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The map label for this gene is rppH

Identifier: 120612315

GI number: 120612315

Start: 4048548

End: 4049228

Strand: Direct

Name: rppH

Synonym: Aave_3671

Alternate gene names: 120612315

Gene position: 4048548-4049228 (Clockwise)

Preceding gene: 120612312

Following gene: 120612320

Centisome position: 75.63

GC content: 67.84

Gene sequence:

>681_bases
ATGCTCGACCGGGACGGTTTTCGGCCCAACGTCGGCATCATCCTGCTCAACCAGAGGAACCAGGTGTTCTGGGGCAAGCG
GATCCGCACCCACAGCTGGCAGTTCCCGCAGGGTGGCATCGATCGGGGGGAGACCCCCGAGCAGGCCATGTTCCGCGAAC
TGCACGAGGAGGTGGGGCTGCAGCCGTGCCACGTCCGCGTGGTGGCCCGCACAAGGGACTGGTTGCGCTACGAGGTGCCA
GACCGGTACATCCGCCGTGATGCACGCGGCCATTACAAGGGCCAGAAGCAGATCTGGTTCCTGCTCCAGCTGGTCGGCCA
CGACTGGGATCTGAACCTCCGGGCGACCAACCACCCCGAGTTCGATGCCTGGCGCTGGAACGACTACTGGGTTCCGCTGG
ACGTCGTCGTGGAGTTCAAGCGCGGCGTCTATGAAATGGCCCTGACCGAACTGGCGCGCTTCCTGCCGCGCAACGACCAG
CGCAACCGGTACCTGCGCAGCGGCATGCGCCAGCGCGAAGGCGCCCCGGAGGTCTCGCTCGGCACCACGACGCAGCTGCG
GACCACGTCCCTGCTGGTCCACCCGGGCATGGAGCTGCCGCCAGGCGCCAGCTTCGATCCCGATCCCCGGACGGGGGACG
GCGACCCGGGCATGCCCGGCATCCACAAACCGGCCGGCTGA

Upstream 100 bases:

>100_bases
GCTTTCATTGCACGAGGGAATTCACCATCCGGGCCGGTACGCTTGCCGCGCACCCATGCCCGTGCATAATGGATACAGTT
TTAAAAATTGGGGTTAGATT

Downstream 100 bases:

>100_bases
AACGACCACGCAAAAAAAAGGCGCTCCCTGGAGCGCCCTTTTTTTGCGATGCTGCCGGCTCAGCCGCCGGACAGCACGAG
GTTGTCACGGTGCACCATTT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MLDRDGFRPNVGIILLNQRNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGLQPCHVRVVARTRDWLRYEVP
DRYIRRDARGHYKGQKQIWFLLQLVGHDWDLNLRATNHPEFDAWRWNDYWVPLDVVVEFKRGVYEMALTELARFLPRNDQ
RNRYLRSGMRQREGAPEVSLGTTTQLRTTSLLVHPGMELPPGASFDPDPRTGDGDPGMPGIHKPAG

Sequences:

>Translated_226_residues
MLDRDGFRPNVGIILLNQRNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGLQPCHVRVVARTRDWLRYEVP
DRYIRRDARGHYKGQKQIWFLLQLVGHDWDLNLRATNHPEFDAWRWNDYWVPLDVVVEFKRGVYEMALTELARFLPRNDQ
RNRYLRSGMRQREGAPEVSLGTTTQLRTTSLLVHPGMELPPGASFDPDPRTGDGDPGMPGIHKPAG
>Mature_226_residues
MLDRDGFRPNVGIILLNQRNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGLQPCHVRVVARTRDWLRYEVP
DRYIRRDARGHYKGQKQIWFLLQLVGHDWDLNLRATNHPEFDAWRWNDYWVPLDVVVEFKRGVYEMALTELARFLPRNDQ
RNRYLRSGMRQREGAPEVSLGTTTQLRTTSLLVHPGMELPPGASFDPDPRTGDGDPGMPGIHKPAG

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=155, Percent_Identity=54.1935483870968, Blast_Score=182, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_ACIAC (A1TTD1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_971993.1
- ProteinModelPortal:   A1TTD1
- SMR:   A1TTD1
- STRING:   A1TTD1
- GeneID:   4665396
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_3671
- NMPDR:   fig|397945.5.peg.3135
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   A1TTD1
- ProtClustDB:   PRK00714
- BioCyc:   AAVE397945:AAVE_3671-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 26390; Mature: 26390

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRDGFRPNVGIILLNQRNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
QPCHVRVVARTRDWLRYEVPDRYIRRDARGHYKGQKQIWFLLQLVGHDWDLNLRATNHPE
CCEEEEEEECCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWNDYWVPLDVVVEFKRGVYEMALTELARFLPRNDQRNRYLRSGMRQREGAPEVSL
CCCEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
GTTTQLRTTSLLVHPGMELPPGASFDPDPRTGDGDPGMPGIHKPAG
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDRDGFRPNVGIILLNQRNQVFWGKRIRTHSWQFPQGGIDRGETPEQAMFRELHEEVGL
CCCCCCCCCCCCEEEECCCCCEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
QPCHVRVVARTRDWLRYEVPDRYIRRDARGHYKGQKQIWFLLQLVGHDWDLNLRATNHPE
CCEEEEEEECCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCC
FDAWRWNDYWVPLDVVVEFKRGVYEMALTELARFLPRNDQRNRYLRSGMRQREGAPEVSL
CCCEECCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
GTTTQLRTTSLLVHPGMELPPGASFDPDPRTGDGDPGMPGIHKPAG
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA