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The map label for this gene is fabI1 [H]

Identifier: 120610730

GI number: 120610730

Start: 2244087

End: 2244857

Strand: Direct

Name: fabI1 [H]

Synonym: Aave_2051

Alternate gene names: 120610730

Gene position: 2244087-2244857 (Clockwise)

Preceding gene: 120610729

Following gene: 120610738

Centisome position: 41.92

GC content: 69.91

Gene sequence:

>771_bases
ATGCCTTTACTGGACCTGCACGGCAAGCGCGGATTGGTCGTCGGCATCGCCAATGACCAGAGCATCGCCTGGGGCTGTGC
CCGCGCCTTCCGCGATGCGGGGGCGGAACTGGCGGTCACCTGGCTCAACGACAAGGCCCGGGCGTATGTGGAGCCGCTGG
CGCGGCAGGTGGATGCGCCGATCACGCTGCCGCTGGACGTGGAGCAGCCCGGCCAGATGGAGGCGGTATTCGGTGCCGTC
GCCCGCGAATGGGGGCGCCTGGATTTCGTGCTGCATTCCATCGCCTTCGCGCCGCGCAGCGATCTTTCCGGGCGCGTGAC
CGACAGCTCGCGCGAGGGTTTCGCGCGGGCGATGGATATTTCCTGCCATTCCTTCCTGCGCATGGCCCGGCTGGCCGAGC
CGCTGATGCCGCAGGGCGGCAGCCTGATGACGATGAGCTACGTCGGCGCGGCCGAGGTGATTCCCGGCTATGGCGTGATG
GGGCCGGTGAAGGCAGCGCTGGAATCCGGCACGCGCTACCTGGCCGCGGAACTGGGGCCGAAGGGGATCCGCGTCAACGC
GGTCTCCCCCGGGCCGCTGGCCACGCGGGCGGCCTCCGGCATTCCCGACTTCGACACGCTCATGGCGGATGCCGTGCGGC
GGGCACCGCTGCGCCGCCTGGTGGAGCTGGAGGAGATCGGCGCGCTGTGCGCCTTCCTGGCCAGCGACGGTGCGCGGGCC
ATCACCGGCAATACGCTGTACGTGGATGCGGGCCACCATATCCTGGGCTGA

Upstream 100 bases:

>100_bases
CCGCGAGGCCGGGGAGCATTCCGCAAGCCTTGGTGGCCGCGCTGGCCTTCCTTTTCCTCTCTTTTCTTCCTTTCCTCAAC
CTGCCCACCCGGGAGTTCCC

Downstream 100 bases:

>100_bases
CAGGGCCGGCGGGCGGCCGGCTGGCGTGGCGTTCCAACGGTGCCGGGGGGGCCGGCGTGCCGGCCGCGGGCGCGCGCCGG
GCGCGGATCAGCCCGGCTGC

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MPLLDLHGKRGLVVGIANDQSIAWGCARAFRDAGAELAVTWLNDKARAYVEPLARQVDAPITLPLDVEQPGQMEAVFGAV
AREWGRLDFVLHSIAFAPRSDLSGRVTDSSREGFARAMDISCHSFLRMARLAEPLMPQGGSLMTMSYVGAAEVIPGYGVM
GPVKAALESGTRYLAAELGPKGIRVNAVSPGPLATRAASGIPDFDTLMADAVRRAPLRRLVELEEIGALCAFLASDGARA
ITGNTLYVDAGHHILG

Sequences:

>Translated_256_residues
MPLLDLHGKRGLVVGIANDQSIAWGCARAFRDAGAELAVTWLNDKARAYVEPLARQVDAPITLPLDVEQPGQMEAVFGAV
AREWGRLDFVLHSIAFAPRSDLSGRVTDSSREGFARAMDISCHSFLRMARLAEPLMPQGGSLMTMSYVGAAEVIPGYGVM
GPVKAALESGTRYLAAELGPKGIRVNAVSPGPLATRAASGIPDFDTLMADAVRRAPLRRLVELEEIGALCAFLASDGARA
ITGNTLYVDAGHHILG
>Mature_255_residues
PLLDLHGKRGLVVGIANDQSIAWGCARAFRDAGAELAVTWLNDKARAYVEPLARQVDAPITLPLDVEQPGQMEAVFGAVA
REWGRLDFVLHSIAFAPRSDLSGRVTDSSREGFARAMDISCHSFLRMARLAEPLMPQGGSLMTMSYVGAAEVIPGYGVMG
PVKAALESGTRYLAAELGPKGIRVNAVSPGPLATRAASGIPDFDTLMADAVRRAPLRRLVELEEIGALCAFLASDGARAI
TGNTLYVDAGHHILG

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=28.8135593220339, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI66933014, Length=232, Percent_Identity=28.0172413793103, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI32483357, Length=172, Percent_Identity=30.2325581395349, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=25.8964143426295, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI10190704, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI4503301, Length=222, Percent_Identity=27.027027027027, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1787545, Length=250, Percent_Identity=44, Blast_Score=214, Evalue=5e-57,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=27.5193798449612, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789378, Length=262, Percent_Identity=24.8091603053435, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=28.75, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787335, Length=195, Percent_Identity=28.7179487179487, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=25.296442687747, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=244, Percent_Identity=25.8196721311475, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=115, Percent_Identity=39.1304347826087, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=268, Percent_Identity=26.1194029850746, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=265, Percent_Identity=26.0377358490566, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=216, Percent_Identity=26.3888888888889, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28571526, Length=199, Percent_Identity=30.6532663316583, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=239, Percent_Identity=28.8702928870293, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24644339, Length=259, Percent_Identity=25.8687258687259, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644337, Length=202, Percent_Identity=28.7128712871287, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=24.0963855421687, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=25.1336898395722, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24643142, Length=145, Percent_Identity=24.1379310344828, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 27179; Mature: 27047

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLDLHGKRGLVVGIANDQSIAWGCARAFRDAGAELAVTWLNDKARAYVEPLARQVDAP
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCC
ITLPLDVEQPGQMEAVFGAVAREWGRLDFVLHSIAFAPRSDLSGRVTDSSREGFARAMDI
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
SCHSFLRMARLAEPLMPQGGSLMTMSYVGAAEVIPGYGVMGPVKAALESGTRYLAAELGP
HHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHCCCEEEEECCCC
KGIRVNAVSPGPLATRAASGIPDFDTLMADAVRRAPLRRLVELEEIGALCAFLASDGARA
CCEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ITGNTLYVDAGHHILG
EECCEEEEECCCCCCC
>Mature Secondary Structure 
PLLDLHGKRGLVVGIANDQSIAWGCARAFRDAGAELAVTWLNDKARAYVEPLARQVDAP
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCC
ITLPLDVEQPGQMEAVFGAVAREWGRLDFVLHSIAFAPRSDLSGRVTDSSREGFARAMDI
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
SCHSFLRMARLAEPLMPQGGSLMTMSYVGAAEVIPGYGVMGPVKAALESGTRYLAAELGP
HHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHCCCEEEEECCCC
KGIRVNAVSPGPLATRAASGIPDFDTLMADAVRRAPLRRLVELEEIGALCAFLASDGARA
CCEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ITGNTLYVDAGHHILG
EECCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]