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The map label for this gene is thlA [H]

Identifier: 120613004

GI number: 120613004

Start: 4853524

End: 4854708

Strand: Reverse

Name: thlA [H]

Synonym: Aave_4368

Alternate gene names: 120613004

Gene position: 4854708-4853524 (Counterclockwise)

Preceding gene: 120613005

Following gene: 120613003

Centisome position: 90.7

GC content: 68.61

Gene sequence:

>1185_bases
ATGCAGCAAGATCCCATCGTCATCATCGGTGCCGCACGTACGCCCATGGGGACTTTCCAGGGCGATTTCTCGGGCCTGGC
TGCCCATGACCTGGGAGGCGTGGCGATCCGTGCGGCCGTGGAGCGCGCAGGCATCGCGCCGGAGAGCGTCGGCGAGGTGC
TGTTCGGCAATTGCCTGATGGCGGGGCAGGGGCAGGCGCCGGCCCGACAGGCCGGGTTCAAGGGCGGGCTGCCCAAGAGC
GCCGGAGCCGTCACGTTGAGCAAGATGTGCGGTTCGGGCATGAAGGCCGCGATGTTCGCGCACGACATGCTCCTCGCAGG
GACGCACGAAGTGATCGTGGCCGGCGGGATGGAGAGCATGACGAATGCGCCCTATCTGCTGCAGAAGGGCCGCGGCGGCT
ACCGGCTGGGCCACGACCGCATCTTCGACCACATGATGCTCGACGGGCTGGAGGACGCCTACGAGCCCGGACGCTCGATG
GGTACGTTCGGCGAGGATTGCGCGGCGAAGTACGGGTTCACGCGCGAGCAGCAGGATGCATTCGCCGTGGCGAGCGTGCA
GCGGGCGAAGGCGGCGACCGAATCCGGGGCGTTTGCGGCCGAGATCGCACCGGTGACCGTGAAGACGCGTGCCGGCGAGA
CGGTGGTGTCGGTGGACGAGGGACCGGGCAAGGTGCGGCTGGACAAGATTCCCGCGCTCAAGCCGGCGTTCAAGAAGGAC
GGGACCATCACGGCGGCATCGAGTTCGAGCATCAACGACGGCGCCGCGGCGCTGGTGATGGTGCGCGAGTCCACGGCCCG
CCGTCTCGGCGCCGTGCCGATCGCGCGCGTCGCGGGCCATGCCATGCATGCGCAGGAGCCCAATTGGTTCACCACCGCGC
CCGTGGGTGCCACGCAGAAGGCGCTGGCCAAGGCCGGCTGGAGCGTGCAGGACGTGGACCTCTGGGAGGTGAACGAAGCC
TTCGCGGTGGTGCCCATGGCGCTCATGAAGGAGCTGGACGTGGCGCATGACATCGTGAACGTGAACGGCGGAGCCTGCGC
GCTGGGGCACCCGATCGGAGCGAGTGGGGCCCGCATCATCGTGACCCTGATCCATGCCTTGAAGGCCCGTGGCAAGCGGC
GCGGGCTGGCCACGCTGTGCATCGGCGGTGGCGAAGGCACGGCCATGGCGATCGAACTGGTGTGA

Upstream 100 bases:

>100_bases
ACCGGTTCGCCGGCCTGACTCCCATGCCGCGCGGCGGCGGGCCTGCCCCCTGCGCTGTTCTTCACTGACCCGTACCCAGC
AATTTCACAGGAGACTCCGA

Downstream 100 bases:

>100_bases
GCGCTGCCGTGTCGGAGGAGCGCTCCAGCCATCCGGTGCTGGTCATCGGGGCTTCCCGGGGCATCGGCCTGGAGTTCGTG
CGCCAGTACCGCGAGGCGGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MQQDPIVIIGAARTPMGTFQGDFSGLAAHDLGGVAIRAAVERAGIAPESVGEVLFGNCLMAGQGQAPARQAGFKGGLPKS
AGAVTLSKMCGSGMKAAMFAHDMLLAGTHEVIVAGGMESMTNAPYLLQKGRGGYRLGHDRIFDHMMLDGLEDAYEPGRSM
GTFGEDCAAKYGFTREQQDAFAVASVQRAKAATESGAFAAEIAPVTVKTRAGETVVSVDEGPGKVRLDKIPALKPAFKKD
GTITAASSSSINDGAAALVMVRESTARRLGAVPIARVAGHAMHAQEPNWFTTAPVGATQKALAKAGWSVQDVDLWEVNEA
FAVVPMALMKELDVAHDIVNVNGGACALGHPIGASGARIIVTLIHALKARGKRRGLATLCIGGGEGTAMAIELV

Sequences:

>Translated_394_residues
MQQDPIVIIGAARTPMGTFQGDFSGLAAHDLGGVAIRAAVERAGIAPESVGEVLFGNCLMAGQGQAPARQAGFKGGLPKS
AGAVTLSKMCGSGMKAAMFAHDMLLAGTHEVIVAGGMESMTNAPYLLQKGRGGYRLGHDRIFDHMMLDGLEDAYEPGRSM
GTFGEDCAAKYGFTREQQDAFAVASVQRAKAATESGAFAAEIAPVTVKTRAGETVVSVDEGPGKVRLDKIPALKPAFKKD
GTITAASSSSINDGAAALVMVRESTARRLGAVPIARVAGHAMHAQEPNWFTTAPVGATQKALAKAGWSVQDVDLWEVNEA
FAVVPMALMKELDVAHDIVNVNGGACALGHPIGASGARIIVTLIHALKARGKRRGLATLCIGGGEGTAMAIELV
>Mature_394_residues
MQQDPIVIIGAARTPMGTFQGDFSGLAAHDLGGVAIRAAVERAGIAPESVGEVLFGNCLMAGQGQAPARQAGFKGGLPKS
AGAVTLSKMCGSGMKAAMFAHDMLLAGTHEVIVAGGMESMTNAPYLLQKGRGGYRLGHDRIFDHMMLDGLEDAYEPGRSM
GTFGEDCAAKYGFTREQQDAFAVASVQRAKAATESGAFAAEIAPVTVKTRAGETVVSVDEGPGKVRLDKIPALKPAFKKD
GTITAASSSSINDGAAALVMVRESTARRLGAVPIARVAGHAMHAQEPNWFTTAPVGATQKALAKAGWSVQDVDLWEVNEA
FAVVPMALMKELDVAHDIVNVNGGACALGHPIGASGARIIVTLIHALKARGKRRGLATLCIGGGEGTAMAIELV

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=46.7866323907455, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=44.6428571428571, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=37.7892030848329, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI4501853, Length=381, Percent_Identity=36.2204724409449, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4504327, Length=421, Percent_Identity=29.6912114014252, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=28.2776349614396, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1788554, Length=388, Percent_Identity=51.8041237113402, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=44.5012787723785, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1787663, Length=392, Percent_Identity=37.2448979591837, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI48994986, Length=414, Percent_Identity=34.7826086956522, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=30.9859154929577, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=42.0779220779221, Blast_Score=305, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=43.6548223350254, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=38.974358974359, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=32.3979591836735, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=29.9287410926366, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=42.25, Blast_Score=299, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=32.0610687022901, Blast_Score=169, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=44.5876288659794, Blast_Score=324, Evalue=7e-89,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=44.7300771208226, Blast_Score=307, Evalue=7e-84,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=34.1836734693878, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI17137578, Length=421, Percent_Identity=28.5035629453682, Blast_Score=158, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40688; Mature: 40688

Theoretical pI: Translated: 7.62; Mature: 7.62

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQDPIVIIGAARTPMGTFQGDFSGLAAHDLGGVAIRAAVERAGIAPESVGEVLFGNCLM
CCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCEEE
AGQGQAPARQAGFKGGLPKSAGAVTLSKMCGSGMKAAMFAHDMLLAGTHEVIVAGGMESM
ECCCCCCHHHCCCCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHH
TNAPYLLQKGRGGYRLGHDRIFDHMMLDGLEDAYEPGRSMGTFGEDCAAKYGFTREQQDA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHH
FAVASVQRAKAATESGAFAAEIAPVTVKTRAGETVVSVDEGPGKVRLDKIPALKPAFKKD
HHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCCC
GTITAASSSSINDGAAALVMVRESTARRLGAVPIARVAGHAMHAQEPNWFTTAPVGATQK
CCEEEECCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHCHHHCCCCCCCEEECCCCHHHH
ALAKAGWSVQDVDLWEVNEAFAVVPMALMKELDVAHDIVNVNGGACALGHPIGASGARII
HHHHCCCCEECCCCEECCCHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCHHHH
VTLIHALKARGKRRGLATLCIGGGEGTAMAIELV
HHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MQQDPIVIIGAARTPMGTFQGDFSGLAAHDLGGVAIRAAVERAGIAPESVGEVLFGNCLM
CCCCCEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCHHHHHHHHHCCEEE
AGQGQAPARQAGFKGGLPKSAGAVTLSKMCGSGMKAAMFAHDMLLAGTHEVIVAGGMESM
ECCCCCCHHHCCCCCCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHH
TNAPYLLQKGRGGYRLGHDRIFDHMMLDGLEDAYEPGRSMGTFGEDCAAKYGFTREQQDA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCHHHH
FAVASVQRAKAATESGAFAAEIAPVTVKTRAGETVVSVDEGPGKVRLDKIPALKPAFKKD
HHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCEEEEECCCCCEEEECCCCCCCCCCCCC
GTITAASSSSINDGAAALVMVRESTARRLGAVPIARVAGHAMHAQEPNWFTTAPVGATQK
CCEEEECCCCCCCCCEEEEEEECHHHHHHCCCHHHHHHCHHHCCCCCCCEEECCCCHHHH
ALAKAGWSVQDVDLWEVNEAFAVVPMALMKELDVAHDIVNVNGGACALGHPIGASGARII
HHHHCCCCEECCCCEECCCHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCCCCHHHH
VTLIHALKARGKRRGLATLCIGGGEGTAMAIELV
HHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]