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The map label for this gene is nuoN [H]

Identifier: 120609963

GI number: 120609963

Start: 1400945

End: 1402438

Strand: Direct

Name: nuoN [H]

Synonym: Aave_1276

Alternate gene names: 120609963

Gene position: 1400945-1402438 (Clockwise)

Preceding gene: 120609962

Following gene: 120609964

Centisome position: 26.17

GC content: 66.27

Gene sequence:

>1494_bases
ATGATTGACAACATCAGCTGGCTGGCGGTGTACCCGGAGATCGTGCTCCTGGTGATGGCCTGCGTGATCGCCCTGGTGGA
CCTGGGCGTGACGAGCGCCCGTCGCACCGGCACCTACGTGCTCACCATGCTCACCCTGGCCGTGGTGGCCGTGCTGCAGG
GCATGTACGCGAGCAGCGGCAACACGTTCTACGGCTTCGGCAACATGGTGGTGAGCGACGCCATGGGCAACTGGCTCAAG
TGCTTCGCGACCATCGCCGTGATGGTGACGCTGGTCTATGGCCGGCCCTATGCGGCGGACCGCGGCATGCTGCGCGGCGG
CGAGCTGTTCACGCTCTCGATGTTCATGCTGCTGGGCGTGTTCGTCATGGTGTCGGGCAACAACTTCCTCGTGATCTACC
TGGGCCTGGAACTGCTCACGCTCTCCAGCTACGCGCTGGTGGCGCTGCGCCGCGACCACACGACCGCCACCGAAGCCGCC
ATGAAGTACTTCGTGCTCGGCGCGATGGCGAGCGGCTTCCTGCTCTACGGCCTCTCGATGCTCTACGGCGCCACCGGCTC
GCTCGACATCGGCCAGGTCTTCAAGGCCGTGAATTCGGGCCAGATCCGCCACCAGGTGCTGGTGTTCGGACTCGTGTTCG
TCGTGGCCGGCCTCGCGTTCAAGATCGGCGCCGTGCCGTTCCACATGTGGATTCCGGACGTGTACCAGGGTGCCCCGACG
GCCGTGACGGTCATCATCGGCAGCGCGCCCAAGCTGGCCGCCTTCGCGATCATGATCCGCCTGCTGGTCGATGGCCTGCT
GCCGCTGGCCATCGACTGGCAGCAGATGCTGGCCGTGCTGGCGATCGGCTCGCTGCTGGTGGGCAACCTGGCGGCCATCG
CGCAGACGAACCTGAAGCGGATGCTGGCGTACTCCACCATCGCGCAGATGGGCTTCGTGCTGCTGGGCCTGCTGTCGGGT
GTCATCAATGGCAACGTGGATGCGAACGCGGTCGAGAACGCCTACAGCTCGGCGATGTTCTACATCCTGACCTACGTGCT
GACCACGCTGGCGAGCTTCGGCATCATCCTGCTGCTGGCGCGCGAAGGCTTCGAAAGCGAAGAGATCTCCGACCTGGCCG
GCCTGAACCAGCGCAGCCCGCTCTACGCCGGCGTGATGGCCGTCTGCCTGTTCTCGCTGGCGGGCATCCCCCCGATGGTG
GGCTTCTACGCCAAGCTCGCCGTGCTGCAGGCCCTGGTGGCTTCCGGCCAGGCCCCGTACATCGCGCTGGCCGTGTTCGC
CGTCGTGATGTCGCTGATCGGCGCGTTCTACTACCTGCGCGTCGTGAAGGTGATGTACTTCGATGCACCGCTGACGGCCA
CCAGCGTGTCCGCGCCGCTCGACGTGCGCATGGTCTTGACGGTGAACGGCGCCCTGGTGCTGGTCCTCGGCCTCGTGCCG
GGCGGCCTGATGGCACTGTGTGCCGACGCGGTGGTGCGCGCACTGGCCACCTGA

Upstream 100 bases:

>100_bases
GCGCCCCTTCACCGACGTGATGGACGTGTCGGTGGCCGAGCTGCTCAAGCACGTGGCGCAGACCAAGCTCCATTGAACCG
ACTGACAACGAGAGACCGAG

Downstream 100 bases:

>100_bases
ACGACCGTTTGCGGAGGCCGGCCGCCATTCCCGCTCCATCGCGCTCCGCCACCACGCGGGCGCGGCGGTGGAGAGAGGGG
AAGGGCGCTGCCTCCGGACC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MIDNISWLAVYPEIVLLVMACVIALVDLGVTSARRTGTYVLTMLTLAVVAVLQGMYASSGNTFYGFGNMVVSDAMGNWLK
CFATIAVMVTLVYGRPYAADRGMLRGGELFTLSMFMLLGVFVMVSGNNFLVIYLGLELLTLSSYALVALRRDHTTATEAA
MKYFVLGAMASGFLLYGLSMLYGATGSLDIGQVFKAVNSGQIRHQVLVFGLVFVVAGLAFKIGAVPFHMWIPDVYQGAPT
AVTVIIGSAPKLAAFAIMIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIAQTNLKRMLAYSTIAQMGFVLLGLLSG
VINGNVDANAVENAYSSAMFYILTYVLTTLASFGIILLLAREGFESEEISDLAGLNQRSPLYAGVMAVCLFSLAGIPPMV
GFYAKLAVLQALVASGQAPYIALAVFAVVMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRMVLTVNGALVLVLGLVP
GGLMALCADAVVRALAT

Sequences:

>Translated_497_residues
MIDNISWLAVYPEIVLLVMACVIALVDLGVTSARRTGTYVLTMLTLAVVAVLQGMYASSGNTFYGFGNMVVSDAMGNWLK
CFATIAVMVTLVYGRPYAADRGMLRGGELFTLSMFMLLGVFVMVSGNNFLVIYLGLELLTLSSYALVALRRDHTTATEAA
MKYFVLGAMASGFLLYGLSMLYGATGSLDIGQVFKAVNSGQIRHQVLVFGLVFVVAGLAFKIGAVPFHMWIPDVYQGAPT
AVTVIIGSAPKLAAFAIMIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIAQTNLKRMLAYSTIAQMGFVLLGLLSG
VINGNVDANAVENAYSSAMFYILTYVLTTLASFGIILLLAREGFESEEISDLAGLNQRSPLYAGVMAVCLFSLAGIPPMV
GFYAKLAVLQALVASGQAPYIALAVFAVVMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRMVLTVNGALVLVLGLVP
GGLMALCADAVVRALAT
>Mature_497_residues
MIDNISWLAVYPEIVLLVMACVIALVDLGVTSARRTGTYVLTMLTLAVVAVLQGMYASSGNTFYGFGNMVVSDAMGNWLK
CFATIAVMVTLVYGRPYAADRGMLRGGELFTLSMFMLLGVFVMVSGNNFLVIYLGLELLTLSSYALVALRRDHTTATEAA
MKYFVLGAMASGFLLYGLSMLYGATGSLDIGQVFKAVNSGQIRHQVLVFGLVFVVAGLAFKIGAVPFHMWIPDVYQGAPT
AVTVIIGSAPKLAAFAIMIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIAQTNLKRMLAYSTIAQMGFVLLGLLSG
VINGNVDANAVENAYSSAMFYILTYVLTTLASFGIILLLAREGFESEEISDLAGLNQRSPLYAGVMAVCLFSLAGIPPMV
GFYAKLAVLQALVASGQAPYIALAVFAVVMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRMVLTVNGALVLVLGLVP
GGLMALCADAVVRALAT

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=329, Percent_Identity=23.7082066869301, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI145693160, Length=387, Percent_Identity=33.8501291989664, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788614, Length=387, Percent_Identity=27.1317829457364, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788827, Length=352, Percent_Identity=26.7045454545455, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788831, Length=319, Percent_Identity=25.3918495297806, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI2367154, Length=320, Percent_Identity=24.0625, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788829, Length=339, Percent_Identity=25.9587020648968, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788613, Length=216, Percent_Identity=27.7777777777778, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52699; Mature: 52699

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNISWLAVYPEIVLLVMACVIALVDLGVTSARRTGTYVLTMLTLAVVAVLQGMYASSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
NTFYGFGNMVVSDAMGNWLKCFATIAVMVTLVYGRPYAADRGMLRGGELFTLSMFMLLGV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
FVMVSGNNFLVIYLGLELLTLSSYALVALRRDHTTATEAAMKYFVLGAMASGFLLYGLSM
HHHCCCCCEEEEEEHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGATGSLDIGQVFKAVNSGQIRHQVLVFGLVFVVAGLAFKIGAVPFHMWIPDVYQGAPT
HHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHCCCCC
AVTVIIGSAPKLAAFAIMIRLLVDGLLPLAIDWQQMLAVLAIGSLLVGNLAAIAQTNLKR
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLAYSTIAQMGFVLLGLLSGVINGNVDANAVENAYSSAMFYILTYVLTTLASFGIILLLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REGFESEEISDLAGLNQRSPLYAGVMAVCLFSLAGIPPMVGFYAKLAVLQALVASGQAPY
HCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCH
IALAVFAVVMSLIGAFYYLRVVKVMYFDAPLTATSVSAPLDVRMVLTVNGALVLVLGLVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHCC
GGLMALCADAVVRALAT
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA