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The map label for this gene is livH [H]

Identifier: 120612461

GI number: 120612461

Start: 4241557

End: 4242444

Strand: Reverse

Name: livH [H]

Synonym: Aave_3820

Alternate gene names: 120612461

Gene position: 4242444-4241557 (Counterclockwise)

Preceding gene: 120612463

Following gene: 120612460

Centisome position: 79.26

GC content: 66.78

Gene sequence:

>888_bases
ATGAGTGAAGGGATCGCCCTCCTGCTGAATGTGTTGAGCCAGGTGGCCGTGCTGGCCCTGGTTGCGCTGGGCCTGGCCAT
CGTGTTCGGCATGATGGATATCGTGAATCTCGCGCATGGCGAGTTCGTCACCCTCGGGGCTTTCACCCTCGCGGTGCTGC
AGGGCGCTGGGGGCGCGCAGGCCTACTGGCTGGCGCTGGTCATCGCGCCGATCGTGGGGGCCGTGGCGGGGCTGGCGCTC
GAAGCCTCGGTGATCCGCTTTCTCTACCACCGGACGCTGGACACGCTCCTCGCGACCTATGCCGTGAGCCTGATCATCCA
GAAGCTGCTCGAAATCGGCTTCGGCAAGCATCCGCAGATGGTCTATACGCCCCTCGCGGGTTCGGTGAGCGTGCTGGGGG
CGAGCTATCCGTCCTACCGCCTGTTCGTCATCGTGGCGAGCATCGTGGTGATCGCGGCCTGCGCGCTGGCGTTCACGCGC
ACTCGTTTCGGGCTGCACCTGAGGGCGGTCATCCAGAACCCCTCCATGTCCTCCGCGCTGGGAATAGACACCCGGCACAT
GAACCGCCTGGCGTTCGCCTGCGGAGCCGCGCTCGCGGCTTTCGCCGGCGTGCTGGTGGCGCCGCTGGTATCCGTGGAGA
GCCACCTGGGCATGGCCTACCTCGGCAAGGCGTTCTTCGTGATCGTCGTGGGAGGCATCGGCAGCGTGCTGGGCGCGGTC
ACGGGCAGCGTGCTGATCGGCAGCACGGAGACGCTGCTGAACTACCACATCGATCCTTCGATGGCGTCGGCGGTCGTGCT
GCTGCTGGCCATCGTGGTGATCCGCCTTCGCCCGCGCGGCCTGGTTCCGGGCTTCAGTGCGGCCCATCAACTGCTGGGCA
AGGGGTGA

Upstream 100 bases:

>100_bases
CGTACCGGGTATGGGAATCGGTGCCGCGACGGCGGCATCCGCGAGCCGGAGTGCCGGCGGCGGGCAGCGGCAGCGGCGGT
GTGCCGCGCAGGGGGCAGCC

Downstream 100 bases:

>100_bases
AGCCATGAAAAACCATCTTCTCGTATCGCTCAAGGCGCTGCTGGCGCAGCCACGGATGCAAAAACGCGAATGGCTCGCCC
TGGCGCTGTGTGTTCTGGCG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSEGIALLLNVLSQVAVLALVALGLAIVFGMMDIVNLAHGEFVTLGAFTLAVLQGAGGAQAYWLALVIAPIVGAVAGLAL
EASVIRFLYHRTLDTLLATYAVSLIIQKLLEIGFGKHPQMVYTPLAGSVSVLGASYPSYRLFVIVASIVVIAACALAFTR
TRFGLHLRAVIQNPSMSSALGIDTRHMNRLAFACGAALAAFAGVLVAPLVSVESHLGMAYLGKAFFVIVVGGIGSVLGAV
TGSVLIGSTETLLNYHIDPSMASAVVLLLAIVVIRLRPRGLVPGFSAAHQLLGKG

Sequences:

>Translated_295_residues
MSEGIALLLNVLSQVAVLALVALGLAIVFGMMDIVNLAHGEFVTLGAFTLAVLQGAGGAQAYWLALVIAPIVGAVAGLAL
EASVIRFLYHRTLDTLLATYAVSLIIQKLLEIGFGKHPQMVYTPLAGSVSVLGASYPSYRLFVIVASIVVIAACALAFTR
TRFGLHLRAVIQNPSMSSALGIDTRHMNRLAFACGAALAAFAGVLVAPLVSVESHLGMAYLGKAFFVIVVGGIGSVLGAV
TGSVLIGSTETLLNYHIDPSMASAVVLLLAIVVIRLRPRGLVPGFSAAHQLLGKG
>Mature_294_residues
SEGIALLLNVLSQVAVLALVALGLAIVFGMMDIVNLAHGEFVTLGAFTLAVLQGAGGAQAYWLALVIAPIVGAVAGLALE
ASVIRFLYHRTLDTLLATYAVSLIIQKLLEIGFGKHPQMVYTPLAGSVSVLGASYPSYRLFVIVASIVVIAACALAFTRT
RFGLHLRAVIQNPSMSSALGIDTRHMNRLAFACGAALAAFAGVLVAPLVSVESHLGMAYLGKAFFVIVVGGIGSVLGAVT
GSVLIGSTETLLNYHIDPSMASAVVLLLAIVVIRLRPRGLVPGFSAAHQLLGKG

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=290, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30528; Mature: 30397

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SEGIALLLNVLSQVAVLALVALGLAIVFGMMDIVNLAHGEFVTLGAFTLAVLQGAGGAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHH
AYWLALVIAPIVGAVAGLALEASVIRFLYHRTLDTLLATYAVSLIIQKLLEIGFGKHPQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VYTPLAGSVSVLGASYPSYRLFVIVASIVVIAACALAFTRTRFGLHLRAVIQNPSMSSAL
EEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
GIDTRHMNRLAFACGAALAAFAGVLVAPLVSVESHLGMAYLGKAFFVIVVGGIGSVLGAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
TGSVLIGSTETLLNYHIDPSMASAVVLLLAIVVIRLRPRGLVPGFSAAHQLLGKG
HHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]