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The map label for this gene is norM [H]

Identifier: 120612444

GI number: 120612444

Start: 4223985

End: 4225391

Strand: Direct

Name: norM [H]

Synonym: Aave_3803

Alternate gene names: 120612444

Gene position: 4223985-4225391 (Clockwise)

Preceding gene: 120612443

Following gene: 120612445

Centisome position: 78.91

GC content: 71.29

Gene sequence:

>1407_bases
ATGCGACCGACCGACCCGAGCAGCCAGCACGCCCCGGCACATGCGCCCTGGCGTTCCGAAGCGCGCGCCTCGCTGTCACT
GACCCTCCATCTGCTGATCGGGCAGACCGCATTGATGTCGCTGCCCCTGGCCGATCTGCTGTCCGTGGCGTCCCTGGGCA
GGCACGCCCTGGCGGCCGTCGGCCTGGTCAATAGCGTCGCGGCGCTGCTGACCCTGGTCTGTTTCGGCGTCCTGCAGGCG
GTCGCGCCACTGGCCGGCGCTGCGCTGGGGCGCGGTGGCGGGCCGGCCGTGGCGCGAAAGGTGGTCGGCGACGGCCTGCG
GATCGCTTCCGGCCTCGGCGTGCTCAACAGCGGCCTGTTGCTGCTTTTCGCTGTGCTGCTGCCCGGCCTGGGGCAGGAGC
CGGAGGTGGCGCGGCAGGCCCAGCACTACGCGGCGGCCCTGGCCCCCGGTATGCTGGCCGCGGCCTGGCTGGCCGCCTGG
CGGGTCGGGCTGCCGGTGCTGGGCCGCGTGCGCTCGCTGTCAATCACGCTGTCCGCATGCGCTGCGCTGCACTTCGCGGC
GAACCATGTCCTCGTCCACGGCATGGCAGGCTTGCCGGCGTTGGGGATGGCGGGGCTGGGGTGGAGCTATGCCGTCACGT
ATGGCACGGGGGTGCTCGTGCTCCACCTGCTTGATCGGCGGCCGGTACCGCAAGGGGCGGGACAGCCTCACGCGCCTTCA
TCGGCCAGGGCGTTGCTGCGCATCGGCCTGCCCATCGGTGCGGTCATGGGCATCGAATACATGCTGTTCACCGGGTCCAC
CGTGCTCATGGGACGGCACGGAAGCTCGGCCCTTGCGGCACACGCCGTCGCGCTCCAATGGGTCACGCTGGCATTCGTCA
TTCCGCTCGCCGCATCCCACACCGTGCTCACGCGCCTGTCGCTGGCGATCGGACACGCGGACGCGGATGCCGCGCGTCGC
TCCACGGCGGCGGCCTGCGTGATCGCGGGCGTCTTCCATGCGCTGGTGGCGGGTGCCTGGCTGTGGGTTCCCGAGGCGTT
CGCCAGCGCCCTGCTGCCGGTGCCCATCCGGGACAGGGACGACCTCGTGGCGACGGCCGCTGCGCTGCTGCGCGTTGGCG
CGCTGCTGCAGGCGCTCAACGGTTTCGTGGTGGTGCTGGCAGCCGTGCTGCGCGCCTGCCGCGACACCAGCGCGATCCTC
TGGCAGGTGCTCTTCGGCTACTGGGTGATCGGCCTGGGCAGTGCCGCGCTTCTCGGCAGCATGGCCGGCCCTGCGGGGAT
CTGGTGGGGCATGGCGCTCGGCTTCGGCGTGGCGCTCGTGCTGGTGCTGCATCGCGTACGACGGCGGCTCACCCGCCTGA
ACGACGTTTTTCAACCGACGGAGGAAATCCATGCGCAATCTCGTTGA

Upstream 100 bases:

>100_bases
CGCACGAGAACAAGCGGCCCGGCGGCAACTATGTTCTCTTCTCGAGCGGGCTGGCGGGCTGCTTCGGCACCCTCGTGCTG
CGCCATTGACGGAGCCGGCG

Downstream 100 bases:

>100_bases
ACTGATATGCCACAGCGCCGACCGCGCTCCCGGCGCACAAGCCCTGGTCGATGGAGACCATCGGCTGGACTACGCCACGC
TGCGCGACCATGTGCTGTCG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MRPTDPSSQHAPAHAPWRSEARASLSLTLHLLIGQTALMSLPLADLLSVASLGRHALAAVGLVNSVAALLTLVCFGVLQA
VAPLAGAALGRGGGPAVARKVVGDGLRIASGLGVLNSGLLLLFAVLLPGLGQEPEVARQAQHYAAALAPGMLAAAWLAAW
RVGLPVLGRVRSLSITLSACAALHFAANHVLVHGMAGLPALGMAGLGWSYAVTYGTGVLVLHLLDRRPVPQGAGQPHAPS
SARALLRIGLPIGAVMGIEYMLFTGSTVLMGRHGSSALAAHAVALQWVTLAFVIPLAASHTVLTRLSLAIGHADADAARR
STAAACVIAGVFHALVAGAWLWVPEAFASALLPVPIRDRDDLVATAAALLRVGALLQALNGFVVVLAAVLRACRDTSAIL
WQVLFGYWVIGLGSAALLGSMAGPAGIWWGMALGFGVALVLVLHRVRRRLTRLNDVFQPTEEIHAQSR

Sequences:

>Translated_468_residues
MRPTDPSSQHAPAHAPWRSEARASLSLTLHLLIGQTALMSLPLADLLSVASLGRHALAAVGLVNSVAALLTLVCFGVLQA
VAPLAGAALGRGGGPAVARKVVGDGLRIASGLGVLNSGLLLLFAVLLPGLGQEPEVARQAQHYAAALAPGMLAAAWLAAW
RVGLPVLGRVRSLSITLSACAALHFAANHVLVHGMAGLPALGMAGLGWSYAVTYGTGVLVLHLLDRRPVPQGAGQPHAPS
SARALLRIGLPIGAVMGIEYMLFTGSTVLMGRHGSSALAAHAVALQWVTLAFVIPLAASHTVLTRLSLAIGHADADAARR
STAAACVIAGVFHALVAGAWLWVPEAFASALLPVPIRDRDDLVATAAALLRVGALLQALNGFVVVLAAVLRACRDTSAIL
WQVLFGYWVIGLGSAALLGSMAGPAGIWWGMALGFGVALVLVLHRVRRRLTRLNDVFQPTEEIHAQSR
>Mature_468_residues
MRPTDPSSQHAPAHAPWRSEARASLSLTLHLLIGQTALMSLPLADLLSVASLGRHALAAVGLVNSVAALLTLVCFGVLQA
VAPLAGAALGRGGGPAVARKVVGDGLRIASGLGVLNSGLLLLFAVLLPGLGQEPEVARQAQHYAAALAPGMLAAAWLAAW
RVGLPVLGRVRSLSITLSACAALHFAANHVLVHGMAGLPALGMAGLGWSYAVTYGTGVLVLHLLDRRPVPQGAGQPHAPS
SARALLRIGLPIGAVMGIEYMLFTGSTVLMGRHGSSALAAHAVALQWVTLAFVIPLAASHTVLTRLSLAIGHADADAARR
STAAACVIAGVFHALVAGAWLWVPEAFASALLPVPIRDRDDLVATAAALLRVGALLQALNGFVVVLAAVLRACRDTSAIL
WQVLFGYWVIGLGSAALLGSMAGPAGIWWGMALGFGVALVLVLHRVRRRLTRLNDVFQPTEEIHAQSR

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=459, Percent_Identity=25.0544662309368, Blast_Score=92, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48288; Mature: 48288

Theoretical pI: Translated: 11.44; Mature: 11.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPTDPSSQHAPAHAPWRSEARASLSLTLHLLIGQTALMSLPLADLLSVASLGRHALAAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GLVNSVAALLTLVCFGVLQAVAPLAGAALGRGGGPAVARKVVGDGLRIASGLGVLNSGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
LLFAVLLPGLGQEPEVARQAQHYAAALAPGMLAAAWLAAWRVGLPVLGRVRSLSITLSAC
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AALHFAANHVLVHGMAGLPALGMAGLGWSYAVTYGTGVLVLHLLDRRPVPQGAGQPHAPS
HHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
SARALLRIGLPIGAVMGIEYMLFTGSTVLMGRHGSSALAAHAVALQWVTLAFVIPLAASH
HHHHHHHHCCCHHHHHHHHHHEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TVLTRLSLAIGHADADAARRSTAAACVIAGVFHALVAGAWLWVPEAFASALLPVPIRDRD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
DLVATAAALLRVGALLQALNGFVVVLAAVLRACRDTSAILWQVLFGYWVIGLGSAALLGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHH
MAGPAGIWWGMALGFGVALVLVLHRVRRRLTRLNDVFQPTEEIHAQSR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA