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The map label for this gene is nqo2 [H]

Identifier: 120609954

GI number: 120609954

Start: 1390702

End: 1391229

Strand: Direct

Name: nqo2 [H]

Synonym: Aave_1267

Alternate gene names: 120609954

Gene position: 1390702-1391229 (Clockwise)

Preceding gene: 120609953

Following gene: 120609955

Centisome position: 25.98

GC content: 65.15

Gene sequence:

>528_bases
ATGAGTACCGAAACGAAGCAAGCCGCCGGCGCATCGCTGGTGACCGAGGCGACGCTCGCGCGCTTCGCCCGCGAGGTGGC
CAAGTACCCGCCGGAGCAGAAGCAGTCCGCCGTGATGGCCTGCCTGTCCATCGTGCAGCAGGAGCAGGGCTGGGTCAGCA
CCGAGAGCGAGGCCGTGATCGCCAGCTATCTGGGCATGCCCGAGATCGCCGTGCATGAAGTCACCACCTTCTACAACATG
TACAACCAGCAGCCGCTGGGCAAGTACAAGCTCAACGTCTGCACCAACCTGCCGTGCCAGCTGCGCGACGGCCAGAAGGC
GCTGCACCACCTCGAGAAGAAGCTCGGCATCACCATGGGCGAAACCACGCCCGACGGCCTGTTCACGCTGCAGCAGTGCG
AATGCCTGGGCGCGTGCGCCGATGCGCCCGTGATGCTGGTGAACGACCGCACGATGTGCAGCTTCATGGACAACGAGAAG
CTCGACCAGCTCGTGGACGGCCTGCGCCAGGCGGAGGGACAGGCATGA

Upstream 100 bases:

>100_bases
CCCACCTCGCGACCCTCGACGAGATGGCGCGCGGGCACATGATCGCCGATGCCGTGGCCATCATTGGCACGATGGATATC
GTGTTCGGAGAGATTGACCG

Downstream 100 bases:

>100_bases
CCACCGCAGCACAGATCCTCTCGCAGTTCCAGGCCACGGGCGTCCAGACCTGCTTCCACGACCGCCACATCGAGCCGCAG
ATCTACGCGGGCCTCGACGG

Product: NADH-quinone oxidoreductase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I chain 2; NDH-1 subunit 2 [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MSTETKQAAGASLVTEATLARFAREVAKYPPEQKQSAVMACLSIVQQEQGWVSTESEAVIASYLGMPEIAVHEVTTFYNM
YNQQPLGKYKLNVCTNLPCQLRDGQKALHHLEKKLGITMGETTPDGLFTLQQCECLGACADAPVMLVNDRTMCSFMDNEK
LDQLVDGLRQAEGQA

Sequences:

>Translated_175_residues
MSTETKQAAGASLVTEATLARFAREVAKYPPEQKQSAVMACLSIVQQEQGWVSTESEAVIASYLGMPEIAVHEVTTFYNM
YNQQPLGKYKLNVCTNLPCQLRDGQKALHHLEKKLGITMGETTPDGLFTLQQCECLGACADAPVMLVNDRTMCSFMDNEK
LDQLVDGLRQAEGQA
>Mature_174_residues
STETKQAAGASLVTEATLARFAREVAKYPPEQKQSAVMACLSIVQQEQGWVSTESEAVIASYLGMPEIAVHEVTTFYNMY
NQQPLGKYKLNVCTNLPCQLRDGQKALHHLEKKLGITMGETTPDGLFTLQQCECLGACADAPVMLVNDRTMCSFMDNEKL
DQLVDGLRQAEGQA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=158, Percent_Identity=39.873417721519, Blast_Score=135, Evalue=2e-32,
Organism=Escherichia coli, GI1788621, Length=120, Percent_Identity=38.3333333333333, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561328, Length=148, Percent_Identity=43.2432432432432, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI18859877, Length=121, Percent_Identity=41.3223140495868, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355353, Length=144, Percent_Identity=36.8055555555556, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19223; Mature: 19092

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
8.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTETKQAAGASLVTEATLARFAREVAKYPPEQKQSAVMACLSIVQQEQGWVSTESEAVI
CCCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ASYLGMPEIAVHEVTTFYNMYNQQPLGKYKLNVCTNLPCQLRDGQKALHHLEKKLGITMG
HHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
ETTPDGLFTLQQCECLGACADAPVMLVNDRTMCSFMDNEKLDQLVDGLRQAEGQA
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STETKQAAGASLVTEATLARFAREVAKYPPEQKQSAVMACLSIVQQEQGWVSTESEAVI
CCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ASYLGMPEIAVHEVTTFYNMYNQQPLGKYKLNVCTNLPCQLRDGQKALHHLEKKLGITMG
HHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
ETTPDGLFTLQQCECLGACADAPVMLVNDRTMCSFMDNEKLDQLVDGLRQAEGQA
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020134 [H]