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The map label for this gene is hisB

Identifier: 120609725

GI number: 120609725

Start: 1130903

End: 1131532

Strand: Direct

Name: hisB

Synonym: Aave_1032

Alternate gene names: 120609725

Gene position: 1130903-1131532 (Clockwise)

Preceding gene: 120609724

Following gene: 120609726

Centisome position: 21.13

GC content: 67.62

Gene sequence:

>630_bases
ATGACTTCCTCCGCACTCGTTCCCTCCACCGCCTCCGAGGGCGACCGCATCGCCGAGGTCGCCCGCAACACCGCCGAGAC
CCGCATCCGCGTGCGCGTGAACCTCGACGGCACGGGCAATGCCCGCCTGTCCTCGGGCATCGGCTTCTTCGACCACATGC
TCGACCAGATCGCGCGGCACGGCCTGATCGACCTGGACATCGAGTGCGAGGGCGACCTGCACATCGACGGACACCACACG
GTGGAAGACGTGGGCATCACGCTGGGCCAGGCGTTCGCGCGGGCCGTGGGCGACAAGAAGGGCATCCGCCGCTACGGCCA
TGCCTATGTGCCGCTCGACGAGGCGCTCTCGCGCGTGGTGGTCGATTTCTCGGGCCGGCCGGGCCTGCACATGGACGTGA
AGTTCACGGCCGGCAGCATCGGCCAGCTCGATACCCAGCTGGTGTACGAGTTCTTCCAGGGCTTCGTGAACCATGCGGGC
GTGACGCTGCACATCGACAACCTGAAGGGCTTCAATGCCCACCACCAGTGCGAAACCATCTTCAAGGCCTTCGCGCGAGC
GCTGCGCGCAGCGCTCGCGCGCGACCCGCGCTCGGCCGGCGTCATTCCCTCCACCAAGGGCTCGCTCTAG

Upstream 100 bases:

>100_bases
ACGTTTCTACAATGCATCCCTTGCTGGCCCGCTGCCTGCGCCTCACGGTGGGCAGCGAGGCCGACAACGCCCAGATGCTC
GACGCGCTCCAGGCTTCCCT

Downstream 100 bases:

>100_bases
GCTGCCACCATGAATGTTGAAGCAAAGACTGTCGCCGTCGTGGACTACGGCATGGGGAACCTGCGCTCGGTGTCCCAGGC
CGTGCAGGCCGCCGCCGAGG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTSSALVPSTASEGDRIAEVARNTAETRIRVRVNLDGTGNARLSSGIGFFDHMLDQIARHGLIDLDIECEGDLHIDGHHT
VEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVVVDFSGRPGLHMDVKFTAGSIGQLDTQLVYEFFQGFVNHAG
VTLHIDNLKGFNAHHQCETIFKAFARALRAALARDPRSAGVIPSTKGSL

Sequences:

>Translated_209_residues
MTSSALVPSTASEGDRIAEVARNTAETRIRVRVNLDGTGNARLSSGIGFFDHMLDQIARHGLIDLDIECEGDLHIDGHHT
VEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVVVDFSGRPGLHMDVKFTAGSIGQLDTQLVYEFFQGFVNHAG
VTLHIDNLKGFNAHHQCETIFKAFARALRAALARDPRSAGVIPSTKGSL
>Mature_208_residues
TSSALVPSTASEGDRIAEVARNTAETRIRVRVNLDGTGNARLSSGIGFFDHMLDQIARHGLIDLDIECEGDLHIDGHHTV
EDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVVVDFSGRPGLHMDVKFTAGSIGQLDTQLVYEFFQGFVNHAGV
TLHIDNLKGFNAHHQCETIFKAFARALRAALARDPRSAGVIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=196, Percent_Identity=49.4897959183673, Blast_Score=186, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=219, Percent_Identity=39.7260273972603, Blast_Score=162, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_ACIAC (A1TKZ1)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969403.1
- ProteinModelPortal:   A1TKZ1
- SMR:   A1TKZ1
- STRING:   A1TKZ1
- GeneID:   4669510
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1032
- NMPDR:   fig|397945.5.peg.897
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   A1TKZ1
- ProtClustDB:   PRK00951
- BioCyc:   AAVE397945:AAVE_1032-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22617; Mature: 22486

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSALVPSTASEGDRIAEVARNTAETRIRVRVNLDGTGNARLSSGIGFFDHMLDQIARH
CCCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEEECCCCCCHHHCCCCHHHHHHHHHHHC
GLIDLDIECEGDLHIDGHHTVEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVV
CCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHH
VDFSGRPGLHMDVKFTAGSIGQLDTQLVYEFFQGFVNHAGVTLHIDNLKGFNAHHQCETI
HCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
FKAFARALRAALARDPRSAGVIPSTKGSL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSSALVPSTASEGDRIAEVARNTAETRIRVRVNLDGTGNARLSSGIGFFDHMLDQIARH
CCCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEEECCCCCCHHHCCCCHHHHHHHHHHHC
GLIDLDIECEGDLHIDGHHTVEDVGITLGQAFARAVGDKKGIRRYGHAYVPLDEALSRVV
CCEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHH
VDFSGRPGLHMDVKFTAGSIGQLDTQLVYEFFQGFVNHAGVTLHIDNLKGFNAHHQCETI
HCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
FKAFARALRAALARDPRSAGVIPSTKGSL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA