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The map label for this gene is hpd [H]

Identifier: 120612827

GI number: 120612827

Start: 4642813

End: 4643949

Strand: Direct

Name: hpd [H]

Synonym: Aave_4191

Alternate gene names: 120612827

Gene position: 4642813-4643949 (Clockwise)

Preceding gene: 120612826

Following gene: 120612828

Centisome position: 86.74

GC content: 65.35

Gene sequence:

>1137_bases
ATGAACACCCCGCTGCCCCACCCCGCCGTCCAGGACACCGCCGCCTGGGAGAACCCGATGGGTACCGACGGCTTCGAATT
CATCGAATACGCCGCTCCCGATCCGCAGGCCATGGGCCGGGTGTTCGAGGGCATGGGCTTCAAGCCCGTGGCGCGCCACC
GCCACAAGAACGTGACGCTCTACCGCCAGGGCGAAATCAACTTCATCATCAACGCCGAGCCCGACAGTTTCGCGCAGCGT
TTCGCGCGGCTGCACGGCCCCAGCGTCTGCGCCATCGCCTTCCGCGTGCACGACGCCAAGGCCGCCTACGAGCGCGCGCT
GAACCTGGGTGCCTGGGGCTACGCCGGCCAGGCCGGCCCGGGCGAGCTGAACATTCCCGCCATCAAGGGCATCGGCGACA
GCCTGATCTACCTGGTGGACCGCTGGCGCGGCAAGAACGGCGCGCAACCGGGCGACATCGGCAACATCGGCTTCTTCGAC
GTCGATTTCGAGCCGCTGCCGGGCGTGACCGCCGAGGAGGCGCTGAATCCCAAGGGCCACGGCCTGACCTACATCGACCA
CCTGACGCACAACGTGCACCGCGGCCGGATGATCGAATGGGCGAACTTCTACGAGCGCCTGTTCAACTTCCGCGAGATCC
GCTACTTCGACATCGAAGGCCAGGTCACCGGCGTGAAGAGCAAGGCCATGACCAGCCCCTGCGGCAAGATCCGCATCCCG
ATCAACGAAGAGGGCAAGGAAAAGGCCGGCCAGATCCAGGAATACCTGGACATGTACAACGGCGAGGGCATCCAGCACAT
CGCCATGGGCTCGGACGACCTCTACGCCACGGTGGACGCCCTGCGCGGCTCCGGCGTGCGCCTGCTGGACACGATCGACA
CCTACTACGAGCTGGTGGACAAGCGCATTCCCGGCCACGGCGAGAGCGTGGAAGAGCTGCACAAGCGCAAGATCCTGATC
GACGGCAAGAAGGACGCGATCCTGCTGCAGATCTTCAGCGAAAACCAGCTCGGCCCGATCTTCTTCGAGTTCATCCAGCG
CAAGGGGGACGACGGCTTCGGCAACGGCAACTTCAAGGCGCTGTTCGAGAGCATCGAGCTCGACCAGATGCGCCGCGGGG
TGCTGCAGGGCGCCTGA

Upstream 100 bases:

>100_bases
ACAGGCCCGGCAACGTTGCGATGTTTATGCCAGAAACATGAGCCTGCGTGCGCCTACAGTGGCATGACGCAGATCAACGC
GCCAACCCCGGAGACAACGC

Downstream 100 bases:

>100_bases
AAGAACGCCTAAAGCCATTGGCAGGCCGATTGACGTAACCAACTGCATCGGCATGGCCCCCGTCTCTATACTGCGCCGTC
CCAATGAGCACGAGAGAGAG

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MNTPLPHPAVQDTAAWENPMGTDGFEFIEYAAPDPQAMGRVFEGMGFKPVARHRHKNVTLYRQGEINFIINAEPDSFAQR
FARLHGPSVCAIAFRVHDAKAAYERALNLGAWGYAGQAGPGELNIPAIKGIGDSLIYLVDRWRGKNGAQPGDIGNIGFFD
VDFEPLPGVTAEEALNPKGHGLTYIDHLTHNVHRGRMIEWANFYERLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIP
INEEGKEKAGQIQEYLDMYNGEGIQHIAMGSDDLYATVDALRGSGVRLLDTIDTYYELVDKRIPGHGESVEELHKRKILI
DGKKDAILLQIFSENQLGPIFFEFIQRKGDDGFGNGNFKALFESIELDQMRRGVLQGA

Sequences:

>Translated_378_residues
MNTPLPHPAVQDTAAWENPMGTDGFEFIEYAAPDPQAMGRVFEGMGFKPVARHRHKNVTLYRQGEINFIINAEPDSFAQR
FARLHGPSVCAIAFRVHDAKAAYERALNLGAWGYAGQAGPGELNIPAIKGIGDSLIYLVDRWRGKNGAQPGDIGNIGFFD
VDFEPLPGVTAEEALNPKGHGLTYIDHLTHNVHRGRMIEWANFYERLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIP
INEEGKEKAGQIQEYLDMYNGEGIQHIAMGSDDLYATVDALRGSGVRLLDTIDTYYELVDKRIPGHGESVEELHKRKILI
DGKKDAILLQIFSENQLGPIFFEFIQRKGDDGFGNGNFKALFESIELDQMRRGVLQGA
>Mature_378_residues
MNTPLPHPAVQDTAAWENPMGTDGFEFIEYAAPDPQAMGRVFEGMGFKPVARHRHKNVTLYRQGEINFIINAEPDSFAQR
FARLHGPSVCAIAFRVHDAKAAYERALNLGAWGYAGQAGPGELNIPAIKGIGDSLIYLVDRWRGKNGAQPGDIGNIGFFD
VDFEPLPGVTAEEALNPKGHGLTYIDHLTHNVHRGRMIEWANFYERLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIP
INEEGKEKAGQIQEYLDMYNGEGIQHIAMGSDDLYATVDALRGSGVRLLDTIDTYYELVDKRIPGHGESVEELHKRKILI
DGKKDAILLQIFSENQLGPIFFEFIQRKGDDGFGNGNFKALFESIELDQMRRGVLQGA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=368, Percent_Identity=27.7173913043478, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI285002264, Length=359, Percent_Identity=27.8551532033426, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI14249394, Length=381, Percent_Identity=23.3595800524934, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555220, Length=307, Percent_Identity=31.9218241042345, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17550752, Length=204, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24667510, Length=372, Percent_Identity=31.4516129032258, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356105, Length=308, Percent_Identity=33.7662337662338, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 42200; Mature: 42200

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPLPHPAVQDTAAWENPMGTDGFEFIEYAAPDPQAMGRVFEGMGFKPVARHRHKNVTL
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCCCEEE
YRQGEINFIINAEPDSFAQRFARLHGPSVCAIAFRVHDAKAAYERALNLGAWGYAGQAGP
EEECCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHCCCCCCCCCCCCC
GELNIPAIKGIGDSLIYLVDRWRGKNGAQPGDIGNIGFFDVDFEPLPGVTAEEALNPKGH
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCC
GLTYIDHLTHNVHRGRMIEWANFYERLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIP
CCCHHHHHHHHHHCCCEEHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEC
INEEGKEKAGQIQEYLDMYNGEGIQHIAMGSDDLYATVDALRGSGVRLLDTIDTYYELVD
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHH
KRIPGHGESVEELHKRKILIDGKKDAILLQIFSENQLGPIFFEFIQRKGDDGFGNGNFKA
HCCCCCCHHHHHHHHCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHH
LFESIELDQMRRGVLQGA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTPLPHPAVQDTAAWENPMGTDGFEFIEYAAPDPQAMGRVFEGMGFKPVARHRHKNVTL
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCCCEEE
YRQGEINFIINAEPDSFAQRFARLHGPSVCAIAFRVHDAKAAYERALNLGAWGYAGQAGP
EEECCEEEEEECCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHCCCCCCCCCCCCC
GELNIPAIKGIGDSLIYLVDRWRGKNGAQPGDIGNIGFFDVDFEPLPGVTAEEALNPKGH
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHCCCCCC
GLTYIDHLTHNVHRGRMIEWANFYERLFNFREIRYFDIEGQVTGVKSKAMTSPCGKIRIP
CCCHHHHHHHHHHCCCEEHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEC
INEEGKEKAGQIQEYLDMYNGEGIQHIAMGSDDLYATVDALRGSGVRLLDTIDTYYELVD
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHH
KRIPGHGESVEELHKRKILIDGKKDAILLQIFSENQLGPIFFEFIQRKGDDGFGNGNFKA
HCCCCCCHHHHHHHHCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHH
LFESIELDQMRRGVLQGA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]