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The map label for this gene is aadR [H]

Identifier: 120612677

GI number: 120612677

Start: 4491992

End: 4492762

Strand: Reverse

Name: aadR [H]

Synonym: Aave_4040

Alternate gene names: 120612677

Gene position: 4492762-4491992 (Counterclockwise)

Preceding gene: 120612679

Following gene: 120612676

Centisome position: 83.93

GC content: 67.96

Gene sequence:

>771_bases
ATGAGTACCGATGTCGTTTCCGCTGGGCCCCTCCTGGAGGTCCCGCGCCATTGCGGTGCCTGCCGGCTCCGCCAGCGCAC
CCAGGCCTTCACTCCGGCGACGGGCGAAGAATTGTCCTTCATCGAGTCCTACCGCTGCGGCGTGGAAATGGTGAGGGCGG
GCGGCACCCTGATCCGCGAGCGCCAGTCCGGCGGCCGGCTCTATACGCTCTACAGCGGCTGGGCCTTCCGCTACAAGACG
CTGTCGGACGGGCGCCGGCAGATCCTGAATTTCCTGCTTCCGGGCGACCTGGTGGGATTGCAGCAGGAGTTTTCCGACGC
CGCCCTGCACGGCGTGGAAGCCGTGACGGACTGCGCCTTCTGCGCGTTCGATGCCGATGGCCTGTGGTCGATGTTCCGCG
AACATGCGCGGCTGGCCTACGGGGTCACCTGGCTGGCGGCCCGGGGCGAAGGCATGGTGGACGACAACCTGCTCACGGCC
GGCCGGCGCTCCGCGATCGAGCGGGTGGCCGTGCTGCTGGTGCACCTGTATCGCCGCCTGGACCGGCTGGGGCTGGCGGA
GGGTGGATCGGTGGATTTCCCGATCAACCAGCAGCACATCGCTGATGCGCTGGGGTTGTCGCTGGTGCACACCAACAAGA
CGCTGCGGCGCCTGTCCGAGATGGGGATGCATGAAATCTCGGGGGGGCGCCTGCGGCTGCTCAATCCACGGGCGCTGGCG
CGCATCGGGGAATACTACGACGTCATTCCCCGGCCCGTGCCCCTGCTGTGA

Upstream 100 bases:

>100_bases
GCAATGTCAAAAGACATAGCCTGCGGGAACACCGATTGCCTAGAATCGCCGCCGCGCTATTGTTGCGCTCCCTTCCATTT
TCTCCGCAAGCGCTGGCCGT

Downstream 100 bases:

>100_bases
CCGCCGGGGGGCGGGCTGGCGGCCCTGCCAGCAGCGGCGGCGGATAATCGGCCATTCCGGCCCGATGGCCGGTGGCGTGC
CGTTCCGATCTTTCCTTCCC

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: Anaerobic aromatic degradation regulator [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSTDVVSAGPLLEVPRHCGACRLRQRTQAFTPATGEELSFIESYRCGVEMVRAGGTLIRERQSGGRLYTLYSGWAFRYKT
LSDGRRQILNFLLPGDLVGLQQEFSDAALHGVEAVTDCAFCAFDADGLWSMFREHARLAYGVTWLAARGEGMVDDNLLTA
GRRSAIERVAVLLVHLYRRLDRLGLAEGGSVDFPINQQHIADALGLSLVHTNKTLRRLSEMGMHEISGGRLRLLNPRALA
RIGEYYDVIPRPVPLL

Sequences:

>Translated_256_residues
MSTDVVSAGPLLEVPRHCGACRLRQRTQAFTPATGEELSFIESYRCGVEMVRAGGTLIRERQSGGRLYTLYSGWAFRYKT
LSDGRRQILNFLLPGDLVGLQQEFSDAALHGVEAVTDCAFCAFDADGLWSMFREHARLAYGVTWLAARGEGMVDDNLLTA
GRRSAIERVAVLLVHLYRRLDRLGLAEGGSVDFPINQQHIADALGLSLVHTNKTLRRLSEMGMHEISGGRLRLLNPRALA
RIGEYYDVIPRPVPLL
>Mature_255_residues
STDVVSAGPLLEVPRHCGACRLRQRTQAFTPATGEELSFIESYRCGVEMVRAGGTLIRERQSGGRLYTLYSGWAFRYKTL
SDGRRQILNFLLPGDLVGLQQEFSDAALHGVEAVTDCAFCAFDADGLWSMFREHARLAYGVTWLAARGEGMVDDNLLTAG
RRSAIERVAVLLVHLYRRLDRLGLAEGGSVDFPINQQHIADALGLSLVHTNKTLRRLSEMGMHEISGGRLRLLNPRALAR
IGEYYDVIPRPVPLL

Specific function: Transcriptional activator of anaerobic gene expression. For aromatic acid degradation. Also required for the anaerobic degradation of benzoate [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 28401; Mature: 28270

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDVVSAGPLLEVPRHCGACRLRQRTQAFTPATGEELSFIESYRCGVEMVRAGGTLIRE
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEH
RQSGGRLYTLYSGWAFRYKTLSDGRRQILNFLLPGDLVGLQQEFSDAALHGVEAVTDCAF
HCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
CAFDADGLWSMFREHARLAYGVTWLAARGEGMVDDNLLTAGRRSAIERVAVLLVHLYRRL
HHCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DRLGLAEGGSVDFPINQQHIADALGLSLVHTNKTLRRLSEMGMHEISGGRLRLLNPRALA
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEECHHHHH
RIGEYYDVIPRPVPLL
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STDVVSAGPLLEVPRHCGACRLRQRTQAFTPATGEELSFIESYRCGVEMVRAGGTLIRE
CCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEH
RQSGGRLYTLYSGWAFRYKTLSDGRRQILNFLLPGDLVGLQQEFSDAALHGVEAVTDCAF
HCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
CAFDADGLWSMFREHARLAYGVTWLAARGEGMVDDNLLTAGRRSAIERVAVLLVHLYRRL
HHCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DRLGLAEGGSVDFPINQQHIADALGLSLVHTNKTLRRLSEMGMHEISGGRLRLLNPRALA
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEECHHHHH
RIGEYYDVIPRPVPLL
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1522059; 10094687 [H]