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The map label for this gene is hisA

Identifier: 120609727

GI number: 120609727

Start: 1132300

End: 1133046

Strand: Direct

Name: hisA

Synonym: Aave_1034

Alternate gene names: 120609727

Gene position: 1132300-1133046 (Clockwise)

Preceding gene: 120609726

Following gene: 120609737

Centisome position: 21.15

GC content: 67.87

Gene sequence:

>747_bases
ATGCTGCTCATCCCCGCCATCGACCTCAAGGACGGACACTGCGTGCGCCTCAAGCAAGGTGACATGGATCAATCGACCAC
CTTCGGCGAAGACCCGGCAGCCATGGCGCGCAAGTGGGTGGATGCCGGCGCCCGCCGCCTGCACCTCGTGGACCTGAACG
GCGCCTTCGCCGGCGCGCCCAAGAACCACGCCGCGATCAAGGCCATCCTCAAGGAGGTGGGCGACGACCTGCCCGTGCAG
CTGGGCGGCGGCATCCGCGACCTGGACACGATCGAGAAATACATCGACGGCGGCCTGCGCTACGTGATCATCGGCACCGC
GGCCGTCAAGAACCCCGGATTCCTGAAGGATGCCTGCAGCGCCTTCGGCGGCCACATCATCGTGGGCCTGGACGCCAAGG
ACGGCAAGGTCGCCACCGACGGCTGGAGCAAGCTGACCGGCCACGAGGTGGTCGACCTCGCGAAGAGGTTCGAGGACTGG
GGCGTCGAATCCATCGTCTATACCGACATCGGCCGCGACGGCATGCTCTCGGGCATCAACATCGAGGCCACGGTGAAGCT
GGCGCAGGCCCTCACCATCCCCGTGATCGCCTCCGGCGGCCTGGCGGGCATGGCCGACATCGAGCAGCTCTGCGCGGTGG
AGAGCGAAGGCGTGGAAGGCGTCATCTGCGGCCGTGCGATCTATTCCGGCGACCTCGACTTCGCCGCGGCGCAGGCGCGC
GCGGACGAGCTGAACGGCGCGGCCTGA

Upstream 100 bases:

>100_bases
GGAATCCCTGAGCAATCTCCCTCGCTTCCTATCCTCTTTCTTCCACCCGGCCGGCACTGGCACGCCCTGCCACGGCATTT
CCCCACCTCGTCATTCCATC

Downstream 100 bases:

>100_bases
CCCTCCTGCGCCGCAGGTGCGCCGGCCGCTTCAGCAGGCCGGCGGCGGGCGCCCCTGGTTCATGGCCGCCACGGTCTGCA
GCAGGGCCGTCCAGTACGAG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLLIPAIDLKDGHCVRLKQGDMDQSTTFGEDPAAMARKWVDAGARRLHLVDLNGAFAGAPKNHAAIKAILKEVGDDLPVQ
LGGGIRDLDTIEKYIDGGLRYVIIGTAAVKNPGFLKDACSAFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKRFEDW
GVESIVYTDIGRDGMLSGINIEATVKLAQALTIPVIASGGLAGMADIEQLCAVESEGVEGVICGRAIYSGDLDFAAAQAR
ADELNGAA

Sequences:

>Translated_248_residues
MLLIPAIDLKDGHCVRLKQGDMDQSTTFGEDPAAMARKWVDAGARRLHLVDLNGAFAGAPKNHAAIKAILKEVGDDLPVQ
LGGGIRDLDTIEKYIDGGLRYVIIGTAAVKNPGFLKDACSAFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKRFEDW
GVESIVYTDIGRDGMLSGINIEATVKLAQALTIPVIASGGLAGMADIEQLCAVESEGVEGVICGRAIYSGDLDFAAAQAR
ADELNGAA
>Mature_248_residues
MLLIPAIDLKDGHCVRLKQGDMDQSTTFGEDPAAMARKWVDAGARRLHLVDLNGAFAGAPKNHAAIKAILKEVGDDLPVQ
LGGGIRDLDTIEKYIDGGLRYVIIGTAAVKNPGFLKDACSAFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKRFEDW
GVESIVYTDIGRDGMLSGINIEATVKLAQALTIPVIASGGLAGMADIEQLCAVESEGVEGVICGRAIYSGDLDFAAAQAR
ADELNGAA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=33.1967213114754, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788336, Length=213, Percent_Identity=24.4131455399061, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_ACIAC (A1TKZ3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969405.1
- ProteinModelPortal:   A1TKZ3
- STRING:   A1TKZ3
- GeneID:   4668936
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1034
- NMPDR:   fig|397945.5.peg.899
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   A1TKZ3
- ProtClustDB:   PRK00748
- BioCyc:   AAVE397945:AAVE_1034-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25956; Mature: 25956

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIPAIDLKDGHCVRLKQGDMDQSTTFGEDPAAMARKWVDAGARRLHLVDLNGAFAGAP
CEEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNHAAIKAILKEVGDDLPVQLGGGIRDLDTIEKYIDGGLRYVIIGTAAVKNPGFLKDACS
CCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKRFEDWGVESIVYTDIGRDGMLSGIN
HCCCEEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
IEATVKLAQALTIPVIASGGLAGMADIEQLCAVESEGVEGVICGRAIYSGDLDFAAAQAR
HHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCEEECCCCCHHHHHHH
ADELNGAA
HHHCCCCC
>Mature Secondary Structure
MLLIPAIDLKDGHCVRLKQGDMDQSTTFGEDPAAMARKWVDAGARRLHLVDLNGAFAGAP
CEEEEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCC
KNHAAIKAILKEVGDDLPVQLGGGIRDLDTIEKYIDGGLRYVIIGTAAVKNPGFLKDACS
CCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHH
AFGGHIIVGLDAKDGKVATDGWSKLTGHEVVDLAKRFEDWGVESIVYTDIGRDGMLSGIN
HCCCEEEEEEECCCCEEECCCCHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
IEATVKLAQALTIPVIASGGLAGMADIEQLCAVESEGVEGVICGRAIYSGDLDFAAAQAR
HHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCEEECCCCCHHHHHHH
ADELNGAA
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA