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The map label for this gene is nuoD

Identifier: 120609953

GI number: 120609953

Start: 1389452

End: 1390705

Strand: Direct

Name: nuoD

Synonym: Aave_1266

Alternate gene names: 120609953

Gene position: 1389452-1390705 (Clockwise)

Preceding gene: 120609952

Following gene: 120609954

Centisome position: 25.96

GC content: 64.27

Gene sequence:

>1254_bases
ATGGCTGAAATCAAGAACTACTCCCTGAACTTTGGTCCGCAGCACCCGGCCGCGCACGGCGTGCTGCGCCTGGTGCTCGA
GCTCGACGGCGAAGTCGTGCAGCGCGCCGACCCCCACATCGGCCTGCTGCACCGCGCCACCGAGAAGCTGGCCGAGCACA
AGACCTTCATCCAGTCGCTGCCCTACATGGACCGGCTGGACTACGTCTCGATGATGTGCAACGAGCACGCCTACTGCCTG
GCCATCGAGAAGCTGCTGGGCATCGACGTGCCGCTGCGCGCGCAGTACATCCGCGTGATGTTCTCCGAGATCACGCGCCT
GCTGAACCACCTGATGTGGCTGGGATCGCACGGAAACGATTGCGGAAGCTCCACGATCCTGATCTACACGTTCCGCGAGC
GCGAAGACCTGTTCGACATGTACGAGGCGGTGTCGGGTGCGCGCATGCACGCGGCCTACTTCCGTCCGGGTGGCGTCTAT
CGCGACCTGCCCGACAGCATGCCGCAGTACCAGGCGAGCAAGGTGCGCAACGCCAAGGCGATCGAGGTGCTGAACCAGAA
CCGGCAGGGTTCGCTGCTGGACTTCATCGACGACTTCACGCAGCGCTTCCCCAAGTGCGTGGACGAGTACGAAACGCTGC
TGACCGACAACCGCATCTGGAAGCAGCGCACCGTGGACATCGGCATCGTGACGCCGGAGCGCGCGTTGAACCTCGGCATG
ACGGGCCCGATGCTGCGCGGCTCGGGCATCGCCTGGGACCTGCGCAAGAAGCAGCCCTACGATGCCTACGACCGCGTGGA
ATTCGACATCCCCGTGGGCAAGACGGGCGACTGCTACGACCGCTACCTCGTGCGCGTGCAGGAGATGCGCCAGTCCAACC
GCATCATCAAGCAGTGCGTGGACTGGCTCAAGGCCAACCCGGGGCCCGTCATCACCGACAACCACAAGGTGGCGCCGCCG
TCGCGCGAGTCGATGAAGTCGAACATGGAAGAGCTGATCCACCATTTCAAGCTCTTCACCGAAGGGTTCCGCGTGCCCGA
GGGCGAGGCCTATGCCGCCGTCGAGCACCCGAAGGGCGAGTTCGGCATCTACCTCGTGAGCGACGGCGCCAACAAGCCGT
ACCGGCTCAAGATCCGCGCACCGGGCTTCGCCCACCTCGCGACCCTCGACGAGATGGCGCGCGGGCACATGATCGCCGAT
GCCGTGGCCATCATTGGCACGATGGATATCGTGTTCGGAGAGATTGACCGATGA

Upstream 100 bases:

>100_bases
GGTGACGATCGAGCCGCGCGAGATCACGCCCCGCATCATCCGCGAAGAAAAGTACGGAGGCCTGCACTGAGGCGCTTCTA
GCGCATTCAGGCGATCCACG

Downstream 100 bases:

>100_bases
GTACCGAAACGAAGCAAGCCGCCGGCGCATCGCTGGTGACCGAGGCGACGCTCGCGCGCTTCGCCCGCGAGGTGGCCAAG
TACCCGCCGGAGCAGAAGCA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MAEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTFIQSLPYMDRLDYVSMMCNEHAYCL
AIEKLLGIDVPLRAQYIRVMFSEITRLLNHLMWLGSHGNDCGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVY
RDLPDSMPQYQASKVRNAKAIEVLNQNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVDIGIVTPERALNLGM
TGPMLRGSGIAWDLRKKQPYDAYDRVEFDIPVGKTGDCYDRYLVRVQEMRQSNRIIKQCVDWLKANPGPVITDNHKVAPP
SRESMKSNMEELIHHFKLFTEGFRVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGFAHLATLDEMARGHMIAD
AVAIIGTMDIVFGEIDR

