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The map label for this gene is lpxH [H]

Identifier: 120610987

GI number: 120610987

Start: 2543420

End: 2544253

Strand: Reverse

Name: lpxH [H]

Synonym: Aave_2315

Alternate gene names: 120610987

Gene position: 2544253-2543420 (Counterclockwise)

Preceding gene: 120610988

Following gene: 120610986

Centisome position: 47.53

GC content: 71.22

Gene sequence:

>834_bases
ATGAGCCTGGCGCAAGCGCACTCCTGCTCCCGTATGGTCATGAGCATGCCTGCACCCGACATCCGGGAGTTCGTTGCGCC
CGGCGCGTGGCGCACGGTGGATTTCATTTCCGACCTGCACCTGGAGGCGGACCACCCGGCCACGGTGGAGGCTTTCTCGC
ATTACCTGGACACGACGTCCGCCGACGCCGTGTTCCTGCTGGGCGACCTGTTCGAGGTCTGGGTGGGCGACGACGCGATC
CAGGAGGCCGGCAGCTTCGAGGCCGCGTGCTGCGCGGTGCTGCGCCGCGCCGCGTCCCGCAGGGCGCTGTACTTCATGCA
CGGCAACCGCGATTTCCTGGTAGGTGCCGGGTTCACGGAAGCCACGGGCATCCCCGTGCTGCAGGACCCCACGGTGCTGG
TCTTCGCTGGCGGCCGCTGGCTCCTGAGCCATGGCGATGCGCTGTGCCTCGCGGACCTGCCCTACCAGAAATTCCGCGCC
ATGGCGCGCGACCCGCAATGGCAGGCGCAACTGCTCGCGCTGCCGCTGGCCGCGCGCCGCGCCCAGGGCCGCAGCGCGCG
CGCCGAGAGCGAATCCCGCAAGCAGTCGGGCACCGCCTTCTACGGCGACGTGGACAATGCCGCGGCCGTGCAATGGCTGC
AGGCCGCGCAGGCGCGCGCCCTGATCCACGGCCACACCCACCTGCCCGCCGACCACGTGCTGCAGGGGGACGGCGACACC
GCCCTCGCCCGCCACGTGCTCACCGACTGGGACCTGTCCGCACGGACGCCGCGCGCTGAGGCACTGCGCCTCACGGCCGC
GGGCTTGGAACGCATCAGCCTCGTCCCCAGATAG

Upstream 100 bases:

>100_bases
GGACGACGCCGGCAGCCCGGCAAAGCCGGTTCTGCGGCGCCTGCTGGCGTGGCCTGCTCCGCGGCCTTCCGACCGCGGGC
GCCGCGCGGGTGAGAGGGCC

Downstream 100 bases:

>100_bases
CGGCATGGCCCCTGCCTCCGCTTTCACGCGCCTGGTGCGCAAGCTCTCCCGGCGCGTGCGCTCGACGATCGCCCCGGTTC
CCGACATTCCCGCCGCGCTG

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSLAQAHSCSRMVMSMPAPDIREFVAPGAWRTVDFISDLHLEADHPATVEAFSHYLDTTSADAVFLLGDLFEVWVGDDAI
QEAGSFEAACCAVLRRAASRRALYFMHGNRDFLVGAGFTEATGIPVLQDPTVLVFAGGRWLLSHGDALCLADLPYQKFRA
MARDPQWQAQLLALPLAARRAQGRSARAESESRKQSGTAFYGDVDNAAAVQWLQAAQARALIHGHTHLPADHVLQGDGDT
ALARHVLTDWDLSARTPRAEALRLTAAGLERISLVPR

Sequences:

>Translated_277_residues
MSLAQAHSCSRMVMSMPAPDIREFVAPGAWRTVDFISDLHLEADHPATVEAFSHYLDTTSADAVFLLGDLFEVWVGDDAI
QEAGSFEAACCAVLRRAASRRALYFMHGNRDFLVGAGFTEATGIPVLQDPTVLVFAGGRWLLSHGDALCLADLPYQKFRA
MARDPQWQAQLLALPLAARRAQGRSARAESESRKQSGTAFYGDVDNAAAVQWLQAAQARALIHGHTHLPADHVLQGDGDT
ALARHVLTDWDLSARTPRAEALRLTAAGLERISLVPR
>Mature_276_residues
SLAQAHSCSRMVMSMPAPDIREFVAPGAWRTVDFISDLHLEADHPATVEAFSHYLDTTSADAVFLLGDLFEVWVGDDAIQ
EAGSFEAACCAVLRRAASRRALYFMHGNRDFLVGAGFTEATGIPVLQDPTVLVFAGGRWLLSHGDALCLADLPYQKFRAM
ARDPQWQAQLLALPLAARRAQGRSARAESESRKQSGTAFYGDVDNAAAVQWLQAAQARALIHGHTHLPADHVLQGDGDTA
LARHVLTDWDLSARTPRAEALRLTAAGLERISLVPR

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=218, Percent_Identity=40.8256880733945, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 30139; Mature: 30008

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAQAHSCSRMVMSMPAPDIREFVAPGAWRTVDFISDLHLEADHPATVEAFSHYLDTTS
CCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
ADAVFLLGDLFEVWVGDDAIQEAGSFEAACCAVLRRAASRRALYFMHGNRDFLVGAGFTE
CCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCH
ATGIPVLQDPTVLVFAGGRWLLSHGDALCLADLPYQKFRAMARDPQWQAQLLALPLAARR
HCCCCEECCCEEEEEECCEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHH
AQGRSARAESESRKQSGTAFYGDVDNAAAVQWLQAAQARALIHGHTHLPADHVLQGDGDT
HCCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCH
ALARHVLTDWDLSARTPRAEALRLTAAGLERISLVPR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLAQAHSCSRMVMSMPAPDIREFVAPGAWRTVDFISDLHLEADHPATVEAFSHYLDTTS
CCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
ADAVFLLGDLFEVWVGDDAIQEAGSFEAACCAVLRRAASRRALYFMHGNRDFLVGAGFTE
CCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCH
ATGIPVLQDPTVLVFAGGRWLLSHGDALCLADLPYQKFRAMARDPQWQAQLLALPLAARR
HCCCCEECCCEEEEEECCEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHH
AQGRSARAESESRKQSGTAFYGDVDNAAAVQWLQAAQARALIHGHTHLPADHVLQGDGDT
HCCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHEEECCCCH
ALARHVLTDWDLSARTPRAEALRLTAAGLERISLVPR
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]