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The map label for this gene is nuoL [H]

Identifier: 120609961

GI number: 120609961

Start: 1397395

End: 1399431

Strand: Direct

Name: nuoL [H]

Synonym: Aave_1274

Alternate gene names: 120609961

Gene position: 1397395-1399431 (Clockwise)

Preceding gene: 120609960

Following gene: 120609962

Centisome position: 26.11

GC content: 64.16

Gene sequence:

>2037_bases
ATGAGTCAAACCCTCTCCGCTTCGATGCTCCTCGCGGTGCCGCTGGCGCCGCTGGCGGGCTCCGCGCTCGCCGGCATCCT
CGGCACGGCCTTCGGCGGCAACCGCATCGGACGCCGCGCGAGCCACACCCTCACGATCCTCGGCGTGTTCGTCGCGTTCG
TGCTCTCGGCCCTGACGTTCAAGAGCGTGGCGCTCGACGGTGCCCGTTTCAACGAGACGCTCTACACCTGGATGGTGGTG
GGCGGCCTCAAGATGGAAGTCGGCTTCCTCGTCGACACGCTCACCGCCATGATGATGTGCGTGGTGACCTTCGTGTCGCT
GATGGTGCACATCTACACCATCGGCTACATGGAAGAGGACGACGGCTACAACCGCTTCTTCTCGTACATCTCGCTGTTCA
CGTTCTCGATGCTCATGCTGGTCATGAGCAACAACCTGCTGCAGCTGTTCTTCGGCTGGGAAGCGGTGGGCCTCGTGTCG
TACCTGCTGATCGGCTTCTGGTTCAACAAGCCCACGGCCATCTTCGCCAACATGAAGGCGTTCCTGGTGAACCGCGTCGG
CGACTTCGGCTTCATCCTGGGCATCGGCCTGATCGCCGCCTACACCGGCACGCTGAACTACGGCGAGATCTTCGCCAGGT
CGGGCGAGCTCGGCACCATCGGCTTCCCCGGCACCGACTGGATGCTCATCACCGTGATCTGCATCTGCCTGTTCATCGGC
GCGATGGGCAAGAGCGCGCAGTTCCCGCTGCACGTGTGGCTGCCCGACTCGATGGAAGGCCCGACCCCGATCTCCGCGCT
GATCCACGCGGCCACCATGGTGACCGCCGGCATCTTCATGGTGTCGCGCATGTCGCCGCTGTTCGAGCTGTCGGACACGG
CCCTCAACTTCATCCTGGTGATCGGCGCCATCACGGCCCTGTTCATGGGCTTCCTGGGCATGATCCAGAACGACATCAAG
CGCGTGGTGGCCTATTCCACGCTGTCGCAGCTGGGCTACATGACCGTGGCACTGGGTGCTTCCGCCTACTCGGTGGCCGT
GTTCCACCTGATGACGCACGCGTTCTTCAAGGCGCTTCTGTTCCTCGGCGCGGGTTCGGTGATCATGGGCATGCACCACA
ACCAGGACATCCGCTGGATGGGGGCCGTCCGCAAGTACATGCCCATCACCTGGATCACCTCGCTGCTGGGTTCCCTGGCG
CTGATCGGCATGCCGCTGTTCTCGGGCTTCTATTCCAAGGACAGCATCATCGAGGCCGTGCACGCCAGCACGCTGCCGGC
CGCGGGCTTCGCGCACTTCGCCGTGCTGGCCGGCGTGTTCGTGACAGCGTTCTATTCGTTCCGCATGTACTTCCTCGTCT
TCCACGGCAAGGAGCGCTACGACCAGAACCCGGACGCGCACCACGACGACCACCATGCGCACGACGACCACGGCCACGGC
CATGGCCACGACGCCAAGCCGCACGAGTCGCCCTGGGTGGTGACGGTGCCCCTGGTGCTGCTGGCGATCCCCTCGGTGGT
GATCGGCTTCCTGGCCATCCAGCCGATGCTGTTCGGCGACTTCTTCAAGGACGTGATCTTCGTGGATGCCGCCAAGCACC
CCGCGATGGCCGAGCTGTCGGAGATGTTCCACGGCCCGGTGGCGATGGCCCTGCACGGCCTGCAGGCGGCGCCGTTCTGG
CTGGCCCTGGCCGGCGTCGCGCTCTCCTACTACATGTACATGGTCAACCCGGCCCTGCCGGCGGCGATCAAGCGCGCCTG
CATGCCGATCTACACCCTGTTCGAGAACAAGTACTACCTCGACTGGATCAACGAGAACATCATCGCCCGCGGTGCCCGCG
CATTGGGAACGGGCCTGTGGAAGGGTGGCGACCAGGCCGTGATCGATGGCGCCGTGGTGAACGGTTCCTGGAAGGTCGTG
GGCTGGGTCGCAGGCATCGTGCGCTGGGTGCAGTCGGGCTACATCTACCACTATGCGCTGGTGATGATCCTGGGCGTGTT
CGGGCTCATGACGTACTTCGTGTGGCTCAACAAGTAG

Upstream 100 bases:

>100_bases
GCGATCCTGGTGCTGCTGTTCCGCAACAAGTCCAGCATCGACGCGGAAGATCTCAACACCCTCAAGGGCTGATCCGCCGG
TACTTGCAAGGTCTTCAAGA

Downstream 100 bases:

>100_bases
AGGAACAAGAAAAATGGGTTTGTTGAGTCTTGCCATCTGGACGCCGATCGCCTTCGGTGCCCTGCTGCTGGCCTTCGGGC
GCGACGATCAGGCGCGCGCC

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MSQTLSASMLLAVPLAPLAGSALAGILGTAFGGNRIGRRASHTLTILGVFVAFVLSALTFKSVALDGARFNETLYTWMVV
GGLKMEVGFLVDTLTAMMMCVVTFVSLMVHIYTIGYMEEDDGYNRFFSYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVS
YLLIGFWFNKPTAIFANMKAFLVNRVGDFGFILGIGLIAAYTGTLNYGEIFARSGELGTIGFPGTDWMLITVICICLFIG
AMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILVIGAITALFMGFLGMIQNDIK
RVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIMGMHHNQDIRWMGAVRKYMPITWITSLLGSLA
LIGMPLFSGFYSKDSIIEAVHASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHDDHHAHDDHGHG
HGHDAKPHESPWVVTVPLVLLAIPSVVIGFLAIQPMLFGDFFKDVIFVDAAKHPAMAELSEMFHGPVAMALHGLQAAPFW
LALAGVALSYYMYMVNPALPAAIKRACMPIYTLFENKYYLDWINENIIARGARALGTGLWKGGDQAVIDGAVVNGSWKVV
GWVAGIVRWVQSGYIYHYALVMILGVFGLMTYFVWLNK

Sequences:

>Translated_678_residues
MSQTLSASMLLAVPLAPLAGSALAGILGTAFGGNRIGRRASHTLTILGVFVAFVLSALTFKSVALDGARFNETLYTWMVV
GGLKMEVGFLVDTLTAMMMCVVTFVSLMVHIYTIGYMEEDDGYNRFFSYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVS
YLLIGFWFNKPTAIFANMKAFLVNRVGDFGFILGIGLIAAYTGTLNYGEIFARSGELGTIGFPGTDWMLITVICICLFIG
AMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILVIGAITALFMGFLGMIQNDIK
RVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIMGMHHNQDIRWMGAVRKYMPITWITSLLGSLA
LIGMPLFSGFYSKDSIIEAVHASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHDDHHAHDDHGHG
HGHDAKPHESPWVVTVPLVLLAIPSVVIGFLAIQPMLFGDFFKDVIFVDAAKHPAMAELSEMFHGPVAMALHGLQAAPFW
LALAGVALSYYMYMVNPALPAAIKRACMPIYTLFENKYYLDWINENIIARGARALGTGLWKGGDQAVIDGAVVNGSWKVV
GWVAGIVRWVQSGYIYHYALVMILGVFGLMTYFVWLNK
>Mature_677_residues
SQTLSASMLLAVPLAPLAGSALAGILGTAFGGNRIGRRASHTLTILGVFVAFVLSALTFKSVALDGARFNETLYTWMVVG
GLKMEVGFLVDTLTAMMMCVVTFVSLMVHIYTIGYMEEDDGYNRFFSYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVSY
LLIGFWFNKPTAIFANMKAFLVNRVGDFGFILGIGLIAAYTGTLNYGEIFARSGELGTIGFPGTDWMLITVICICLFIGA
MGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILVIGAITALFMGFLGMIQNDIKR
VVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIMGMHHNQDIRWMGAVRKYMPITWITSLLGSLAL
IGMPLFSGFYSKDSIIEAVHASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHDDHHAHDDHGHGH
GHDAKPHESPWVVTVPLVLLAIPSVVIGFLAIQPMLFGDFFKDVIFVDAAKHPAMAELSEMFHGPVAMALHGLQAAPFWL
ALAGVALSYYMYMVNPALPAAIKRACMPIYTLFENKYYLDWINENIIARGARALGTGLWKGGDQAVIDGAVVNGSWKVVG
WVAGIVRWVQSGYIYHYALVMILGVFGLMTYFVWLNK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=394, Percent_Identity=39.5939086294416, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1788614, Length=595, Percent_Identity=37.3109243697479, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1788829, Length=345, Percent_Identity=31.304347826087, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1788827, Length=411, Percent_Identity=29.4403892944039, Blast_Score=129, Evalue=9e-31,
Organism=Escherichia coli, GI1788831, Length=409, Percent_Identity=27.1393643031785, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=33.8235294117647, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI145693160, Length=338, Percent_Identity=25.1479289940828, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788613, Length=333, Percent_Identity=25.8258258258258, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74256; Mature: 74125

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQTLSASMLLAVPLAPLAGSALAGILGTAFGGNRIGRRASHTLTILGVFVAFVLSALTF
CCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KSVALDGARFNETLYTWMVVGGLKMEVGFLVDTLTAMMMCVVTFVSLMVHIYTIGYMEED
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECC
DGYNRFFSYISLFTFSMLMLVMSNNLLQLFFGWEAVGLVSYLLIGFWFNKPTAIFANMKA
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLVNRVGDFGFILGIGLIAAYTGTLNYGEIFARSGELGTIGFPGTDWMLITVICICLFIG
HHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHH
AMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALNFILV
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
IGAITALFMGFLGMIQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FLGAGSVIMGMHHNQDIRWMGAVRKYMPITWITSLLGSLALIGMPLFSGFYSKDSIIEAV
HHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
HASTLPAAGFAHFAVLAGVFVTAFYSFRMYFLVFHGKERYDQNPDAHHDDHHAHDDHGHG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCCCCCCCC
HGHDAKPHESPWVVTVPLVLLAIPSVVIGFLAIQPMLFGDFFKDVIFVDAAKHPAMAELS
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
EMFHGPVAMALHGLQAAPFWLALAGVALSYYMYMVNPALPAAIKRACMPIYTLFENKYYL
HHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEE
DWINENIIARGARALGTGLWKGGDQAVIDGAVVNGSWKVVGWVAGIVRWVQSGYIYHYAL
EECCCHHHHHCHHHHHCCCCCCCCCEEEECEEECCCCHHHHHHHHHHHHHHCCHHHHHHH
VMILGVFGLMTYFVWLNK
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]