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The map label for this gene is livM [H]

Identifier: 120612460

GI number: 120612460

Start: 4240464

End: 4241552

Strand: Reverse

Name: livM [H]

Synonym: Aave_3819

Alternate gene names: 120612460

Gene position: 4241552-4240464 (Counterclockwise)

Preceding gene: 120612461

Following gene: 120612459

Centisome position: 79.24

GC content: 67.68

Gene sequence:

>1089_bases
ATGAAAAACCATCTTCTCGTATCGCTCAAGGCGCTGCTGGCGCAGCCACGGATGCAAAAACGCGAATGGCTCGCCCTGGC
GCTGTGTGTTCTGGCGTTCGCAGGACTGGCCCTGGTGCCCTGGGTCGCATCTCCATACGCATCGGTTGCCTTGCGCGACG
CGCTGGTGCTGGCCATCTTCGCCCTCAGCTACGACCTGCTCTGGGGCAAGGCCATGATGCTGACCCTGGGCCACGCGGTT
TTCTTCGGGGTGGGGGCCTACGGAGTCGCGATCGCGACCACGCAGCTGCAGTGGAGCTGGATCGAAGGGATGCTCCTCGG
CGTGGGCAGTTCGGCCGCGCTGGCCGCGCTCCTGGGCTGCTTCCTGCTCTACGCCGGCGTGCGCCTGCACTTTTTCGCGA
TCATCACCATGGCGGTGCTCGTCATCGCCAGGCAGGTGGCGACCAGTTGGCAGTCCGTGACGGGCGGCGATGTCGGCATT
CTGGGCGTTCCCGGCCTGCGCCTCGATGTCGCGGGCTGGCAGCTGGACCTGAGCAGCGATCGTGCTTCCTACCTCGCCGT
GCTGTGCGCGCTCGCGCTCTCTCTGCTGTTCGTCTGGGGACTGGTGCGGACACGCTATGGCCTGGTGCTGGCGGCGATCG
GCATGAACGAGTTCCGGGCCAAGCATTGCGGCTTCGATACGTCGCGGCACCTCGTGGTGGTATCCACGCTGTCCGCGGCA
CTGGCAGGCTTCGCGGGCTGTCTCTACGCGGCGTCGGCCGGCGTGGTGGCGCCCGATCTGTTCTCGGTGCTGTTGTCCAC
CGAGGTCATCCTGTGGGTGGCGGTCGGCGGCCGCGGATCGCTGCTGGGGGCGGTGGTCGCCGCCGTATTCTTCACGCGCC
TGCAGCAGGAGGTGAGCACCTACAGCACGGAGTTGTGGCCGTTGATCCTCGGAGCCCTGTTCCTGGTCTGCGTGCTGTTC
ATGCCCCGGGGCATTCCTGGCCTGCTGCGCAGGCGCGGCCCCGGGCATGCTTCCAGCGCCGCGCCCGCAAAGCAGTCCCG
GCCGGGCCGCCCGGCAGGCGTGTCCACGAATGCGGGGAGCCGGACATGA

Upstream 100 bases:

>100_bases
GTCGTGCTGCTGCTGGCCATCGTGGTGATCCGCCTTCGCCCGCGCGGCCTGGTTCCGGGCTTCAGTGCGGCCCATCAACT
GCTGGGCAAGGGGTGAAGCC

Downstream 100 bases:

>100_bases
ACGACCACGTTCCATTGCTCGAGGCGCGCGGGCTCGACGTCGCGTTCGGTGGCATCCATGCGGTGCGGCAGGTGGACATG
CGCATAGGTCCGGCAGAGCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKNHLLVSLKALLAQPRMQKREWLALALCVLAFAGLALVPWVASPYASVALRDALVLAIFALSYDLLWGKAMMLTLGHAV
FFGVGAYGVAIATTQLQWSWIEGMLLGVGSSAALAALLGCFLLYAGVRLHFFAIITMAVLVIARQVATSWQSVTGGDVGI
LGVPGLRLDVAGWQLDLSSDRASYLAVLCALALSLLFVWGLVRTRYGLVLAAIGMNEFRAKHCGFDTSRHLVVVSTLSAA
LAGFAGCLYAASAGVVAPDLFSVLLSTEVILWVAVGGRGSLLGAVVAAVFFTRLQQEVSTYSTELWPLILGALFLVCVLF
MPRGIPGLLRRRGPGHASSAAPAKQSRPGRPAGVSTNAGSRT

Sequences:

>Translated_362_residues
MKNHLLVSLKALLAQPRMQKREWLALALCVLAFAGLALVPWVASPYASVALRDALVLAIFALSYDLLWGKAMMLTLGHAV
FFGVGAYGVAIATTQLQWSWIEGMLLGVGSSAALAALLGCFLLYAGVRLHFFAIITMAVLVIARQVATSWQSVTGGDVGI
LGVPGLRLDVAGWQLDLSSDRASYLAVLCALALSLLFVWGLVRTRYGLVLAAIGMNEFRAKHCGFDTSRHLVVVSTLSAA
LAGFAGCLYAASAGVVAPDLFSVLLSTEVILWVAVGGRGSLLGAVVAAVFFTRLQQEVSTYSTELWPLILGALFLVCVLF
MPRGIPGLLRRRGPGHASSAAPAKQSRPGRPAGVSTNAGSRT
>Mature_362_residues
MKNHLLVSLKALLAQPRMQKREWLALALCVLAFAGLALVPWVASPYASVALRDALVLAIFALSYDLLWGKAMMLTLGHAV
FFGVGAYGVAIATTQLQWSWIEGMLLGVGSSAALAALLGCFLLYAGVRLHFFAIITMAVLVIARQVATSWQSVTGGDVGI
LGVPGLRLDVAGWQLDLSSDRASYLAVLCALALSLLFVWGLVRTRYGLVLAAIGMNEFRAKHCGFDTSRHLVVVSTLSAA
LAGFAGCLYAASAGVVAPDLFSVLLSTEVILWVAVGGRGSLLGAVVAAVFFTRLQQEVSTYSTELWPLILGALFLVCVLF
MPRGIPGLLRRRGPGHASSAAPAKQSRPGRPAGVSTNAGSRT

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=316, Percent_Identity=26.8987341772152, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 38197; Mature: 38197

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNHLLVSLKALLAQPRMQKREWLALALCVLAFAGLALVPWVASPYASVALRDALVLAIF
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALSYDLLWGKAMMLTLGHAVFFGVGAYGVAIATTQLQWSWIEGMLLGVGSSAALAALLGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCHHHHHHHHHH
FLLYAGVRLHFFAIITMAVLVIARQVATSWQSVTGGDVGILGVPGLRLDVAGWQLDLSSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCEEEECCCC
RASYLAVLCALALSLLFVWGLVRTRYGLVLAAIGMNEFRAKHCGFDTSRHLVVVSTLSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEHHHHHHH
LAGFAGCLYAASAGVVAPDLFSVLLSTEVILWVAVGGRGSLLGAVVAAVFFTRLQQEVST
HHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YSTELWPLILGALFLVCVLFMPRGIPGLLRRRGPGHASSAAPAKQSRPGRPAGVSTNAGS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RT
CC
>Mature Secondary Structure
MKNHLLVSLKALLAQPRMQKREWLALALCVLAFAGLALVPWVASPYASVALRDALVLAIF
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALSYDLLWGKAMMLTLGHAVFFGVGAYGVAIATTQLQWSWIEGMLLGVGSSAALAALLGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCHHHHHHHHHH
FLLYAGVRLHFFAIITMAVLVIARQVATSWQSVTGGDVGILGVPGLRLDVAGWQLDLSSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCEEEECCCC
RASYLAVLCALALSLLFVWGLVRTRYGLVLAAIGMNEFRAKHCGFDTSRHLVVVSTLSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCEEEHHHHHHH
LAGFAGCLYAASAGVVAPDLFSVLLSTEVILWVAVGGRGSLLGAVVAAVFFTRLQQEVST
HHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
YSTELWPLILGALFLVCVLFMPRGIPGLLRRRGPGHASSAAPAKQSRPGRPAGVSTNAGS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RT
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]