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The map label for this gene is lysA [H]

Identifier: 120612446

GI number: 120612446

Start: 4226961

End: 4228175

Strand: Direct

Name: lysA [H]

Synonym: Aave_3805

Alternate gene names: 120612446

Gene position: 4226961-4228175 (Clockwise)

Preceding gene: 120612445

Following gene: 120612447

Centisome position: 78.97

GC content: 68.97

Gene sequence:

>1215_bases
ATGACGATCCTCGACACCTTCACGACCCGGGACGGCGCTATCGAAATCGGCGGCCTGCCCCTGTCACGCCTGGCGGAGCG
GGCCGGCCGCACGCCGTTCTTCGCTTACGACCGGAGCAAGCTGGCCGAGCGCGTGGCGCTGCTGCGGCGCTGGCTCGCTC
CCGACATCCGCATCCACTACTCCATCAAGGCCAATCCCATGCCGGCGCTCGTGCATTGCATGGCCGGGCTGGTGGACGGC
TTCGACGTGGCGTCGGCCGGCGAGTTGCGGGTGGCTCTGGATACCGGCATGGCCGCCGAGCACATCGCGCTGGCCGGTCC
GGGCAAGACAGAACTCGACGTGCGCAGCACCGTCGGCGCCGGAGCGACCCTCACGCTGGAATCGGTCCATCAGCTCGACG
CCGCCGCACGCGCAGGCCAGGCTCTGGGCGTGCGCCCGCGCGTGGCCCTGCGCATCAATCCGGACTTCCAGCCGAAAACC
AGCGGCATGCGCATGGGCGGAGGCCCGCGCCAGTTCGGCATCGACGCGGAACAGGCGCCCGGCGTGCTGGCCGCCATCGC
GCAGCGCGACCTCGACTTCCGCGGTTTCCACGTGTTCTGGGGATCGCAGTGCCTGGACGCCGACACGGTGATCTCGGCGC
AGCGGCATGTGGCCGAACTCGTTGTCCGGCTCGCCGACCAGGCGAACGCTCCCGTGGCCTTCGTCAACATGGGGGGCGGC
TTCGGCATCCCGTACTTCGAGAATGAACGCGCGCTGGACCTGGAGCCCATCGGCGCGGCCATGCGGCAATGGCTCGTGCC
GCTGCGGCAGCGGTTGCCCGAAGCGCGGCTGGCGATGGAGTTCGGCCGCTATCTGGTCGGCGAGGCAGGCATCTATGTCT
GTCGGATCCTGGACAAGAAGGTGTCCCGGGGAGAAACCTTTCTGGTGACCGACGGCGGCCTGCACCACCAGCTCGCGGCG
TCGGGGAATTTCGGTCAGGTGCTGCGGCGCAACTACCCCGTGGCGATCGGCAACAAATCCGGCCTTCCGGCCACGGAAAC
CTGCCACATCGTCGGATGTCTTTGCACACCGCTCGACCGGATCGCGGACCGCGTCGCGCTTGCCTCGCCGGACATCGGCG
ACTTCGTGGTGGTGGCGCAATCCGGCGCGTACGGGCGCAGCGCCAGCCCGGCCGCCTTCCTGAGCCATCCCGAACCTGCA
GAAATCCTGGTCTGA

Upstream 100 bases:

>100_bases
CCCGCGCCATCCACGTGCGCAGCACGATCCAGCGCAATCCCAACGGCAAGTTCGACCGCGCGGCACTGCAGCGCGAACTC
TCCATCGCAACGGAGGCGGT

Downstream 100 bases:

>100_bases
CACCAGCCGAGAGGAATCACCATGTCCCTGGTATCCCCCGAATCCCAAACCGATCCGCGCGACTTCTCGCTGCGGTTGAG
CGAAGACGAGTGCAGCATGC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTILDTFTTRDGAIEIGGLPLSRLAERAGRTPFFAYDRSKLAERVALLRRWLAPDIRIHYSIKANPMPALVHCMAGLVDG
FDVASAGELRVALDTGMAAEHIALAGPGKTELDVRSTVGAGATLTLESVHQLDAAARAGQALGVRPRVALRINPDFQPKT
SGMRMGGGPRQFGIDAEQAPGVLAAIAQRDLDFRGFHVFWGSQCLDADTVISAQRHVAELVVRLADQANAPVAFVNMGGG
FGIPYFENERALDLEPIGAAMRQWLVPLRQRLPEARLAMEFGRYLVGEAGIYVCRILDKKVSRGETFLVTDGGLHHQLAA
SGNFGQVLRRNYPVAIGNKSGLPATETCHIVGCLCTPLDRIADRVALASPDIGDFVVVAQSGAYGRSASPAAFLSHPEPA
EILV

Sequences:

>Translated_404_residues
MTILDTFTTRDGAIEIGGLPLSRLAERAGRTPFFAYDRSKLAERVALLRRWLAPDIRIHYSIKANPMPALVHCMAGLVDG
FDVASAGELRVALDTGMAAEHIALAGPGKTELDVRSTVGAGATLTLESVHQLDAAARAGQALGVRPRVALRINPDFQPKT
SGMRMGGGPRQFGIDAEQAPGVLAAIAQRDLDFRGFHVFWGSQCLDADTVISAQRHVAELVVRLADQANAPVAFVNMGGG
FGIPYFENERALDLEPIGAAMRQWLVPLRQRLPEARLAMEFGRYLVGEAGIYVCRILDKKVSRGETFLVTDGGLHHQLAA
SGNFGQVLRRNYPVAIGNKSGLPATETCHIVGCLCTPLDRIADRVALASPDIGDFVVVAQSGAYGRSASPAAFLSHPEPA
EILV
>Mature_403_residues
TILDTFTTRDGAIEIGGLPLSRLAERAGRTPFFAYDRSKLAERVALLRRWLAPDIRIHYSIKANPMPALVHCMAGLVDGF
DVASAGELRVALDTGMAAEHIALAGPGKTELDVRSTVGAGATLTLESVHQLDAAARAGQALGVRPRVALRINPDFQPKTS
GMRMGGGPRQFGIDAEQAPGVLAAIAQRDLDFRGFHVFWGSQCLDADTVISAQRHVAELVVRLADQANAPVAFVNMGGGF
GIPYFENERALDLEPIGAAMRQWLVPLRQRLPEARLAMEFGRYLVGEAGIYVCRILDKKVSRGETFLVTDGGLHHQLAAS
GNFGQVLRRNYPVAIGNKSGLPATETCHIVGCLCTPLDRIADRVALASPDIGDFVVVAQSGAYGRSASPAAFLSHPEPAE
ILV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=406, Percent_Identity=25.3694581280788, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789203, Length=392, Percent_Identity=25.765306122449, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562780, Length=397, Percent_Identity=24.1813602015113, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 43248; Mature: 43117

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILDTFTTRDGAIEIGGLPLSRLAERAGRTPFFAYDRSKLAERVALLRRWLAPDIRIHY
CCEECCCCCCCCCEEECCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEE
SIKANPMPALVHCMAGLVDGFDVASAGELRVALDTGMAAEHIALAGPGKTELDVRSTVGA
EEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCEEEHHHCCC
GATLTLESVHQLDAAARAGQALGVRPRVALRINPDFQPKTSGMRMGGGPRQFGIDAEQAP
CCEEEHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCCHHHCC
GVLAAIAQRDLDFRGFHVFWGSQCLDADTVISAQRHVAELVVRLADQANAPVAFVNMGGG
CHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
FGIPYFENERALDLEPIGAAMRQWLVPLRQRLPEARLAMEFGRYLVGEAGIYVCRILDKK
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEHHHHHHH
VSRGETFLVTDGGLHHQLAASGNFGQVLRRNYPVAIGNKSGLPATETCHIVGCLCTPLDR
HCCCCEEEEECCCCCEEEECCCCHHHHHHCCCCEEECCCCCCCCCCHHEEEHHHHCCHHH
IADRVALASPDIGDFVVVAQSGAYGRSASPAAFLSHPEPAEILV
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCHHHCC
>Mature Secondary Structure 
TILDTFTTRDGAIEIGGLPLSRLAERAGRTPFFAYDRSKLAERVALLRRWLAPDIRIHY
CEECCCCCCCCCEEECCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEE
SIKANPMPALVHCMAGLVDGFDVASAGELRVALDTGMAAEHIALAGPGKTELDVRSTVGA
EEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCEEEHHHCCC
GATLTLESVHQLDAAARAGQALGVRPRVALRINPDFQPKTSGMRMGGGPRQFGIDAEQAP
CCEEEHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEECCCCCCCCCCCHHHCC
GVLAAIAQRDLDFRGFHVFWGSQCLDADTVISAQRHVAELVVRLADQANAPVAFVNMGGG
CHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
FGIPYFENERALDLEPIGAAMRQWLVPLRQRLPEARLAMEFGRYLVGEAGIYVCRILDKK
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEHHHHHHH
VSRGETFLVTDGGLHHQLAASGNFGQVLRRNYPVAIGNKSGLPATETCHIVGCLCTPLDR
HCCCCEEEEECCCCCEEEECCCCHHHHHHCCCCEEECCCCCCCCCCHHEEEHHHHCCHHH
IADRVALASPDIGDFVVVAQSGAYGRSASPAAFLSHPEPAEILV
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]