Sequences:

>Translated_417_residues
MAEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTFIQSLPYMDRLDYVSMMCNEHAYCL
AIEKLLGIDVPLRAQYIRVMFSEITRLLNHLMWLGSHGNDCGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVY
RDLPDSMPQYQASKVRNAKAIEVLNQNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVDIGIVTPERALNLGM
TGPMLRGSGIAWDLRKKQPYDAYDRVEFDIPVGKTGDCYDRYLVRVQEMRQSNRIIKQCVDWLKANPGPVITDNHKVAPP
SRESMKSNMEELIHHFKLFTEGFRVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGFAHLATLDEMARGHMIAD
AVAIIGTMDIVFGEIDR
>Mature_416_residues
AEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTFIQSLPYMDRLDYVSMMCNEHAYCLA
IEKLLGIDVPLRAQYIRVMFSEITRLLNHLMWLGSHGNDCGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVYR
DLPDSMPQYQASKVRNAKAIEVLNQNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVDIGIVTPERALNLGMT
GPMLRGSGIAWDLRKKQPYDAYDRVEFDIPVGKTGDCYDRYLVRVQEMRQSNRIIKQCVDWLKANPGPVITDNHKVAPPS
RESMKSNMEELIHHFKLFTEGFRVPEGEAYAAVEHPKGEFGIYLVSDGANKPYRLKIRAPGFAHLATLDEMARGHMIADA
VAIIGTMDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=62.8019323671498, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=62.2549019607843, Blast_Score=518, Evalue=1e-147,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=37.0731707317073, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1789076, Length=420, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=27.2058823529412, Blast_Score=115, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17555284, Length=414, Percent_Identity=59.6618357487923, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17568379, Length=414, Percent_Identity=58.4541062801932, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24638644, Length=414, Percent_Identity=62.56038647343, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221459469, Length=409, Percent_Identity=57.2127139364303, Blast_Score=488, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_ACIAC (A1TLL9)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969631.1
- ProteinModelPortal:   A1TLL9
- SMR:   A1TLL9
- STRING:   A1TLL9
- GeneID:   4669207
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1266
- NMPDR:   fig|397945.5.peg.1110
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   MADVITI
- PhylomeDB:   A1TLL9
- ProtClustDB:   PRK06075
- BioCyc:   AAVE397945:AAVE_1266-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 47567; Mature: 47436

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTFIQSL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMCNEHAYCLAIEKLLGIDVPLRAQYIRVMFSEITRLLNHLMWLGSHGND
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
CGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVYRDLPDSMPQYQASKVRNAKA
CCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHH
IEVLNQNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVDIGIVTPERALNLGM
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECHHHHHCCCC
TGPMLRGSGIAWDLRKKQPYDAYDRVEFDIPVGKTGDCYDRYLVRVQEMRQSNRIIKQCV
CCCCCCCCCCEEECCCCCCCCHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLKANPGPVITDNHKVAPPSRESMKSNMEELIHHFKLFTEGFRVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
FGIYLVSDGANKPYRLKIRAPGFAHLATLDEMARGHMIADAVAIIGTMDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEIKNYSLNFGPQHPAAHGVLRLVLELDGEVVQRADPHIGLLHRATEKLAEHKTFIQSL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMCNEHAYCLAIEKLLGIDVPLRAQYIRVMFSEITRLLNHLMWLGSHGND
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
CGSSTILIYTFREREDLFDMYEAVSGARMHAAYFRPGGVYRDLPDSMPQYQASKVRNAKA
CCCCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCHHH
IEVLNQNRQGSLLDFIDDFTQRFPKCVDEYETLLTDNRIWKQRTVDIGIVTPERALNLGM
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECHHHHHCCCC
TGPMLRGSGIAWDLRKKQPYDAYDRVEFDIPVGKTGDCYDRYLVRVQEMRQSNRIIKQCV
CCCCCCCCCCEEECCCCCCCCHHHCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DWLKANPGPVITDNHKVAPPSRESMKSNMEELIHHFKLFTEGFRVPEGEAYAAVEHPKGE
HHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
FGIYLVSDGANKPYRLKIRAPGFAHLATLDEMARGHMIADAVAIIGTMDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA