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The map label for this gene is cyp18 [H]

Identifier: 120610989

GI number: 120610989

Start: 2544953

End: 2545546

Strand: Reverse

Name: cyp18 [H]

Synonym: Aave_2317

Alternate gene names: 120610989

Gene position: 2545546-2544953 (Counterclockwise)

Preceding gene: 120610990

Following gene: 120610988

Centisome position: 47.56

GC content: 67.17

Gene sequence:

>594_bases
ATGACGACCCTGATTTCCAGACGATTCGCCGCCCTGGCGCTGGCCGGCGCCGCGTTCGCGGCGCTCGCGCCCGCCGCCTC
CGCGCAGACCGCCGCGGCCGCGCCGAAGGTCAGGCTGGCGACCAGCCTGGGCGACATCGTGCTGCAGCTCGATCCCGCCA
AGGCACCGAAGACGGTCGAGAACTTCCTGCAGTACGTGAAGGACAAGCACTACGATGGCACGATCTTCCACCGCGTCATC
GACGGCTTCATGATCCAGGGCGGCGGCTTCACGCCCGGCATGCAGCAGAAACCCACGCGCGCCCCGATTCCGCTGGAAGC
GGGCAACGGCTTGAAGAACGATGCCTACACCATCGCCATGGCGCGCACCGGCAACCCCGATTCGGCCACCTCGCAGTTCT
TCATCAACGTGAAGGACAACGCCGCGCTGAACGCGCCCAACCCCGACGGCCACGGCTACGCCGTGTTCGGCAAGGTCGTG
AGCGGCAAGGAGGTGGTGGACAAGATCAAGGCGGTGGAGACCGCCAGCCGCGGCATGCACCAGAACGTGCCCGCGACGCC
GGTCGTGATCAAATCCGCCACCGTGGTGCAGTGA

Upstream 100 bases:

>100_bases
TCGGCGAAGTCGCCGAAGGGGCCCGCACCGGCCCCGTCAAGCGCCAGTACTGGACGCGCAAGGGCCAGCAATGGCAGATA
TTTTTCGAAGGAGTGATTGG

Downstream 100 bases:

>100_bases
GCCACCCTCGCCCGCATCTGCAACATCCCCACCCGGGATCCCCATAAGGAAACGCAATGAGCAACCCGCAAGTCGAACTC
CATATCGCCGGCCACGGCGT

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTTLISRRFAALALAGAAFAALAPAASAQTAAAAPKVRLATSLGDIVLQLDPAKAPKTVENFLQYVKDKHYDGTIFHRVI
DGFMIQGGGFTPGMQQKPTRAPIPLEAGNGLKNDAYTIAMARTGNPDSATSQFFINVKDNAALNAPNPDGHGYAVFGKVV
SGKEVVDKIKAVETASRGMHQNVPATPVVIKSATVVQ

Sequences:

>Translated_197_residues
MTTLISRRFAALALAGAAFAALAPAASAQTAAAAPKVRLATSLGDIVLQLDPAKAPKTVENFLQYVKDKHYDGTIFHRVI
DGFMIQGGGFTPGMQQKPTRAPIPLEAGNGLKNDAYTIAMARTGNPDSATSQFFINVKDNAALNAPNPDGHGYAVFGKVV
SGKEVVDKIKAVETASRGMHQNVPATPVVIKSATVVQ
>Mature_196_residues
TTLISRRFAALALAGAAFAALAPAASAQTAAAAPKVRLATSLGDIVLQLDPAKAPKTVENFLQYVKDKHYDGTIFHRVID
GFMIQGGGFTPGMQQKPTRAPIPLEAGNGLKNDAYTIAMARTGNPDSATSQFFINVKDNAALNAPNPDGHGYAVFGKVVS
GKEVVDKIKAVETASRGMHQNVPATPVVIKSATVVQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=154, Percent_Identity=38.3116883116883, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706339, Length=152, Percent_Identity=36.1842105263158, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI22547212, Length=168, Percent_Identity=33.9285714285714, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7657473, Length=168, Percent_Identity=33.9285714285714, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI22547215, Length=168, Percent_Identity=33.9285714285714, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI19557636, Length=162, Percent_Identity=32.7160493827161, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4758950, Length=205, Percent_Identity=31.7073170731707, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI64276486, Length=164, Percent_Identity=34.7560975609756, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI42560244, Length=145, Percent_Identity=34.4827586206897, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI1789763, Length=189, Percent_Identity=58.2010582010582, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=57.6687116564417, Blast_Score=184, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=144, Percent_Identity=35.4166666666667, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=35.4166666666667, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=144, Percent_Identity=36.1111111111111, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551282, Length=172, Percent_Identity=33.7209302325581, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=172, Percent_Identity=33.7209302325581, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=154, Percent_Identity=33.1168831168831, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=150, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=202, Percent_Identity=32.6732673267327, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=33.5365853658537, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922912, Length=136, Percent_Identity=41.9117647058824, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=27.3809523809524, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20615; Mature: 20484

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLISRRFAALALAGAAFAALAPAASAQTAAAAPKVRLATSLGDIVLQLDPAKAPKTVE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEHCCCCCEEEEECCCCCCHHHH
NFLQYVKDKHYDGTIFHRVIDGFMIQGGGFTPGMQQKPTRAPIPLEAGNGLKNDAYTIAM
HHHHHHHCCCCCCHHHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
ARTGNPDSATSQFFINVKDNAALNAPNPDGHGYAVFGKVVSGKEVVDKIKAVETASRGMH
EECCCCCCCCCEEEEEECCCCEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCC
QNVPATPVVIKSATVVQ
CCCCCCCEEEECEEECC
>Mature Secondary Structure 
TTLISRRFAALALAGAAFAALAPAASAQTAAAAPKVRLATSLGDIVLQLDPAKAPKTVE
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEHCCCCCEEEEECCCCCCHHHH
NFLQYVKDKHYDGTIFHRVIDGFMIQGGGFTPGMQQKPTRAPIPLEAGNGLKNDAYTIAM
HHHHHHHCCCCCCHHHHHHHHCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
ARTGNPDSATSQFFINVKDNAALNAPNPDGHGYAVFGKVVSGKEVVDKIKAVETASRGMH
EECCCCCCCCCEEEEEECCCCEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCC
QNVPATPVVIKSATVVQ
CCCCCCCEEEECEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]