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The map label for this gene is adk

Identifier: 120611230

GI number: 120611230

Start: 2813629

End: 2814285

Strand: Reverse

Name: adk

Synonym: Aave_2561

Alternate gene names: 120611230

Gene position: 2814285-2813629 (Counterclockwise)

Preceding gene: 120611231

Following gene: 120611229

Centisome position: 52.58

GC content: 65.6

Gene sequence:

>657_bases
ATGAGACTGATTCTTTTGGGCGCGCCCGGCGCCGGGAAGGGCACGCAAGCCGCGTTCATCTGCCAGAAATACGGCATTCC
GCAGATCTCCACCGGCGACATGCTGCGCGCCGCCGTGAAGGCTGGCACGCCGCTGGGACAGCAGGCCAAGGCCGTCATGG
ATGCCGGCAAGCTGGTGAGCGACGACCTCATCATCAATCTCGTGAAGGACCGCATCGCCCAGCCGGACTGCGCCAAGGGC
TTCCTCTTCGACGGTTTTCCGCGCACCATTCCCCAGGCCGATGCCATGAAGGCCGCTGGCGTCAAGCTCGACTACGTGCT
GGAGATCGACGTGCCGTTCGATGCCATCATCGAGCGCATGAGCGGCCGCCGCTCGCACCCGGCCAGCGGCCGCACCTACC
ACGTGAAGTTCAACCCGCCCAAGGTGGAAGGCAAGGACGACGTCACCGGCGAGGACCTGATCCAGCGCGAGGACGACAAG
GAAGACACGGTGAAGAAGCGCCTGGAGGTGTACAGCGCGCAGACGCGCCCGCTCGTGGAGTACTACTCCACCTGGGCGAA
GAACGATCCGGCCAACGCCCCCAAATACCGCGCCATCAGCGGTACCGGCACGGTGGAGGAAATCACCCGGCGTGCGCTGG
CCGCCCTGGCGGACTGA

Upstream 100 bases:

>100_bases
ACCCGCATGCTATCCTTGCCCGCGATTGAAGCGCCAACCCGGGCCTACGGCAAGCCCCGGGCTTCCGGCGCTGGCTGATT
TCAACACTTAGAGGACCTCC

Downstream 100 bases:

>100_bases
GTGCCTGGCACAGGGCCGGCGCCTTTCCGGCCCTTGACCGACGCCGCCCTCCGGGCGGCGTTTTCGTTTCCGGACCGGGG
GGGCCTAGGTGTGATGTCTC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRLILLGAPGAGKGTQAAFICQKYGIPQISTGDMLRAAVKAGTPLGQQAKAVMDAGKLVSDDLIINLVKDRIAQPDCAKG
FLFDGFPRTIPQADAMKAAGVKLDYVLEIDVPFDAIIERMSGRRSHPASGRTYHVKFNPPKVEGKDDVTGEDLIQREDDK
EDTVKKRLEVYSAQTRPLVEYYSTWAKNDPANAPKYRAISGTGTVEEITRRALAALAD

Sequences:

>Translated_218_residues
MRLILLGAPGAGKGTQAAFICQKYGIPQISTGDMLRAAVKAGTPLGQQAKAVMDAGKLVSDDLIINLVKDRIAQPDCAKG
FLFDGFPRTIPQADAMKAAGVKLDYVLEIDVPFDAIIERMSGRRSHPASGRTYHVKFNPPKVEGKDDVTGEDLIQREDDK
EDTVKKRLEVYSAQTRPLVEYYSTWAKNDPANAPKYRAISGTGTVEEITRRALAALAD
>Mature_218_residues
MRLILLGAPGAGKGTQAAFICQKYGIPQISTGDMLRAAVKAGTPLGQQAKAVMDAGKLVSDDLIINLVKDRIAQPDCAKG
FLFDGFPRTIPQADAMKAAGVKLDYVLEIDVPFDAIIERMSGRRSHPASGRTYHVKFNPPKVEGKDDVTGEDLIQREDDK
EDTVKKRLEVYSAQTRPLVEYYSTWAKNDPANAPKYRAISGTGTVEEITRRALAALAD

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=186, Percent_Identity=51.6129032258064, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI4502013, Length=186, Percent_Identity=51.6129032258064, Blast_Score=204, Evalue=6e-53,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=47.2527472527472, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=40.7608695652174, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=40.7608695652174, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=40.7608695652174, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=40.7608695652174, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI22749187, Length=187, Percent_Identity=31.0160427807487, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI4502011, Length=192, Percent_Identity=30.7291666666667, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI28144899, Length=194, Percent_Identity=26.8041237113402, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI28144897, Length=194, Percent_Identity=26.8041237113402, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI7706497, Length=204, Percent_Identity=28.921568627451, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786680, Length=208, Percent_Identity=67.7884615384615, Blast_Score=288, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17552384, Length=199, Percent_Identity=46.2311557788945, Blast_Score=189, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=32.5581395348837, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=193, Percent_Identity=34.1968911917098, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=29.3478260869565, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=202, Percent_Identity=48.5148514851485, Blast_Score=204, Evalue=8e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=44.6236559139785, Blast_Score=151, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=29.7872340425532, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=45.7547169811321, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=45.6043956043956, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=45.6043956043956, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=33.5195530726257, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=33.5195530726257, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=27.1739130434783, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=27.1739130434783, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ACIAC (A1TQ96)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_970908.1
- ProteinModelPortal:   A1TQ96
- SMR:   A1TQ96
- STRING:   A1TQ96
- GeneID:   4665128
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_2561
- NMPDR:   fig|397945.5.peg.2196
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   A1TQ96
- ProtClustDB:   PRK00279
- BioCyc:   AAVE397945:AAVE_2561-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23720; Mature: 23720

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQAAFICQKYGIPQISTGDMLRAAVKAGTPLGQQAKAVMDAGKLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DDLIINLVKDRIAQPDCAKGFLFDGFPRTIPQADAMKAAGVKLDYVLEIDVPFDAIIERM
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRSHPASGRTYHVKFNPPKVEGKDDVTGEDLIQREDDKEDTVKKRLEVYSAQTRPLVE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
YYSTWAKNDPANAPKYRAISGTGTVEEITRRALAALAD
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQAAFICQKYGIPQISTGDMLRAAVKAGTPLGQQAKAVMDAGKLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
DDLIINLVKDRIAQPDCAKGFLFDGFPRTIPQADAMKAAGVKLDYVLEIDVPFDAIIERM
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRSHPASGRTYHVKFNPPKVEGKDDVTGEDLIQREDDKEDTVKKRLEVYSAQTRPLVE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
YYSTWAKNDPANAPKYRAISGTGTVEEITRRALAALAD
HHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA