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The map label for this gene is gpsA

Identifier: 120612495

GI number: 120612495

Start: 4281771

End: 4282799

Strand: Reverse

Name: gpsA

Synonym: Aave_3854

Alternate gene names: 120612495

Gene position: 4282799-4281771 (Counterclockwise)

Preceding gene: 120612496

Following gene: 120612492

Centisome position: 80.01

GC content: 72.79

Gene sequence:

>1029_bases
ATGAAGATCATCGTGTTCGGTGCCGGCGCCTGGGGCACGGCCATGGCCCTCAGCGCGGCCGCGCACCCGGCCGGACATGC
CGTGACCCTCTGGGCGCGCGACGGGCGCCAGGCCGACGCCATGCAGGCGGCCCGCCAGAACGCCCGCTATCTTCCAGGCA
TCGCCTTTCCTGCCGCCCTGGCCCTCGCGAGCGGTGCGCCTTCCGGGGCGCTCGCGTCCTGCCGGGCCGATCTGGCCATC
GTCGCGACCCCCATGTCCGGCCTGCGCGGCATGCTGGAGGAACTGCGCGATGCGACCATTCCCGTGGCCTGGCTCTGCAA
GGGGTTCGAAGCCGTTCCCGCAGGCGGCGAGACCGCTGCCCAGGGCCTGATGGCGCACGAGATCTGCAGCCAGGTGGCCC
CGCGGTTGCGCGCGGGCGCGCTCAGCGGCCCGAGCTTCGCGCTGGAGGCGGCGCAGGGGCGGCCCACCGCGCTGGTGGCC
GCCAGCCGCGATGCGCACGTGCGTGAACTGCTCGTGGAAGCGTTCCATGGGCCCACGCTGCGCGTTTACGCCAACGAGGA
CATCGTGGGCGTGGAAGTGGGGGGCGCCGTGAAGAATGTGCTGGCCATCGCCACCGGGCTGTGCGACGGTCTGGACCTGG
GCACGAACGCGCGTGCCGCGCTCATTACCCGGGGTTTGGCCGAGATGAGCCGGCTCGGGCTCGCGCTCGGCGCGCGGGCG
GAGACGTTCATGGGGCTTTCGGGGCTGGGCGACCTGGTGCTGACGGCCACCGGAGACCTGTCGCGCAACCGCCGCGTGGG
CCTGGCGCTCGCGCGCGGGCTCACACTGGATCAGGCGGTGGAATCGCTCGGCCATGTGGCCGAAGGGGTGTACAGCGCAC
GGACGGTGGTGCGGCGTGCGGGCCAGCTCGGCGTGGACATGCCGATCGCACGAGAGGTGGTGGCACTGCTGGATGGCCGG
TCAACCGCTTCCGACGCGGTGGCGCGGCTGATGGGGCGCAGTCCCGCGGCCGAGTTGCGCTCCTGCTGA

Upstream 100 bases:

>100_bases
GTCACGCAGTAATTCTTCCCACCGGGCGCCGCCGCGCGGCGGCGCATCGCAGCCGGGGACTGCGAGCGGTTCCCCTGCCG
AAACCGCAACGACATCCCCC

Downstream 100 bases:

>100_bases
ACGCTGCCCGTCCGCGATGCGCCGGCGTGGGTGCCGGAATGCCGGCAGCCCGCGCCATGGATGCGCATCACACGACGCCG
AAGAGCATCAGCAGCAGGAC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKIIVFGAGAWGTAMALSAAAHPAGHAVTLWARDGRQADAMQAARQNARYLPGIAFPAALALASGAPSGALASCRADLAI
VATPMSGLRGMLEELRDATIPVAWLCKGFEAVPAGGETAAQGLMAHEICSQVAPRLRAGALSGPSFALEAAQGRPTALVA
ASRDAHVRELLVEAFHGPTLRVYANEDIVGVEVGGAVKNVLAIATGLCDGLDLGTNARAALITRGLAEMSRLGLALGARA
ETFMGLSGLGDLVLTATGDLSRNRRVGLALARGLTLDQAVESLGHVAEGVYSARTVVRRAGQLGVDMPIAREVVALLDGR
STASDAVARLMGRSPAAELRSC

Sequences:

>Translated_342_residues
MKIIVFGAGAWGTAMALSAAAHPAGHAVTLWARDGRQADAMQAARQNARYLPGIAFPAALALASGAPSGALASCRADLAI
VATPMSGLRGMLEELRDATIPVAWLCKGFEAVPAGGETAAQGLMAHEICSQVAPRLRAGALSGPSFALEAAQGRPTALVA
ASRDAHVRELLVEAFHGPTLRVYANEDIVGVEVGGAVKNVLAIATGLCDGLDLGTNARAALITRGLAEMSRLGLALGARA
ETFMGLSGLGDLVLTATGDLSRNRRVGLALARGLTLDQAVESLGHVAEGVYSARTVVRRAGQLGVDMPIAREVVALLDGR
STASDAVARLMGRSPAAELRSC
>Mature_342_residues
MKIIVFGAGAWGTAMALSAAAHPAGHAVTLWARDGRQADAMQAARQNARYLPGIAFPAALALASGAPSGALASCRADLAI
VATPMSGLRGMLEELRDATIPVAWLCKGFEAVPAGGETAAQGLMAHEICSQVAPRLRAGALSGPSFALEAAQGRPTALVA
ASRDAHVRELLVEAFHGPTLRVYANEDIVGVEVGGAVKNVLAIATGLCDGLDLGTNARAALITRGLAEMSRLGLALGARA
ETFMGLSGLGDLVLTATGDLSRNRRVGLALARGLTLDQAVESLGHVAEGVYSARTVVRRAGQLGVDMPIAREVVALLDGR
STASDAVARLMGRSPAAELRSC

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=312, Percent_Identity=28.2051282051282, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI24307999, Length=362, Percent_Identity=27.3480662983425, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1790037, Length=344, Percent_Identity=41.5697674418605, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17507425, Length=344, Percent_Identity=27.0348837209302, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32564403, Length=332, Percent_Identity=28.0120481927711, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193210136, Length=332, Percent_Identity=28.0120481927711, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI32564399, Length=327, Percent_Identity=27.82874617737, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193210134, Length=322, Percent_Identity=24.223602484472, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324513, Length=360, Percent_Identity=27.5, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320181, Length=298, Percent_Identity=28.5234899328859, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136200, Length=294, Percent_Identity=29.9319727891156, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136202, Length=294, Percent_Identity=29.9319727891156, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136204, Length=294, Percent_Identity=29.9319727891156, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI22026922, Length=285, Percent_Identity=25.6140350877193, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281362270, Length=245, Percent_Identity=26.9387755102041, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551945, Length=245, Percent_Identity=26.9387755102041, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648969, Length=204, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_ACIAC (A1TTW1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972173.1
- ProteinModelPortal:   A1TTW1
- SMR:   A1TTW1
- STRING:   A1TTW1
- GeneID:   4667365
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3854
- NMPDR:   fig|397945.5.peg.3288
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   ALVACCK
- PhylomeDB:   A1TTW1
- ProtClustDB:   PRK00094
- BioCyc:   AAVE397945:AAVE_3854-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34939; Mature: 34939

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 198-198 BINDING 107-107 BINDING 107-107 BINDING 147-147 BINDING 262-262 BINDING 288-288

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVFGAGAWGTAMALSAAAHPAGHAVTLWARDGRQADAMQAARQNARYLPGIAFPAAL
CEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHH
ALASGAPSGALASCRADLAIVATPMSGLRGMLEELRDATIPVAWLCKGFEAVPAGGETAA
HHHCCCCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHH
QGLMAHEICSQVAPRLRAGALSGPSFALEAAQGRPTALVAASRDAHVRELLVEAFHGPTL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCEE
RVYANEDIVGVEVGGAVKNVLAIATGLCDGLDLGTNARAALITRGLAEMSRLGLALGARA
EEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
ETFMGLSGLGDLVLTATGDLSRNRRVGLALARGLTLDQAVESLGHVAEGVYSARTVVRRA
HHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GQLGVDMPIAREVVALLDGRSTASDAVARLMGRSPAAELRSC
HCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHCC
>Mature Secondary Structure
MKIIVFGAGAWGTAMALSAAAHPAGHAVTLWARDGRQADAMQAARQNARYLPGIAFPAAL
CEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHH
ALASGAPSGALASCRADLAIVATPMSGLRGMLEELRDATIPVAWLCKGFEAVPAGGETAA
HHHCCCCCCCHHHHCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHH
QGLMAHEICSQVAPRLRAGALSGPSFALEAAQGRPTALVAASRDAHVRELLVEAFHGPTL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCEE
RVYANEDIVGVEVGGAVKNVLAIATGLCDGLDLGTNARAALITRGLAEMSRLGLALGARA
EEEECCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
ETFMGLSGLGDLVLTATGDLSRNRRVGLALARGLTLDQAVESLGHVAEGVYSARTVVRRA
HHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GQLGVDMPIAREVVALLDGRSTASDAVARLMGRSPAAELRSC
HCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA