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The map label for this gene is cyp18 [H]

Identifier: 120610988

GI number: 120610988

Start: 2544390

End: 2544896

Strand: Reverse

Name: cyp18 [H]

Synonym: Aave_2316

Alternate gene names: 120610988

Gene position: 2544896-2544390 (Counterclockwise)

Preceding gene: 120610989

Following gene: 120610987

Centisome position: 47.54

GC content: 63.31

Gene sequence:

>507_bases
ATGAGCAACCCGCAAGTCGAACTCCATATCGCCGGCCACGGCGTGATCGTCCTCGAACTCGACGCCGACAAGGCGCCCAA
GTCCACGGAGAACTTTCTCGCCTACGTGAAGAAGGGTCACTACGACAACACGATCTTCCACCGCGTGATCCCCGGCTTCA
TGATCCAGGGCGGCGGCTTCGAGCCCGGCATGAACCAGAAGGGCACCGATGCGCCCATCGAGAACGAGGCCCAGAACGGC
CTGAAGAACGACAAGTACACCGTGGCCATGGCCCGCACCAGCGATCCGCACTCGGCCACCGCGCAGTTCTTCATCAACGT
GGCCGACAACGGCTTCCTGAACCACACCGCGCCGTCCGCCCAGGGCTGGGGCTACGCCGTGTTCGGCAAGGTGGTCAAGG
GCACCGAGATCGTGGACGCCATCAAGGGCGTGAAAACGGGCCGCAAGGGCTTCCACGACGACGTGCCGAAGGACGACGTC
ATCATCGAAAAGGCCGTGGTGGCCTGA

Upstream 100 bases:

>100_bases
CCGCGACGCCGGTCGTGATCAAATCCGCCACCGTGGTGCAGTGAGCCACCCTCGCCCGCATCTGCAACATCCCCACCCGG
GATCCCCATAAGGAAACGCA

Downstream 100 bases:

>100_bases
TTCCCCCCTGAGTCGCTTCGCGCCTTCCCCCCTGGGGGACGACGCCGGCAGCCCGGCAAAGCCGGTTCTGCGGCGCCTGC
TGGCGTGGCCTGCTCCGCGG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSNPQVELHIAGHGVIVLELDADKAPKSTENFLAYVKKGHYDNTIFHRVIPGFMIQGGGFEPGMNQKGTDAPIENEAQNG
LKNDKYTVAMARTSDPHSATAQFFINVADNGFLNHTAPSAQGWGYAVFGKVVKGTEIVDAIKGVKTGRKGFHDDVPKDDV
IIEKAVVA

Sequences:

>Translated_168_residues
MSNPQVELHIAGHGVIVLELDADKAPKSTENFLAYVKKGHYDNTIFHRVIPGFMIQGGGFEPGMNQKGTDAPIENEAQNG
LKNDKYTVAMARTSDPHSATAQFFINVADNGFLNHTAPSAQGWGYAVFGKVVKGTEIVDAIKGVKTGRKGFHDDVPKDDV
IIEKAVVA
>Mature_167_residues
SNPQVELHIAGHGVIVLELDADKAPKSTENFLAYVKKGHYDNTIFHRVIPGFMIQGGGFEPGMNQKGTDAPIENEAQNGL
KNDKYTVAMARTSDPHSATAQFFINVADNGFLNHTAPSAQGWGYAVFGKVVKGTEIVDAIKGVKTGRKGFHDDVPKDDVI
IEKAVVA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=167, Percent_Identity=34.1317365269461, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=31.7073170731707, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=31.7073170731707, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI24308049, Length=144, Percent_Identity=34.7222222222222, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI19557636, Length=158, Percent_Identity=30.379746835443, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=31.7073170731707, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI64276486, Length=127, Percent_Identity=36.2204724409449, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310110104, Length=157, Percent_Identity=35.031847133758, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI10863927, Length=151, Percent_Identity=36.4238410596026, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310129267, Length=157, Percent_Identity=33.7579617834395, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI310120620, Length=157, Percent_Identity=33.7579617834395, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=156, Percent_Identity=66.025641025641, Blast_Score=217, Evalue=4e-58,
Organism=Escherichia coli, GI1789763, Length=165, Percent_Identity=55.7575757575758, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71980594, Length=148, Percent_Identity=35.1351351351351, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=148, Percent_Identity=35.1351351351351, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=161, Percent_Identity=31.055900621118, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17566266, Length=180, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=149, Percent_Identity=31.5436241610738, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=156, Percent_Identity=30.1282051282051, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=146, Percent_Identity=34.9315068493151, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551284, Length=146, Percent_Identity=34.9315068493151, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19922912, Length=162, Percent_Identity=35.8024691358025, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17986117, Length=159, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664125, Length=180, Percent_Identity=35, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357783, Length=180, Percent_Identity=35, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19922376, Length=160, Percent_Identity=29.375, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17647301, Length=170, Percent_Identity=34.1176470588235, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18121; Mature: 17989

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPQVELHIAGHGVIVLELDADKAPKSTENFLAYVKKGHYDNTIFHRVIPGFMIQGGGF
CCCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEECCCC
EPGMNQKGTDAPIENEAQNGLKNDKYTVAMARTSDPHSATAQFFINVADNGFLNHTAPSA
CCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCC
QGWGYAVFGKVVKGTEIVDAIKGVKTGRKGFHDDVPKDDVIIEKAVVA
CCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHEECC
>Mature Secondary Structure 
SNPQVELHIAGHGVIVLELDADKAPKSTENFLAYVKKGHYDNTIFHRVIPGFMIQGGGF
CCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEECCCC
EPGMNQKGTDAPIENEAQNGLKNDKYTVAMARTSDPHSATAQFFINVADNGFLNHTAPSA
CCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCC
QGWGYAVFGKVVKGTEIVDAIKGVKTGRKGFHDDVPKDDVIIEKAVVA
CCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]