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The map label for this gene is hisC

Identifier: 120609724

GI number: 120609724

Start: 1129794

End: 1130906

Strand: Direct

Name: hisC

Synonym: Aave_1031

Alternate gene names: 120609724

Gene position: 1129794-1130906 (Clockwise)

Preceding gene: 120609723

Following gene: 120609725

Centisome position: 21.11

GC content: 70.98

Gene sequence:

>1113_bases
ATGACCGACACCCTTGCCGCCGCGCTCGGCCGCATCCGCCCCGACGTCCGTGCCATGCATGCCTACGCGGTACAGCCCGC
CACCGGCGTGCTCAAGATGGACGCGATGGAAAACCCCTTTCCCCTGCCGCCGGAACTCCAGGAGGCCCTCGGCCGGCGCC
TGGGCGCCCTGGCGCTGAACCGCTACCCCGGCGCGCGGCTGACGGACCTGAAAAGTGCCCTCGCCGCGCACATCGGCATG
CCCGAAGGCTTCTCGATGGTGCTGGGCAACGGCTCGGACGAGATCATCACGCTGCTGGCTCTGGCCTGCGCACGGCCGGG
CACGGGCGAGCGCGCGGCCATGCTCGCGCCCATGCCCGGCTTCGTGATGTACCCGATGAGCGCGCAACTGCAGGGCCTGG
ACTTCGTGGCCGTGCCGCTCACGGCCGATTTCGAGCTCGACGAGCCCGCCATGCTGGCCGCCATCGCGCAGCACCGCCCG
GCGATCACCTACCTGGCCTACCCCAACAACCCCACGGCCACGCTGTGGGACGAGGGGGCGGTGCAGCGCGTCATCGACGC
GGCGGGCGCGCAGGGCGGCATCGTGGTGATGGACGAGGCCTACCAGCCCTTCGCGAGCCGCACCTGGCTGGACCGCATGC
GCGCCGAGCCCGTCCGCAACGCCCATGTGCTGCTCATGCGCACCCTCAGCAAGTTCGGCCTGGCGGGCGTGCGCCTGGGC
TACCTCGCGGGCCCTGCGGCGCTCGTGGACGAGATCGAAAAGGTGCGCCCTCCCTACAACGTGAGCGTGCTCAACTGCGA
GGCGGCGTTGTTCGCGCTGGAGCATGCCCGGGTGTTCGCCGCGCAGGCGGCCGAGCTGCGCGCCGTGCGCACCCGGCTGG
TCGCGGCACTGCGCGCCATGCCGGGCATCGAGCGCGTGTGGGACAGCGAGGCCAACATGGTGCTCGTGCGCGTGCCCGAC
GCCGCGCGGGCCTTCGAGGGCATGAAGGCCCGCAAGGTTCTCGTCAAGAACGTTTCTACAATGCATCCCTTGCTGGCCCG
CTGCCTGCGCCTCACGGTGGGCAGCGAGGCCGACAACGCCCAGATGCTCGACGCGCTCCAGGCTTCCCTATGA

Upstream 100 bases:

>100_bases
GCCACGTGCTGGGCGACGTGCTGCCGCACGGGCAGCGGTACGACGCGGTGCGCGCCGTGAATCCCTTTCTACTGGCTCCC
GACGAACTGGAATCGCTCGA

Downstream 100 bases:

>100_bases
CTTCCTCCGCACTCGTTCCCTCCACCGCCTCCGAGGGCGACCGCATCGCCGAGGTCGCCCGCAACACCGCCGAGACCCGC
ATCCGCGTGCGCGTGAACCT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTDTLAAALGRIRPDVRAMHAYAVQPATGVLKMDAMENPFPLPPELQEALGRRLGALALNRYPGARLTDLKSALAAHIGM
PEGFSMVLGNGSDEIITLLALACARPGTGERAAMLAPMPGFVMYPMSAQLQGLDFVAVPLTADFELDEPAMLAAIAQHRP
AITYLAYPNNPTATLWDEGAVQRVIDAAGAQGGIVVMDEAYQPFASRTWLDRMRAEPVRNAHVLLMRTLSKFGLAGVRLG
YLAGPAALVDEIEKVRPPYNVSVLNCEAALFALEHARVFAAQAAELRAVRTRLVAALRAMPGIERVWDSEANMVLVRVPD
AARAFEGMKARKVLVKNVSTMHPLLARCLRLTVGSEADNAQMLDALQASL

Sequences:

>Translated_370_residues
MTDTLAAALGRIRPDVRAMHAYAVQPATGVLKMDAMENPFPLPPELQEALGRRLGALALNRYPGARLTDLKSALAAHIGM
PEGFSMVLGNGSDEIITLLALACARPGTGERAAMLAPMPGFVMYPMSAQLQGLDFVAVPLTADFELDEPAMLAAIAQHRP
AITYLAYPNNPTATLWDEGAVQRVIDAAGAQGGIVVMDEAYQPFASRTWLDRMRAEPVRNAHVLLMRTLSKFGLAGVRLG
YLAGPAALVDEIEKVRPPYNVSVLNCEAALFALEHARVFAAQAAELRAVRTRLVAALRAMPGIERVWDSEANMVLVRVPD
AARAFEGMKARKVLVKNVSTMHPLLARCLRLTVGSEADNAQMLDALQASL
>Mature_369_residues
TDTLAAALGRIRPDVRAMHAYAVQPATGVLKMDAMENPFPLPPELQEALGRRLGALALNRYPGARLTDLKSALAAHIGMP
EGFSMVLGNGSDEIITLLALACARPGTGERAAMLAPMPGFVMYPMSAQLQGLDFVAVPLTADFELDEPAMLAAIAQHRPA
ITYLAYPNNPTATLWDEGAVQRVIDAAGAQGGIVVMDEAYQPFASRTWLDRMRAEPVRNAHVLLMRTLSKFGLAGVRLGY
LAGPAALVDEIEKVRPPYNVSVLNCEAALFALEHARVFAAQAAELRAVRTRLVAALRAMPGIERVWDSEANMVLVRVPDA
ARAFEGMKARKVLVKNVSTMHPLLARCLRLTVGSEADNAQMLDALQASL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=337, Percent_Identity=31.1572700296736, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322075, Length=393, Percent_Identity=26.2086513994911, Blast_Score=116, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_ACIAC (A1TKZ0)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969402.1
- ProteinModelPortal:   A1TKZ0
- SMR:   A1TKZ0
- STRING:   A1TKZ0
- GeneID:   4669638
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1031
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   MDEAYQP
- PhylomeDB:   A1TKZ0
- ProtClustDB:   PRK04870
- BioCyc:   AAVE397945:AAVE_1031-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39826; Mature: 39695

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTLAAALGRIRPDVRAMHAYAVQPATGVLKMDAMENPFPLPPELQEALGRRLGALALN
CCHHHHHHHHHCCCHHHHHHHHEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHC
RYPGARLTDLKSALAAHIGMPEGFSMVLGNGSDEIITLLALACARPGTGERAAMLAPMPG
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCC
FVMYPMSAQLQGLDFVAVPLTADFELDEPAMLAAIAQHRPAITYLAYPNNPTATLWDEGA
EEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEECCCHH
VQRVIDAAGAQGGIVVMDEAYQPFASRTWLDRMRAEPVRNAHVLLMRTLSKFGLAGVRLG
HHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHH
YLAGPAALVDEIEKVRPPYNVSVLNCEAALFALEHARVFAAQAAELRAVRTRLVAALRAM
HHCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGIERVWDSEANMVLVRVPDAARAFEGMKARKVLVKNVSTMHPLLARCLRLTVGSEADNA
CCHHHHHCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QMLDALQASL
HHHHHHHHCC
>Mature Secondary Structure 
TDTLAAALGRIRPDVRAMHAYAVQPATGVLKMDAMENPFPLPPELQEALGRRLGALALN
CHHHHHHHHHCCCHHHHHHHHEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHC
RYPGARLTDLKSALAAHIGMPEGFSMVLGNGSDEIITLLALACARPGTGERAAMLAPMPG
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCC
FVMYPMSAQLQGLDFVAVPLTADFELDEPAMLAAIAQHRPAITYLAYPNNPTATLWDEGA
EEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCEEECCCHH
VQRVIDAAGAQGGIVVMDEAYQPFASRTWLDRMRAEPVRNAHVLLMRTLSKFGLAGVRLG
HHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHH
YLAGPAALVDEIEKVRPPYNVSVLNCEAALFALEHARVFAAQAAELRAVRTRLVAALRAM
HHCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PGIERVWDSEANMVLVRVPDAARAFEGMKARKVLVKNVSTMHPLLARCLRLTVGSEADNA
CCHHHHHCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QMLDALQASL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA