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The map label for this gene is nuoL [H]

Identifier: 120612671

GI number: 120612671

Start: 4484520

End: 4486049

Strand: Reverse

Name: nuoL [H]

Synonym: Aave_4034

Alternate gene names: 120612671

Gene position: 4486049-4484520 (Counterclockwise)

Preceding gene: 120612673

Following gene: 120612670

Centisome position: 83.81

GC content: 74.9

Gene sequence:

>1530_bases
ATGTGCGGCTCGCCACCATGGCGACCCATGCAAGACCTCGACTTTCTTCTCTCCATTGCTGCCCTGTTGCCCGCGGCGCT
GATGCTGTGCGCCGCGGCCGGGCTGTCGCTTCACCGGGGTGCGGTGCGCCCTGCCTGGCGGGCGCTGCACGCGGCATCTG
CGCTCGGCCTGATGGCCGCGCTGGCCGCGCTGGTCGCCGTGGCCACCGGTGCGTCCGCACCGCTCGCTCCCTGGCTGCGC
CCGACGCTGCCGGGCACCGCCGTGGCGGTGCTCGTGCAGGCGCTGGGCGGGGTGGTGGGCGTGTTCTCGACCCGCTACCT
GGACGGCGAGCCGCGCCAGGCCCGCTACGCCGCCGCGCTGGCCGCGGTATTGGGCGGCGTGCAGGTGCTGCTGCTGGCCG
ACCACTGGGCCGTGCTGATCGCCGCCTGGGCCGGCATCGGCCTGGCGCTGGAGCGGCTGCTGTGCTTCTATGCCGACCGC
CCGTTCGCGCTGCTGGCCGCGCACAAGAAGCGCGTGGCCGACCGCGCGGCCGATGGGCTGCTGGTCGCTGCCGCGGCGCT
GAGCTGGCATGCGGTGGGCAGCGGCTCGCTGAGCGACCTGGCGGCCCATGTGCAGGCCGCGGGCCTGTCGGCGCCGCTGC
AGGTGGCGGCCGTGCTGCTGGTGGCCGCCGTCGTGTTGCGCACCGCGCTGATGCCGGTGCACGGCTGGCTGATCCAGGTG
ATGGAGGCGCCCACGCCGGTGTCGGCGCTGCTGCATGCCGGTGTCGTGAACCTGGGGGGCGTGGTGCTGATCCGCTGCGC
GCCGCTGCTGGAACACGCCATGCCGGCGCGCGCCATCCTCGTCGCGCTGGGCCTGCTGACGGCGCTGGGCGCCGGCCTGG
TGATGCTGACCCGCATCAGCATCAAGGTGCGGCTGGCCTGGAGCACCGTGGCGCAGATGGGCTTCATGCTGGTGGAATGC
GGCCTGGGTCTCTACACCCTCGCGGCGCTGCACCTGCTGGGCCATTCCATTTACAAGGCGCATGCCTTCCTGGCCGCGTC
CGACGTGGTGCGGCAGACCCGGGCGCGTGCGCTGCGGCCGCCGCAGTTGCCGGCCCGCGCCAGCCTGCTCGCCGCGCCGC
TGCTGGCCGGGGCGGTCGTGGCGGCTGTGGGCGGCGGCTGGCCGCTGTGGTGGACGGGTGTGATGGCGCTGGCCTGGGCA
CCGCTGCTGTGGGCATCGACGCTGCGGCAGCTGGTCGCCGGGCTGGCCGCCACGGCGCTGCTGACGGCCGTGGCCCGCGC
CGCCCACGCGCTGCCGCTGGGCCTGCACGACGCGCCGCATGACGCGCTGGGCTTCCTGGCCCTGGCCGGCATGGCCGCGC
TCTACGCCGTGCTCGTCGCGCTGCAGATGCGCCCGCAGGCACTGCTCACCGCGCGCCGCTGGAGCTACGCCGGCTTCTAC
CTCGACGAGTTCTATACCCGCTGGAGCCTGCGCCTGTGGCCGCGCCGCTGGACGCCCACGCCGCCCCCACCGCGCCCCGC
CACGATCTGA

Upstream 100 bases:

>100_bases
CACCCGCCAGAAGTAGAAGAGGTGATGAAAGTTGAGCTGCTCGAGGCGCATTGTTCTGTTTAAAAGATCAATCTGTTTCC
TTTAATGAATTTTACAGAAC

Downstream 100 bases:

>100_bases
CAGAGAAAGAAGAAAACCATGCACACCGACACCCTCGAACACGACGCCCTGGCCCGGGCCGGGGCGCACGCCCGCATCCA
GGCTGCCTGCGCCCAGGCCT

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MCGSPPWRPMQDLDFLLSIAALLPAALMLCAAAGLSLHRGAVRPAWRALHAASALGLMAALAALVAVATGASAPLAPWLR
PTLPGTAVAVLVQALGGVVGVFSTRYLDGEPRQARYAAALAAVLGGVQVLLLADHWAVLIAAWAGIGLALERLLCFYADR
PFALLAAHKKRVADRAADGLLVAAAALSWHAVGSGSLSDLAAHVQAAGLSAPLQVAAVLLVAAVVLRTALMPVHGWLIQV
MEAPTPVSALLHAGVVNLGGVVLIRCAPLLEHAMPARAILVALGLLTALGAGLVMLTRISIKVRLAWSTVAQMGFMLVEC
GLGLYTLAALHLLGHSIYKAHAFLAASDVVRQTRARALRPPQLPARASLLAAPLLAGAVVAAVGGGWPLWWTGVMALAWA
PLLWASTLRQLVAGLAATALLTAVARAAHALPLGLHDAPHDALGFLALAGMAALYAVLVALQMRPQALLTARRWSYAGFY
LDEFYTRWSLRLWPRRWTPTPPPPRPATI

Sequences:

>Translated_509_residues
MCGSPPWRPMQDLDFLLSIAALLPAALMLCAAAGLSLHRGAVRPAWRALHAASALGLMAALAALVAVATGASAPLAPWLR
PTLPGTAVAVLVQALGGVVGVFSTRYLDGEPRQARYAAALAAVLGGVQVLLLADHWAVLIAAWAGIGLALERLLCFYADR
PFALLAAHKKRVADRAADGLLVAAAALSWHAVGSGSLSDLAAHVQAAGLSAPLQVAAVLLVAAVVLRTALMPVHGWLIQV
MEAPTPVSALLHAGVVNLGGVVLIRCAPLLEHAMPARAILVALGLLTALGAGLVMLTRISIKVRLAWSTVAQMGFMLVEC
GLGLYTLAALHLLGHSIYKAHAFLAASDVVRQTRARALRPPQLPARASLLAAPLLAGAVVAAVGGGWPLWWTGVMALAWA
PLLWASTLRQLVAGLAATALLTAVARAAHALPLGLHDAPHDALGFLALAGMAALYAVLVALQMRPQALLTARRWSYAGFY
LDEFYTRWSLRLWPRRWTPTPPPPRPATI
>Mature_509_residues
MCGSPPWRPMQDLDFLLSIAALLPAALMLCAAAGLSLHRGAVRPAWRALHAASALGLMAALAALVAVATGASAPLAPWLR
PTLPGTAVAVLVQALGGVVGVFSTRYLDGEPRQARYAAALAAVLGGVQVLLLADHWAVLIAAWAGIGLALERLLCFYADR
PFALLAAHKKRVADRAADGLLVAAAALSWHAVGSGSLSDLAAHVQAAGLSAPLQVAAVLLVAAVVLRTALMPVHGWLIQV
MEAPTPVSALLHAGVVNLGGVVLIRCAPLLEHAMPARAILVALGLLTALGAGLVMLTRISIKVRLAWSTVAQMGFMLVEC
GLGLYTLAALHLLGHSIYKAHAFLAASDVVRQTRARALRPPQLPARASLLAAPLLAGAVVAAVGGGWPLWWTGVMALAWA
PLLWASTLRQLVAGLAATALLTAVARAAHALPLGLHDAPHDALGFLALAGMAALYAVLVALQMRPQALLTARRWSYAGFY
LDEFYTRWSLRLWPRRWTPTPPPPRPATI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=258, Percent_Identity=30.6201550387597, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1788614, Length=336, Percent_Identity=30.0595238095238, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788831, Length=153, Percent_Identity=37.2549019607843, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=285, Percent_Identity=27.719298245614, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53100; Mature: 53100

Theoretical pI: Translated: 11.09; Mature: 11.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]