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The map label for this gene is glmS [H]

Identifier: 120612673

GI number: 120612673

Start: 4487005

End: 4488894

Strand: Reverse

Name: glmS [H]

Synonym: Aave_4036

Alternate gene names: 120612673

Gene position: 4488894-4487005 (Counterclockwise)

Preceding gene: 120612675

Following gene: 120612671

Centisome position: 83.86

GC content: 70.26

Gene sequence:

>1890_bases
ATGTGCGGCATCGTCGGCGCAGTCTCCACGCGCAACATCGTTCCCATCCTCGTGCAAGGCCTGCAGCGGCTGGAATACCG
GGGCTACGACTCCTGCGGCGTGGCGATCCATGACGCCAGCCTGGGCGCCACGCCCACCGGCGGCCTGCGCCGCGCCCGCA
GCACGGCGCGCGTGGCGGAACTGCTGGAGCAGGTGCGCACCGAGCATGTCGAAGGCGCCACCGGCATCGCCCACACGCGC
TGGGCCACGCACGGCGCACCGGCCGTGCACAACGCGCATCCGCACTTCAGCCACGGCTCCGGCCCGGACGAGCCGCTGCG
CCTGGGCCGCGTCGCGCTGGTGCACAACGGCATCATCGAGAACCACGAGGCGCTGCGCGCATCGCTGCAGGCCCGCGGCT
ACGTGTTCACCAGCCAGACGGACACCGAGGTCATCGCCCACCTCGTGGACAGCCACTACAGCGGCGACCTGTTCCAGGCC
GTGCGCGCCGCCGTGGCCGAACTGCATGGCGCCTATGCCATCGCCGTGATCCACAAGGACGAGCCCCACCGCGTGGTGGG
CGCCCGCGCCGGCTCCCCGCTGATCCTCGGCGTGGGCGAAGGCGAGCACTTCCTGGCGAGCGACGCCATGGCCCTGGCCG
GCGTCACCGACCAGATCGTCTATCTGGAAGAGGGCGACCTCGTCGATCTGCAGCTGGGCCGCTACTGGATCGCCGGCAAG
GACGGCCAGCCCCTGGATGCCGCGAGCCGCCCCGTGCGCACCGTGCTGGCCCACAGCGGCGCGGCCGAACTGGGCCCGTA
CCGCCACTACATGCAGAAGGAGATCTTCGAGCAGCCGCGCGCCATCGGCGACACGCTGGAAGGCGTGCGCGGCGTGGCGC
CCGAGCTGTTCGACGGCGCCGACGGCACCGCCGCCTGGCGCGTGTTCAAGGAAGTGGATTCCGTCCTGATCCTGGCCTGC
GGCACCAGCTACTACAGCGGCTGCACGGCCAAGTACTGGCTCGAGTCCATCGCCGGCATTCCCACGCAGGTGGAGGTGGC
GAGCGAGTACCGCTACCGCACCAGCGTGCCCAACCCGCGCGCGCTGGTGGTGACCATCAGCCAGTCCGGCGAGACCGCCG
ACACCCTGGCCGCGCTGCGCCATGCACAGGGCCTGGGCATGCAGCACACGCTGACCATCTGCAACGTCTCCACCAGCGCC
ATGGTGCGCGAATGCAAGCTGGCCTACATCACCCGCGCGGGCGTGGAGATCGGCGTGGCTTCCACCAAGGCCTTCACCAC
CCAGCTCGCGGGCCTGTTCCTGCTCACGCTGGCGCTGGCGCAGGCGCGCGGCCGCCTGAGCGAAGAGCAGGAGGCGCGCC
ACCTGCAGGCCATGCGCCACCTGCCCGTGGCCCTGCAGGGCGTGCTCGCGCTCGAGCCGCAGATCATCAGCTGGGCCGAG
GACTTCGCGAAGATGGAGAACGCCCTGTTCCTGGGCCGCGGCGTGCACTACCCCATCGCCCTGGAAGGCGCGCTCAAGCT
CAAGGAGATCAGCTACATCCACGCCGAGGCCTACCCGGCCGGCGAGCTCAAGCACGGCCCCCTGGCCCTGGTGACCAGCA
GCATGCCCGTGGTCACCGTGGCGCCCAACGACGAACTGCTGGAAAAGCTCAAGAGCAACCTGCAGGAAGTGCGCGCCCGC
GGCGGCGTGCTCTACGTGCTGGCCGACGCCAAGACCAACATCGACACGTCCGATGGCATGCACGTGATCCGCATGCCCGA
GAACTACGGCGCGCTCAGCCCGATCCTGCACGTGGTGCCGCTGCAGCTGCTGGCGTACCACACGGCGTGCGCGCGCGGGA
CGGACGTGGACAAGCCGCGGAATCTGGCGAAGAGCGTGACGGTGGAGTGA

Upstream 100 bases:

>100_bases
TCGAGCTGAAATTTTATGCGGTCGTGCCTACGATGGCAGCCGCTCACGCCCAGTCCCCCCTTTCCATCGTTCCTGAACTC
TTCCCTGAAGGACCCCCTCC

Downstream 100 bases:

>100_bases
GGGGGCTTACGCCGCTTCTTGGGCGGCTTGCACACCCAGCAACTTCTCCAGCGCCTCCACCCGGTGCCGCCGCGGCACCG
TGATGGCGTAGAAGCTCTCG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAIHDASLGATPTGGLRRARSTARVAELLEQVRTEHVEGATGIAHTR
WATHGAPAVHNAHPHFSHGSGPDEPLRLGRVALVHNGIIENHEALRASLQARGYVFTSQTDTEVIAHLVDSHYSGDLFQA
VRAAVAELHGAYAIAVIHKDEPHRVVGARAGSPLILGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIAGK
DGQPLDAASRPVRTVLAHSGAAELGPYRHYMQKEIFEQPRAIGDTLEGVRGVAPELFDGADGTAAWRVFKEVDSVLILAC
GTSYYSGCTAKYWLESIAGIPTQVEVASEYRYRTSVPNPRALVVTISQSGETADTLAALRHAQGLGMQHTLTICNVSTSA
MVRECKLAYITRAGVEIGVASTKAFTTQLAGLFLLTLALAQARGRLSEEQEARHLQAMRHLPVALQGVLALEPQIISWAE
DFAKMENALFLGRGVHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPNDELLEKLKSNLQEVRAR
GGVLYVLADAKTNIDTSDGMHVIRMPENYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_629_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAIHDASLGATPTGGLRRARSTARVAELLEQVRTEHVEGATGIAHTR
WATHGAPAVHNAHPHFSHGSGPDEPLRLGRVALVHNGIIENHEALRASLQARGYVFTSQTDTEVIAHLVDSHYSGDLFQA
VRAAVAELHGAYAIAVIHKDEPHRVVGARAGSPLILGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIAGK
DGQPLDAASRPVRTVLAHSGAAELGPYRHYMQKEIFEQPRAIGDTLEGVRGVAPELFDGADGTAAWRVFKEVDSVLILAC
GTSYYSGCTAKYWLESIAGIPTQVEVASEYRYRTSVPNPRALVVTISQSGETADTLAALRHAQGLGMQHTLTICNVSTSA
MVRECKLAYITRAGVEIGVASTKAFTTQLAGLFLLTLALAQARGRLSEEQEARHLQAMRHLPVALQGVLALEPQIISWAE
DFAKMENALFLGRGVHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPNDELLEKLKSNLQEVRAR
GGVLYVLADAKTNIDTSDGMHVIRMPENYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE
>Mature_629_residues
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAIHDASLGATPTGGLRRARSTARVAELLEQVRTEHVEGATGIAHTR
WATHGAPAVHNAHPHFSHGSGPDEPLRLGRVALVHNGIIENHEALRASLQARGYVFTSQTDTEVIAHLVDSHYSGDLFQA
VRAAVAELHGAYAIAVIHKDEPHRVVGARAGSPLILGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIAGK
DGQPLDAASRPVRTVLAHSGAAELGPYRHYMQKEIFEQPRAIGDTLEGVRGVAPELFDGADGTAAWRVFKEVDSVLILAC
GTSYYSGCTAKYWLESIAGIPTQVEVASEYRYRTSVPNPRALVVTISQSGETADTLAALRHAQGLGMQHTLTICNVSTSA
MVRECKLAYITRAGVEIGVASTKAFTTQLAGLFLLTLALAQARGRLSEEQEARHLQAMRHLPVALQGVLALEPQIISWAE
DFAKMENALFLGRGVHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTVAPNDELLEKLKSNLQEVRAR
GGVLYVLADAKTNIDTSDGMHVIRMPENYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=692, Percent_Identity=34.6820809248555, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI4826742, Length=693, Percent_Identity=34.7763347763348, Blast_Score=373, Evalue=1e-103,
Organism=Escherichia coli, GI1790167, Length=632, Percent_Identity=52.373417721519, Blast_Score=615, Evalue=1e-177,
Organism=Escherichia coli, GI1788651, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=724, Percent_Identity=34.1160220994475, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17532899, Length=725, Percent_Identity=32.9655172413793, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17532897, Length=445, Percent_Identity=36.8539325842697, Blast_Score=267, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=35.7798165137615, Blast_Score=253, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=29.7921478060046, Blast_Score=187, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6323730, Length=218, Percent_Identity=36.697247706422, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=35.014409221902, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI28573187, Length=212, Percent_Identity=25.9433962264151, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24659598, Length=209, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24659604, Length=189, Percent_Identity=26.984126984127, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67630; Mature: 67630

