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The map label for this gene is ttcA

Identifier: 120612867

GI number: 120612867

Start: 4688248

End: 4689180

Strand: Direct

Name: ttcA

Synonym: Aave_4231

Alternate gene names: 120612867

Gene position: 4688248-4689180 (Clockwise)

Preceding gene: 120612862

Following gene: 120612868

Centisome position: 87.59

GC content: 66.99

Gene sequence:

>933_bases
ATGACCGCCCTGCCACAAGACACCGACTGGACCGCCGACGCCTCCCGCCCCGCGCAGGCCCGGATCGAACGCGAGGCGCA
CAAGCTCGAGAAGCGCCTGTGCCGCGAGGTCGGCCGCGCCATCGTCGATTACCGCATGATCGAGGAGGGCGACAAGGTCA
TGGTGTGCATGTCCGGCGGCAAGGACAGCTACACCCTGCTGGACATCCTCATCAAGCTGCAGAAGCGAGCGCCCATCCAT
TTCGACCTGGTGGCCGTGAACCTCGACCAGAAGCAGCCGGGCTTCCCCGAGCACATCCTGCCCGAGTACCTGGCCGCCAC
CGGCGTGCCCTTCCACATCGAGAACCAGGACACCTACAGCATCGTCAAGCGGGTGGTGCCCGAAGGCAAGACCACCTGCG
GCCTGTGCAGCCGGCTGCGCCGCGGCATCCTCTACCGCGTGGCCGACGAGCTGGGCTGCACCAAGATCGCGCTGGGCCAC
CACCGCGACGACATCCTGCAGACGCTGCTGCTCAACATGTTCTTCGGCGGCAAGATGAAGGCCATGCCCCCGAAGCTCGT
CAGCGACGACGGCCGCCACGTGGTGATCCGCCCGCTGGCCTACGTGCCCGAGAAGGACACCACGCGGTGGGCCCAGCAGC
GGCAGTTCCCGATCATCCCGTGCAACCTCTGCGGCAGCCAGGAGAACCTGCAGCGCAAGCAGGTGGGCGAGATGCTGCGC
GACTGGGACAAGCGCTTCCCCGGCCGCGTGGACAACATGTTCAACGCGCTGCAGAACATCGTGCCGTCGCACCTGATGGA
TGGAACGCTGCACGACTTCCAGCATCTGAAGGCCACGGGCATCGCGAGCGACGACGGCGACAAGGCCTTCGACGCCGAGG
AGTTCCCCCCGGCGCCCGCCCTGCCGGGCCTGCAGGTGGTGCAGATTTCCTGA

Upstream 100 bases:

>100_bases
GAACGGGCGCCGCCGCACGGCGGCGCCGAGCGGAAGCGGGAAGCACCGCGCAGCCCGCGCGTGCCCTTCCTGCTTCCGCG
GACCCGATTGTCTCCCTCCC

Downstream 100 bases:

>100_bases
CACGCCGCGGCCCTCCGAGCGACCCGTGAAGCCCTCCCCTTCGTACCGGATTCCAGGAGACCGCCCATGAACGCCACCAC
CGCCGGGCTGCCCCGGCTCT

Product: PP-loop domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTALPQDTDWTADASRPAQARIEREAHKLEKRLCREVGRAIVDYRMIEEGDKVMVCMSGGKDSYTLLDILIKLQKRAPIH
FDLVAVNLDQKQPGFPEHILPEYLAATGVPFHIENQDTYSIVKRVVPEGKTTCGLCSRLRRGILYRVADELGCTKIALGH
HRDDILQTLLLNMFFGGKMKAMPPKLVSDDGRHVVIRPLAYVPEKDTTRWAQQRQFPIIPCNLCGSQENLQRKQVGEMLR
DWDKRFPGRVDNMFNALQNIVPSHLMDGTLHDFQHLKATGIASDDGDKAFDAEEFPPAPALPGLQVVQIS

Sequences:

>Translated_310_residues
MTALPQDTDWTADASRPAQARIEREAHKLEKRLCREVGRAIVDYRMIEEGDKVMVCMSGGKDSYTLLDILIKLQKRAPIH
FDLVAVNLDQKQPGFPEHILPEYLAATGVPFHIENQDTYSIVKRVVPEGKTTCGLCSRLRRGILYRVADELGCTKIALGH
HRDDILQTLLLNMFFGGKMKAMPPKLVSDDGRHVVIRPLAYVPEKDTTRWAQQRQFPIIPCNLCGSQENLQRKQVGEMLR
DWDKRFPGRVDNMFNALQNIVPSHLMDGTLHDFQHLKATGIASDDGDKAFDAEEFPPAPALPGLQVVQIS
>Mature_309_residues
TALPQDTDWTADASRPAQARIEREAHKLEKRLCREVGRAIVDYRMIEEGDKVMVCMSGGKDSYTLLDILIKLQKRAPIHF
DLVAVNLDQKQPGFPEHILPEYLAATGVPFHIENQDTYSIVKRVVPEGKTTCGLCSRLRRGILYRVADELGCTKIALGHH
RDDILQTLLLNMFFGGKMKAMPPKLVSDDGRHVVIRPLAYVPEKDTTRWAQQRQFPIIPCNLCGSQENLQRKQVGEMLRD
WDKRFPGRVDNMFNALQNIVPSHLMDGTLHDFQHLKATGIASDDGDKAFDAEEFPPAPALPGLQVVQIS

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=274, Percent_Identity=68.2481751824817, Blast_Score=403, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI193211090, Length=254, Percent_Identity=30.3149606299213, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17540090, Length=252, Percent_Identity=26.5873015873016, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24651972, Length=231, Percent_Identity=26.8398268398268, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_ACIAC (A1TUY3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972545.1
- ProteinModelPortal:   A1TUY3
- SMR:   A1TUY3
- STRING:   A1TUY3
- GeneID:   4665174
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4231
- NMPDR:   fig|397945.5.peg.3629
- eggNOG:   COG0037
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- PhylomeDB:   A1TUY3
- BioCyc:   AAVE397945:AAVE_4231-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 34947; Mature: 34816

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPQDTDWTADASRPAQARIEREAHKLEKRLCREVGRAIVDYRMIEEGDKVMVCMSGG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
KDSYTLLDILIKLQKRAPIHFDLVAVNLDQKQPGFPEHILPEYLAATGVPFHIENQDTYS
CCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCHHHH
IVKRVVPEGKTTCGLCSRLRRGILYRVADELGCTKIALGHHRDDILQTLLLNMFFGGKMK
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCC
AMPPKLVSDDGRHVVIRPLAYVPEKDTTRWAQQRQFPIIPCNLCGSQENLQRKQVGEMLR
CCCCHHHCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHHHHH
DWDKRFPGRVDNMFNALQNIVPSHLMDGTLHDFQHLKATGIASDDGDKAFDAEEFPPAPA
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LPGLQVVQIS
CCCCEEEEEC
>Mature Secondary Structure 
TALPQDTDWTADASRPAQARIEREAHKLEKRLCREVGRAIVDYRMIEEGDKVMVCMSGG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
KDSYTLLDILIKLQKRAPIHFDLVAVNLDQKQPGFPEHILPEYLAATGVPFHIENQDTYS
CCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCHHHH
IVKRVVPEGKTTCGLCSRLRRGILYRVADELGCTKIALGHHRDDILQTLLLNMFFGGKMK
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCCC
AMPPKLVSDDGRHVVIRPLAYVPEKDTTRWAQQRQFPIIPCNLCGSQENLQRKQVGEMLR
CCCCHHHCCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHHHHH
DWDKRFPGRVDNMFNALQNIVPSHLMDGTLHDFQHLKATGIASDDGDKAFDAEEFPPAPA
HHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LPGLQVVQIS
CCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA