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The map label for this gene is maeB [H]

Identifier: 120609787

GI number: 120609787

Start: 1198899

End: 1201199

Strand: Reverse

Name: maeB [H]

Synonym: Aave_1095

Alternate gene names: 120609787

Gene position: 1201199-1198899 (Counterclockwise)

Preceding gene: 120609788

Following gene: 120609786

Centisome position: 22.44

GC content: 69.49

Gene sequence:

>2301_bases
ATGACCAAGCCACTGTCCGCCGCGGAAGCGGCACTGCGCGAAGCAGCGCTCGAATACCACCGCAACCCCAGCCGCGGCAA
GATCTCCGTCACGCCGACCAAGCCCCTGTCCAACCAGCGCGACCTCTCCCTGGCCTACTCGCCCGGCGTGGCCTATCCGT
GCCTGGACATCCAGGCCGACCCGTCCCTGGCGGCCGAGTACACCTCCCGGGGCAACCTCGTGGGCGTGATCACCAACGGC
ACGGCGGTGCTGGGCCTGGGCGACATCGGCCCGCTGGCCGGCAAGCCGGTGATGGAAGGCAAGGGGTGCCTGTTCAAGAA
GTTCGCGGGTGTCGATGTGTTCGACATCGAGCTGGCCGAGCGCGACCCGGACAAGATCATCGACATCGTCGCGGCGCTGG
AGCCCACGCTGGGCGGCATCAACCTGGAAGACATCAAGGCGCCGGAGTGCTTCTACATCGAGCGCGAACTCTCCAGGCGC
ATGAACATCCCGGTGTTCCATGACGACCAGCACGGCACGGCCATCATCTCCAGCGCCGCCCTGCTCAACGGGCTGGAGCT
GGTGGGCAAGGACATCGGCGCCGTGAAGGTGGCCGTCTCCGGCGCCGGCGCCGCCGCCATCGCCTGCCTGGACGTCATGG
TCGGCCTGGGTGTCAAGCGCGAGAACATCTTCGTGTGCGACTCCAAGGGCGTGATCTACGAAGGCCGCGGCCCGCTGGAC
GAATCCAAGGCCCGCTACGCCCAGAAGACGGAGGCCCGGATCCTGGCCGACGTGGTCAACGGCGCCGACGTGTTCCTGGG
CTGCTCCACCGCCGGCACGCTCACGGCGGACATGGTCAAGACCATGGCGGACAAGCCCATCATCCTGGCGCTGGCCAACC
CGGAACCCGAGATCCGGCCCGAACTGGCCAAGGCCGTGCGCCCGGACTGCATCATCGCCACGGGCCGTTCGGACTACCCG
AACCAGGTCAACAACGTGCTGTGCTTCCCCTACATCTTCCGCGGCGCGCTCGATTGCGGCGCCACGAAGATCACGCAGGA
GATGAAGCTCGCCTGCGTGCGCGAGATCGCCGACCTCGCCAAGGCCGAGATGAGCGACGAGGTGGCCGCCGCCTACGCGG
GCCAGGACCTCTCCTTCGGCCCGGACTACCTCATCCCCACGCCGTTCGACGTGCGCCTGATCCTGCGCATCGCGCCCGCC
GTGGCGCGCGCGGCCGAGGCATCGGGCGTGGCCACCCGCCCGATCCAGGACTACGACGCCTACCGCGACAGCCTCACGCG
CTTCGTGTACCAGACCAGCATGTTCATGCGCCCGGTCTTCACCGCCGCCAAGGCCAGCCTGCAGCGCGTGGCCTATGCCG
AGGGCGAGGACGAACGCGTGCTGCGCGCCGCGCAGGTGGCCGTGGACGACGGTCTCGCCCGCCCCATCCTGATCGGCCGA
CCCGCCGTGATCGAGATGCGGATCAAGAAGGCCGGCCTGCGCATCCAGCTCGGCAAGGACGTGGAGGTCTGCGACCCCGA
GGACGATCCGCGCTTCCGCCAGTACTGGGAGGCCTACCACCGCCTGATGGGCCGCGACGGCATCACGCCCGAGGCCGCCA
AGGCCGCCGTGCGCCGCTCCAACACGCTCATCGGCGCGCTGATGGTGCGCCTGGGCGACGCGGACGCGCTGCTGTGCGGC
CTGGTCGGCCGCTTCGACCACCACCTGGAGCACGTGCGCACGGTGATCGGCCTCAAGGACGGCGCCGCGGGCCTCGCGAC
GGTGAATGCCCTCACGCTGGACCAGCACACGCTGTTCATCGCCGACACCTACATCCACGAGGATCCGAGCGCCGAGCAGC
TCGCGCACATCGCGCAGATGGCGGCCGAGGAAGTGCAGCGCTTCGGCCTGCCGCCCAAGGTCGCGTTCCTCTCGCACTCC
AACTACGGCTCGTCCACGCGCCCCTCGGCCCGCAAGATGCGCGCGGCGCGCGACCTGTTCGCGAAGGCCGCGCCGCACAT
CGAGAGCGACGGCGAACTGCACGGCGACGCGGCCCTGTCGGAGAAGATCCGCCAGAACGCGCTGGAGGACAGCACGCTCA
CCGGCTCGGCCAACGTGCTGATCTGCCCGAACCTGGACGCCGCGAACATCCTGTTCAACGTGCTCAAGACCACCGGCAGC
CACGGCACGACCATCGGCCCGATCCTGCTGGGCGCCGCCGCCTCGGCCCACGTGCTCACACCCTCGTCCACCGTGCGCCG
CGTGGTGAACATGACGGCACTGGCGGCCGCCAACGCCGTGGCCTCCAAGGCCCAGCGCTGA

Upstream 100 bases:

>100_bases
CCCCATGCACATATCGCATGGGTCCAGCACTCCCCTGGCGCGGGCCCGGCGGTTAAGCTCGATAGGCATCGCCCCTGCGC
CTTTTTTCCGGAACTCCCGT

Downstream 100 bases:

>100_bases
CGCGCCGGGCGCCATCCCTTCGGCGCGCTGCTGGTCGCGCCGGACGGCGACACCGTGCTGGCCGAGCAGGGCAACATCGA
CACGGTGAACCACGCCGAAT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 766; Mature: 765

Protein sequence:

>766_residues
MTKPLSAAEAALREAALEYHRNPSRGKISVTPTKPLSNQRDLSLAYSPGVAYPCLDIQADPSLAAEYTSRGNLVGVITNG
TAVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAERDPDKIIDIVAALEPTLGGINLEDIKAPECFYIERELSRR
MNIPVFHDDQHGTAIISSAALLNGLELVGKDIGAVKVAVSGAGAAAIACLDVMVGLGVKRENIFVCDSKGVIYEGRGPLD
ESKARYAQKTEARILADVVNGADVFLGCSTAGTLTADMVKTMADKPIILALANPEPEIRPELAKAVRPDCIIATGRSDYP
NQVNNVLCFPYIFRGALDCGATKITQEMKLACVREIADLAKAEMSDEVAAAYAGQDLSFGPDYLIPTPFDVRLILRIAPA
VARAAEASGVATRPIQDYDAYRDSLTRFVYQTSMFMRPVFTAAKASLQRVAYAEGEDERVLRAAQVAVDDGLARPILIGR
PAVIEMRIKKAGLRIQLGKDVEVCDPEDDPRFRQYWEAYHRLMGRDGITPEAAKAAVRRSNTLIGALMVRLGDADALLCG
LVGRFDHHLEHVRTVIGLKDGAAGLATVNALTLDQHTLFIADTYIHEDPSAEQLAHIAQMAAEEVQRFGLPPKVAFLSHS
NYGSSTRPSARKMRAARDLFAKAAPHIESDGELHGDAALSEKIRQNALEDSTLTGSANVLICPNLDAANILFNVLKTTGS
HGTTIGPILLGAAASAHVLTPSSTVRRVVNMTALAAANAVASKAQR

Sequences:

>Translated_766_residues
MTKPLSAAEAALREAALEYHRNPSRGKISVTPTKPLSNQRDLSLAYSPGVAYPCLDIQADPSLAAEYTSRGNLVGVITNG
TAVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAERDPDKIIDIVAALEPTLGGINLEDIKAPECFYIERELSRR
MNIPVFHDDQHGTAIISSAALLNGLELVGKDIGAVKVAVSGAGAAAIACLDVMVGLGVKRENIFVCDSKGVIYEGRGPLD
ESKARYAQKTEARILADVVNGADVFLGCSTAGTLTADMVKTMADKPIILALANPEPEIRPELAKAVRPDCIIATGRSDYP
NQVNNVLCFPYIFRGALDCGATKITQEMKLACVREIADLAKAEMSDEVAAAYAGQDLSFGPDYLIPTPFDVRLILRIAPA
VARAAEASGVATRPIQDYDAYRDSLTRFVYQTSMFMRPVFTAAKASLQRVAYAEGEDERVLRAAQVAVDDGLARPILIGR
PAVIEMRIKKAGLRIQLGKDVEVCDPEDDPRFRQYWEAYHRLMGRDGITPEAAKAAVRRSNTLIGALMVRLGDADALLCG
LVGRFDHHLEHVRTVIGLKDGAAGLATVNALTLDQHTLFIADTYIHEDPSAEQLAHIAQMAAEEVQRFGLPPKVAFLSHS
NYGSSTRPSARKMRAARDLFAKAAPHIESDGELHGDAALSEKIRQNALEDSTLTGSANVLICPNLDAANILFNVLKTTGS
HGTTIGPILLGAAASAHVLTPSSTVRRVVNMTALAAANAVASKAQR
>Mature_765_residues
TKPLSAAEAALREAALEYHRNPSRGKISVTPTKPLSNQRDLSLAYSPGVAYPCLDIQADPSLAAEYTSRGNLVGVITNGT
AVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAERDPDKIIDIVAALEPTLGGINLEDIKAPECFYIERELSRRM
NIPVFHDDQHGTAIISSAALLNGLELVGKDIGAVKVAVSGAGAAAIACLDVMVGLGVKRENIFVCDSKGVIYEGRGPLDE
SKARYAQKTEARILADVVNGADVFLGCSTAGTLTADMVKTMADKPIILALANPEPEIRPELAKAVRPDCIIATGRSDYPN
QVNNVLCFPYIFRGALDCGATKITQEMKLACVREIADLAKAEMSDEVAAAYAGQDLSFGPDYLIPTPFDVRLILRIAPAV
ARAAEASGVATRPIQDYDAYRDSLTRFVYQTSMFMRPVFTAAKASLQRVAYAEGEDERVLRAAQVAVDDGLARPILIGRP
AVIEMRIKKAGLRIQLGKDVEVCDPEDDPRFRQYWEAYHRLMGRDGITPEAAKAAVRRSNTLIGALMVRLGDADALLCGL
VGRFDHHLEHVRTVIGLKDGAAGLATVNALTLDQHTLFIADTYIHEDPSAEQLAHIAQMAAEEVQRFGLPPKVAFLSHSN
YGSSTRPSARKMRAARDLFAKAAPHIESDGELHGDAALSEKIRQNALEDSTLTGSANVLICPNLDAANILFNVLKTTGSH
GTTIGPILLGAAASAHVLTPSSTVRRVVNMTALAAANAVASKAQR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=342, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI62420882, Length=345, Percent_Identity=27.2463768115942, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI62420880, Length=345, Percent_Identity=27.2463768115942, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI239049447, Length=345, Percent_Identity=27.2463768115942, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI4505145, Length=354, Percent_Identity=26.8361581920904, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1788806, Length=750, Percent_Identity=62.1333333333333, Blast_Score=964, Evalue=0.0,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=31.4285714285714, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788635, Length=354, Percent_Identity=27.683615819209, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI87081919, Length=292, Percent_Identity=25, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322823, Length=249, Percent_Identity=31.7269076305221, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356279, Length=506, Percent_Identity=27.6679841897233, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281362672, Length=476, Percent_Identity=27.9411764705882, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI281362674, Length=476, Percent_Identity=27.9411764705882, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646386, Length=402, Percent_Identity=29.3532338308458, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646388, Length=402, Percent_Identity=29.3532338308458, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81903; Mature: 81772

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPLSAAEAALREAALEYHRNPSRGKISVTPTKPLSNQRDLSLAYSPGVAYPCLDIQAD
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCEEECCCC
PSLAAEYTSRGNLVGVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAE
CCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECC
RDPDKIIDIVAALEPTLGGINLEDIKAPECFYIERELSRRMNIPVFHDDQHGTAIISSAA
CCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHHCCCCEEECCCCCHHHHHHHH
LLNGLELVGKDIGAVKVAVSGAGAAAIACLDVMVGLGVKRENIFVCDSKGVIYEGRGPLD
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCC
ESKARYAQKTEARILADVVNGADVFLGCSTAGTLTADMVKTMADKPIILALANPEPEIRP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCH
ELAKAVRPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITQEMKLACVREIADLA
HHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KAEMSDEVAAAYAGQDLSFGPDYLIPTPFDVRLILRIAPAVARAAEASGVATRPIQDYDA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
YRDSLTRFVYQTSMFMRPVFTAAKASLQRVAYAEGEDERVLRAAQVAVDDGLARPILIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECC
PAVIEMRIKKAGLRIQLGKDVEVCDPEDDPRFRQYWEAYHRLMGRDGITPEAAKAAVRRS
CCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NTLIGALMVRLGDADALLCGLVGRFDHHLEHVRTVIGLKDGAAGLATVNALTLDQHTLFI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEE
ADTYIHEDPSAEQLAHIAQMAAEEVQRFGLPPKVAFLSHSNYGSSTRPSARKMRAARDLF
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
AKAAPHIESDGELHGDAALSEKIRQNALEDSTLTGSANVLICPNLDAANILFNVLKTTGS
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCC
HGTTIGPILLGAAASAHVLTPSSTVRRVVNMTALAAANAVASKAQR
CCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKPLSAAEAALREAALEYHRNPSRGKISVTPTKPLSNQRDLSLAYSPGVAYPCLDIQAD
CCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCCCEEECCCC
PSLAAEYTSRGNLVGVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAE
CCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECC
RDPDKIIDIVAALEPTLGGINLEDIKAPECFYIERELSRRMNIPVFHDDQHGTAIISSAA
CCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEHHHHHHCCCCEEECCCCCHHHHHHHH
LLNGLELVGKDIGAVKVAVSGAGAAAIACLDVMVGLGVKRENIFVCDSKGVIYEGRGPLD
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCC
ESKARYAQKTEARILADVVNGADVFLGCSTAGTLTADMVKTMADKPIILALANPEPEIRP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCH
ELAKAVRPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITQEMKLACVREIADLA
HHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
KAEMSDEVAAAYAGQDLSFGPDYLIPTPFDVRLILRIAPAVARAAEASGVATRPIQDYDA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
YRDSLTRFVYQTSMFMRPVFTAAKASLQRVAYAEGEDERVLRAAQVAVDDGLARPILIGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEECC
PAVIEMRIKKAGLRIQLGKDVEVCDPEDDPRFRQYWEAYHRLMGRDGITPEAAKAAVRRS
CCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NTLIGALMVRLGDADALLCGLVGRFDHHLEHVRTVIGLKDGAAGLATVNALTLDQHTLFI
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEE
ADTYIHEDPSAEQLAHIAQMAAEEVQRFGLPPKVAFLSHSNYGSSTRPSARKMRAARDLF
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
AKAAPHIESDGELHGDAALSEKIRQNALEDSTLTGSANVLICPNLDAANILFNVLKTTGS
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCC
HGTTIGPILLGAAASAHVLTPSSTVRRVVNMTALAAANAVASKAQR
CCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]