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAIHDASLGATPTGGLRRARSTARVAE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
LLEQVRTEHVEGATGIAHTRWATHGAPAVHNAHPHFSHGSGPDEPLRLGRVALVHNGIIE
HHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEECCCCHH
NHEALRASLQARGYVFTSQTDTEVIAHLVDSHYSGDLFQAVRAAVAELHGAYAIAVIHKD
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECC
EPHRVVGARAGSPLILGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIAGK
CCCEEEECCCCCCEEEEECCCCCCHHHCHHHHCCCCCEEEEEECCCEEEEEECCEEEECC
DGQPLDAASRPVRTVLAHSGAAELGPYRHYMQKEIFEQPRAIGDTLEGVRGVAPELFDGA
CCCCCCHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHCCC
DGTAAWRVFKEVDSVLILACGTSYYSGCTAKYWLESIAGIPTQVEVASEYRYRTSVPNPR
CCHHHHHHHHHHCCEEEEEECCHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCC
ALVVTISQSGETADTLAALRHAQGLGMQHTLTICNVSTSAMVRECKLAYITRAGVEIGVA
EEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHEECCCCEEECC
STKAFTTQLAGLFLLTLALAQARGRLSEEQEARHLQAMRHLPVALQGVLALEPQIISWAE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHH
DFAKMENALFLGRGVHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTV
HHHHHHHHEEEECCCCCCEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEE
APNDELLEKLKSNLQEVRARGGVLYVLADAKTNIDTSDGMHVIRMPENYGALSPILHVVP
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
LQLLAYHTACARGTDVDKPRNLAKSVTVE
HHHHHHHHHHCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSTRNIVPILVQGLQRLEYRGYDSCGVAIHDASLGATPTGGLRRARSTARVAE
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
LLEQVRTEHVEGATGIAHTRWATHGAPAVHNAHPHFSHGSGPDEPLRLGRVALVHNGIIE
HHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEECCCCHH
NHEALRASLQARGYVFTSQTDTEVIAHLVDSHYSGDLFQAVRAAVAELHGAYAIAVIHKD
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEECC
EPHRVVGARAGSPLILGVGEGEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWIAGK
CCCEEEECCCCCCEEEEECCCCCCHHHCHHHHCCCCCEEEEEECCCEEEEEECCEEEECC
DGQPLDAASRPVRTVLAHSGAAELGPYRHYMQKEIFEQPRAIGDTLEGVRGVAPELFDGA
CCCCCCHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHCCC
DGTAAWRVFKEVDSVLILACGTSYYSGCTAKYWLESIAGIPTQVEVASEYRYRTSVPNPR
CCHHHHHHHHHHCCEEEEEECCHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCC
ALVVTISQSGETADTLAALRHAQGLGMQHTLTICNVSTSAMVRECKLAYITRAGVEIGVA
EEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHEECCCCEEECC
STKAFTTQLAGLFLLTLALAQARGRLSEEQEARHLQAMRHLPVALQGVLALEPQIISWAE
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHH
DFAKMENALFLGRGVHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTSSMPVVTV
HHHHHHHHEEEECCCCCCEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEE
APNDELLEKLKSNLQEVRARGGVLYVLADAKTNIDTSDGMHVIRMPENYGALSPILHVVP
CCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHH
LQLLAYHTACARGTDVDKPRNLAKSVTVE
HHHHHHHHHHCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]