD043552

Pfam domain/function: PF06315 AceK

EC number: =2.7.11.5

Molecular weight: Translated: 70102; Mature: 70102

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: ACT_SITE 381-381 BINDING 346-346

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPRRLDSPAAYGIAQAMMDGFDRHYRLFRAESARAKHRFETSDWSGQQRAQRERIEFYD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LRVKECVRRLEKEFSAGAQPMDVWHQVKLHYIGLLVGHRQPELAETFFNSVTTKILHRTH
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FHNDFIFVRPAISTEYLENDEPGARPTYRAYYPTPESLQETLVRVVDNFQLQGEFEDLAR
CCCCEEEEECCCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHH
DAGRVAEVMRPRLGPAKWRANFQIQVLSSLFYRNKGAYLVGKVINGFQELAFALPILHGT
HHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHEECC
DGRYVIDAALFGEDDLQMLFSFARAYFMVDMEIPSAYVQFLRSLMPRKPRAELYNALGLA
CCCEEEEEEECCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHH
KQGKTLFYRDFLHHLRYSSDRFRIAPGIKGMVMLVFDLPSFPFVFKVIKDYYPPQKDTTR
HCCCHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCH
EQIKGKYLLVKQHDRVGRMADTLEYSEVAFPRERFEDDLIAEIEKFAPSQLEISDRDGDG
HHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHCCCCCEEEECCCCCC
NVEVILKHVYIERRMIPLNIYLQEAFDAGPHDARARQQMERSVVEYGNAIKDLVAANIFP
CHHHHHHHHHHHCEEEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDMLWKNFGVTRNGKVVFYDYDEIEYLTDCHFRRVPAPRNEEDELSGEVWWAVGPRDVFP
CHHHHHHCCCCCCCEEEEEECCHHHHHHHCHHCCCCCCCCCCCCCCCEEEEEECCHHCCC
ETFGPFLLGNDAVREVFMRHHADLLDPVFWQSHKERIQAGHMYDVFPYDPERRFGAGTGS
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
PA
CC
>Mature Secondary Structure
MFPRRLDSPAAYGIAQAMMDGFDRHYRLFRAESARAKHRFETSDWSGQQRAQRERIEFYD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LRVKECVRRLEKEFSAGAQPMDVWHQVKLHYIGLLVGHRQPELAETFFNSVTTKILHRTH
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
FHNDFIFVRPAISTEYLENDEPGARPTYRAYYPTPESLQETLVRVVDNFQLQGEFEDLAR
CCCCEEEEECCCCHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHH
DAGRVAEVMRPRLGPAKWRANFQIQVLSSLFYRNKGAYLVGKVINGFQELAFALPILHGT
HHHHHHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHEECC
DGRYVIDAALFGEDDLQMLFSFARAYFMVDMEIPSAYVQFLRSLMPRKPRAELYNALGLA
CCCEEEEEEECCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHH
KQGKTLFYRDFLHHLRYSSDRFRIAPGIKGMVMLVFDLPSFPFVFKVIKDYYPPQKDTTR
HCCCHHHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCH
EQIKGKYLLVKQHDRVGRMADTLEYSEVAFPRERFEDDLIAEIEKFAPSQLEISDRDGDG
HHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHCCCCCEEEECCCCCC
NVEVILKHVYIERRMIPLNIYLQEAFDAGPHDARARQQMERSVVEYGNAIKDLVAANIFP
CHHHHHHHHHHHCEEEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDMLWKNFGVTRNGKVVFYDYDEIEYLTDCHFRRVPAPRNEEDELSGEVWWAVGPRDVFP
CHHHHHHCCCCCCCEEEEEECCHHHHHHHCHHCCCCCCCCCCCCCCCEEEEEECCHHCCC
ETFGPFLLGNDAVREVFMRHHADLLDPVFWQSHKERIQAGHMYDVFPYDPERRFGAGTGS
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCC
PA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA