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The map label for this gene is nadC [H]

Identifier: 120612492

GI number: 120612492

Start: 4278675

End: 4279568

Strand: Reverse

Name: nadC [H]

Synonym: Aave_3851

Alternate gene names: 120612492

Gene position: 4279568-4278675 (Counterclockwise)

Preceding gene: 120612495

Following gene: 120612491

Centisome position: 79.95

GC content: 70.69

Gene sequence:

>894_bases
ATGACGAATTTGTTTCAGCCAGCCGCCGTCCCGGCCGGCGATGCGCAATGGCAGGCCACGGTGCAGGCCGACGTGGCCCG
TGCCCTGGAAGAGGACGTGGGAGCGGGCGACCTGACCGCCGCCCTGATCGATCCGGCGCGGCGCGCGCGCGCGCGCGTGC
TGGCCCGTGAAGAGGCCGTGATTTGCGGCGCCCCCTGGGCCGAGGCCGCGCTGCGTGCGCTGGATCCGGACGTGCGGCTC
ACCTGGCGGGTGGCCGAAGGCCAGCGCTGCACGGCCGACCAGGTGGTGCTGGAGATCGAAGGCCAGGCGCGGGCGCTGCT
GAGTGCAGAGCGCACGGCGCTCAATTTCCTGCAGATGCTGTCGGCCGTGGCCACCAAGACCCGGCGCTACGTCGATGCCG
TGGCGGGTACCCGCGCGCAGATCGTGGACACGCGCAAGACCCTGCCCGGACTGCGCCTGGCGCAGAAGTACGCCGTGCGC
ATGGGTGGGGGCACCAACCACCGCATCGGGCTGCACGACGCGGTGCTCATCAAGGAAAACCACATCGCCGCCGCGGGAGG
CGTCACGGCCGTGCTGCATGCGGCGCGTGCCGCGGCCGCGCAGGCGAAGTTCATCGAGATCGAATGCGAGACGCTGGAGC
AACTGGACGAGGCGCTGTCGGCCGGCGCCCGCATGGTGCTGCTGGACAACATGCCGCTGCCGATGCTGCACGACGCCGTG
CGCCTGAATGCCGCGCATCCCGCGGGGCCGGCCATCCTGGAAATTTCCGGGGGCGTGACGCTGGAGGGCCTGCGCGCGCT
GGCCGAGACGGGCGTGGACCGTATCTCCATCGGCACGCTGACCAAGGACGTGAAGGCCACCGATTTTTCGATGCGCATGC
AGGATCCGGCCTGA

Upstream 100 bases:

>100_bases
CGAGTCTAAGCCGGCGTCGGGGCCGGCCCGCCGGAGTGTTCTCCCGGAGGCAGGGGGGCACCCGCGTCGGCGGTGCGCGT
TGCCGGTATGCTCGCGTCCC

Downstream 100 bases:

>100_bases
GCCACCCGCTGGCCGCCGCGCCGCCCCGCTCGCCGCCTGTTCGCCGCGCGTTTTCCGAAACCCCAACGAGGCCCCGCAGA
ACCGGCCCGATAGCCACCCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MTNLFQPAAVPAGDAQWQATVQADVARALEEDVGAGDLTAALIDPARRARARVLAREEAVICGAPWAEAALRALDPDVRL
TWRVAEGQRCTADQVVLEIEGQARALLSAERTALNFLQMLSAVATKTRRYVDAVAGTRAQIVDTRKTLPGLRLAQKYAVR
MGGGTNHRIGLHDAVLIKENHIAAAGGVTAVLHAARAAAAQAKFIEIECETLEQLDEALSAGARMVLLDNMPLPMLHDAV
RLNAAHPAGPAILEISGGVTLEGLRALAETGVDRISIGTLTKDVKATDFSMRMQDPA

Sequences:

>Translated_297_residues
MTNLFQPAAVPAGDAQWQATVQADVARALEEDVGAGDLTAALIDPARRARARVLAREEAVICGAPWAEAALRALDPDVRL
TWRVAEGQRCTADQVVLEIEGQARALLSAERTALNFLQMLSAVATKTRRYVDAVAGTRAQIVDTRKTLPGLRLAQKYAVR
MGGGTNHRIGLHDAVLIKENHIAAAGGVTAVLHAARAAAAQAKFIEIECETLEQLDEALSAGARMVLLDNMPLPMLHDAV
RLNAAHPAGPAILEISGGVTLEGLRALAETGVDRISIGTLTKDVKATDFSMRMQDPA
>Mature_296_residues
TNLFQPAAVPAGDAQWQATVQADVARALEEDVGAGDLTAALIDPARRARARVLAREEAVICGAPWAEAALRALDPDVRLT
WRVAEGQRCTADQVVLEIEGQARALLSAERTALNFLQMLSAVATKTRRYVDAVAGTRAQIVDTRKTLPGLRLAQKYAVRM
GGGTNHRIGLHDAVLIKENHIAAAGGVTAVLHAARAAAAQAKFIEIECETLEQLDEALSAGARMVLLDNMPLPMLHDAVR
LNAAHPAGPAILEISGGVTLEGLRALAETGVDRISIGTLTKDVKATDFSMRMQDPA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=277, Percent_Identity=37.5451263537906, Blast_Score=151, Evalue=7e-37,
Organism=Escherichia coli, GI1786299, Length=282, Percent_Identity=48.2269503546099, Blast_Score=230, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6321162, Length=281, Percent_Identity=31.3167259786477, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31540; Mature: 31408

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLFQPAAVPAGDAQWQATVQADVARALEEDVGAGDLTAALIDPARRARARVLAREEAV
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHCCEE
ICGAPWAEAALRALDPDVRLTWRVAEGQRCTADQVVLEIEGQARALLSAERTALNFLQML
EECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
SAVATKTRRYVDAVAGTRAQIVDTRKTLPGLRLAQKYAVRMGGGTNHRIGLHDAVLIKEN
HHHHHHHHHHHHHHHCCHHHEEHHHHHCCCHHHHHHHHHHCCCCCCCEECCCEEEEEECC
HIAAAGGVTAVLHAARAAAAQAKFIEIECETLEQLDEALSAGARMVLLDNMPLPMLHDAV
CEECCCHHHHHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
RLNAAHPAGPAILEISGGVTLEGLRALAETGVDRISIGTLTKDVKATDFSMRMQDPA
HCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure 
TNLFQPAAVPAGDAQWQATVQADVARALEEDVGAGDLTAALIDPARRARARVLAREEAV
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHHHHHHHHCCEE
ICGAPWAEAALRALDPDVRLTWRVAEGQRCTADQVVLEIEGQARALLSAERTALNFLQML
EECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
SAVATKTRRYVDAVAGTRAQIVDTRKTLPGLRLAQKYAVRMGGGTNHRIGLHDAVLIKEN
HHHHHHHHHHHHHHHCCHHHEEHHHHHCCCHHHHHHHHHHCCCCCCCEECCCEEEEEECC
HIAAAGGVTAVLHAARAAAAQAKFIEIECETLEQLDEALSAGARMVLLDNMPLPMLHDAV
CEECCCHHHHHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
RLNAAHPAGPAILEISGGVTLEGLRALAETGVDRISIGTLTKDVKATDFSMRMQDPA
HCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]