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The map label for this gene is glmU

Identifier: 120612676

GI number: 120612676

Start: 4490447

End: 4491871

Strand: Reverse

Name: glmU

Synonym: Aave_4039

Alternate gene names: 120612676

Gene position: 4491871-4490447 (Counterclockwise)

Preceding gene: 120612677

Following gene: 120612675

Centisome position: 83.92

GC content: 72.91

Gene sequence:

>1425_bases
ATGAGTGCACTGGACGTCATCATCATGGCCGCGGGCAAAGGCACGCGCATGAAAAGCCGCATTCCCAAGGTCCTGCAGCG
CCTGGCGGGGCGCCCGCTGCTGGGCCATGTGCTCGATCAGGCGCGCGGCCTGCAGGCCCGGCGTGCCGTGGTCGTGACGG
GCCATGGCGCGGCCGAGGTGGAGCCTTTCATCGCCCGCGCGGCGGACGGGCTGGACGTGCGCTGCGTGCGGCAGGAGCCG
CAGCTGGGCACCGGCCATGCCGTGCAGCAGGCGGTGCCGGCGCTGCAGGGCGACGGGACGGTGATCGTGCTGTCCGGCGA
CGTGCCGCTCACGCGCACGGACACCCTCCGCGCGCTGGTGGCGGCGGGCGGAGGCGGGCAACTGGCCCTGCTCACCGTGA
CCCTGCCGGACCCGGCGGGCTACGGGCGCATCGTGCGCGGCAGCGACGGCGCGGTGCGCGGCATCGTCGAGCACAAGGAC
GCCACCGAGGCGCAGCGCGCCATCGACGAGGTGTACAGCGGGATCATGGCCGTGCCCGCGGGGCTGCTGGCCGGCTGGCT
GGCGCGGCTGACCAACGACAACGCCCAGGGCGAGTACTACCTGACCGACATCGTGGCCATGGCCGTGGCCGACGGCGTGC
CCGTGGTGGCGCACCGCATCGCCGACGCGCTGCAGGTGGCCGGCGTGAACAGTCCGCTGCAACTGGCCGAGCTGGAGCGC
GCCCACCAGCTCGCACAGGCGCGCGCGCTGATGGAGCAGGGCGTGCGCCTGGCGGATCCCGCGCGCTTCGACCTGCGCGA
CGATGCGCGCACCGGCGTGCGCGGCGAACTGGCCTGCGGGCAGGATGTGGAAATCGACGTGAACTGCATCTTCTCCGGCC
GCGTGGAGCTGGGCGAGGGTGTGCGCATCGGCGCGCACTGCTGCATCGCCAACGCCCGCATCGCCGCGGGCGCGGTGGTC
CACCCCTACACCCACATCGACGGCGAGCAGCCGGCGGGCGTGCAGGTGGGCGAGGGGGCGCTGGTCGGACCGTTCGCGCG
GCTGCGGCCCGGCGCGCAGCTGGGGCGCGAGGTGCACATCGGCAACTTCGTGGAAGTGAAGAACTCGAGCCTGGCCGAGG
GCGCCAAGGCCAACCACCTCGCCTACCTGGGCGACGCCACGGTGGGCGAGCGCGTGAACTATGGCGCCGGCAGCATCACC
GCCAACTACGACGGCGCGAACAAGCACCGCACGGTGATCGAGGCCGACGTGCACGTCGGCAGCAACTGCGTGCTGGTGGC
GCCCGTGACCATCGGTGCGGGCGGCACGGTGGGCGGTGGCTCCACCATCACCAAGAGCACGCCCGCGGGCGCCCTGAGCG
TGGCCCGCGGCAAGCAGGTCACCAAAGAAAACTGGCAGCGGCCGGCCAAGCTGCCCAAGGCATGA

Upstream 100 bases:

>100_bases
GGCCCTGCCAGCAGCGGCGGCGGATAATCGGCCATTCCGGCCCGATGGCCGGTGGCGTGCCGTTCCGATCTTTCCTTCCC
CCATTTCCCTTCCTATTTCC

Downstream 100 bases:

>100_bases
CGGAAGAACGTGCCGGCGCCGCCTGTCCGTCCGGGCCGGGGCCATCCCCGTACGAGGGCCTGGATGCGCCCGCGCTGCGT
GCTTTGCTGGCCGAGCGCGA

Product: UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSALDVIIMAAGKGTRMKSRIPKVLQRLAGRPLLGHVLDQARGLQARRAVVVTGHGAAEVEPFIARAADGLDVRCVRQEP
QLGTGHAVQQAVPALQGDGTVIVLSGDVPLTRTDTLRALVAAGGGGQLALLTVTLPDPAGYGRIVRGSDGAVRGIVEHKD
ATEAQRAIDEVYSGIMAVPAGLLAGWLARLTNDNAQGEYYLTDIVAMAVADGVPVVAHRIADALQVAGVNSPLQLAELER
AHQLAQARALMEQGVRLADPARFDLRDDARTGVRGELACGQDVEIDVNCIFSGRVELGEGVRIGAHCCIANARIAAGAVV
HPYTHIDGEQPAGVQVGEGALVGPFARLRPGAQLGREVHIGNFVEVKNSSLAEGAKANHLAYLGDATVGERVNYGAGSIT
ANYDGANKHRTVIEADVHVGSNCVLVAPVTIGAGGTVGGGSTITKSTPAGALSVARGKQVTKENWQRPAKLPKA

Sequences:

>Translated_474_residues
MSALDVIIMAAGKGTRMKSRIPKVLQRLAGRPLLGHVLDQARGLQARRAVVVTGHGAAEVEPFIARAADGLDVRCVRQEP
QLGTGHAVQQAVPALQGDGTVIVLSGDVPLTRTDTLRALVAAGGGGQLALLTVTLPDPAGYGRIVRGSDGAVRGIVEHKD
ATEAQRAIDEVYSGIMAVPAGLLAGWLARLTNDNAQGEYYLTDIVAMAVADGVPVVAHRIADALQVAGVNSPLQLAELER
AHQLAQARALMEQGVRLADPARFDLRDDARTGVRGELACGQDVEIDVNCIFSGRVELGEGVRIGAHCCIANARIAAGAVV
HPYTHIDGEQPAGVQVGEGALVGPFARLRPGAQLGREVHIGNFVEVKNSSLAEGAKANHLAYLGDATVGERVNYGAGSIT
ANYDGANKHRTVIEADVHVGSNCVLVAPVTIGAGGTVGGGSTITKSTPAGALSVARGKQVTKENWQRPAKLPKA
>Mature_473_residues
SALDVIIMAAGKGTRMKSRIPKVLQRLAGRPLLGHVLDQARGLQARRAVVVTGHGAAEVEPFIARAADGLDVRCVRQEPQ
LGTGHAVQQAVPALQGDGTVIVLSGDVPLTRTDTLRALVAAGGGGQLALLTVTLPDPAGYGRIVRGSDGAVRGIVEHKDA
TEAQRAIDEVYSGIMAVPAGLLAGWLARLTNDNAQGEYYLTDIVAMAVADGVPVVAHRIADALQVAGVNSPLQLAELERA
HQLAQARALMEQGVRLADPARFDLRDDARTGVRGELACGQDVEIDVNCIFSGRVELGEGVRIGAHCCIANARIAAGAVVH
PYTHIDGEQPAGVQVGEGALVGPFARLRPGAQLGREVHIGNFVEVKNSSLAEGAKANHLAYLGDATVGERVNYGAGSITA
NYDGANKHRTVIEADVHVGSNCVLVAPVTIGAGGTVGGGSTITKSTPAGALSVARGKQVTKENWQRPAKLPKA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=469, Percent_Identity=48.8272921108742, Blast_Score=423, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_ACIAC (A1TUE2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972354.1
- ProteinModelPortal:   A1TUE2
- SMR:   A1TUE2
- STRING:   A1TUE2
- GeneID:   4666108
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4039
- NMPDR:   fig|397945.5.peg.3458
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A1TUE2
- ProtClustDB:   CLSK951126
- BioCyc:   AAVE397945:AAVE_4039-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49099; Mature: 48967

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 379-379 BINDING 78-78 BINDING 142-142 BINDING 157-157 BINDING 403-403 BINDING 421-421 BINDING 439-439 BINDING 456-456

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALDVIIMAAGKGTRMKSRIPKVLQRLAGRPLLGHVLDQARGLQARRAVVVTGHGAAEV
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHC
EPFIARAADGLDVRCVRQEPQLGTGHAVQQAVPALQGDGTVIVLSGDVPLTRTDTLRALV
CHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHE
AAGGGGQLALLTVTLPDPAGYGRIVRGSDGAVRGIVEHKDATEAQRAIDEVYSGIMAVPA
ECCCCCEEEEEEEECCCCCCCCEEEECCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHH
GLLAGWLARLTNDNAQGEYYLTDIVAMAVADGVPVVAHRIADALQVAGVNSPLQLAELER
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
AHQLAQARALMEQGVRLADPARFDLRDDARTGVRGELACGQDVEIDVNCIFSGRVELGEG
HHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEECCCC
VRIGAHCCIANARIAAGAVVHPYTHIDGEQPAGVQVGEGALVGPFARLRPGAQLGREVHI
EEECCEEEEECCEECCCEEECCEECCCCCCCCCCEECCCCEECCHHHCCCCHHHCCEEEC
GNFVEVKNSSLAEGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTVIEADVHVG
CCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEC
SNCVLVAPVTIGAGGTVGGGSTITKSTPAGALSVARGKQVTKENWQRPAKLPKA
CCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEHHCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SALDVIIMAAGKGTRMKSRIPKVLQRLAGRPLLGHVLDQARGLQARRAVVVTGHGAAEV
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCCHHC
EPFIARAADGLDVRCVRQEPQLGTGHAVQQAVPALQGDGTVIVLSGDVPLTRTDTLRALV
CHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHE
AAGGGGQLALLTVTLPDPAGYGRIVRGSDGAVRGIVEHKDATEAQRAIDEVYSGIMAVPA
ECCCCCEEEEEEEECCCCCCCCEEEECCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHH
GLLAGWLARLTNDNAQGEYYLTDIVAMAVADGVPVVAHRIADALQVAGVNSPLQLAELER
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
AHQLAQARALMEQGVRLADPARFDLRDDARTGVRGELACGQDVEIDVNCIFSGRVELGEG
HHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEECCCC
VRIGAHCCIANARIAAGAVVHPYTHIDGEQPAGVQVGEGALVGPFARLRPGAQLGREVHI
EEECCEEEEECCEECCCEEECCEECCCCCCCCCCEECCCCEECCHHHCCCCHHHCCEEEC
GNFVEVKNSSLAEGAKANHLAYLGDATVGERVNYGAGSITANYDGANKHRTVIEADVHVG
CCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEC
SNCVLVAPVTIGAGGTVGGGSTITKSTPAGALSVARGKQVTKENWQRPAKLPKA
CCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEHHCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA