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The map label for this gene is murA

Identifier: 120609716

GI number: 120609716

Start: 1121507

End: 1122811

Strand: Direct

Name: murA

Synonym: Aave_1022

Alternate gene names: 120609716

Gene position: 1121507-1122811 (Clockwise)

Preceding gene: 120609715

Following gene: 120609717

Centisome position: 20.95

GC content: 71.19

Gene sequence:

>1305_bases
ATGGACCAACTCCAGATTCGCGGCGGCCGTGCCCTGAGCGGCGACGTGCCGATCTCCGGCGCAAAGAACGCCGCATTGCC
CGAGCTGTGCGCCGCGCTGCTCACGGCCGAACCCGTCACCCTCCTGAACGTGCCGCGGCTGCAGGACGTGGCGACCATGC
TGCAGCTCATCCGCAACATGGGCGTGGCGGCCGAGCATTCCCAGGGCGACGACCGCGCCAGCAGCGGCACGGTGCGCATC
GATGCCGGCGCGCTGTCCACGCCCGAGGCGCCCTACGAGCTGGTCAAGACCATGCGCGCGTCGGTGCTGGCGCTGGGCCC
GCTGCTGGCGCGTTTCGGCGAGGCCACGGTGTCGCTGCCCGGTGGCTGCGCCATCGGCTCGCGCCCCGTGGACCAGCACA
TCAAGGGCCTGTCGGCCATGGGCGCGGAGATCGTGGTGGAGCACGGCTACATGATCGCGCGTCTGCCCGAGGGCCGTTCG
CGCCTGCAGGGCGCCCGCATCACCACCGACATGGTCACGGTGACCGGCACCGAGAACCTGCTCATGGCGGCCACGCTGGC
GGATGGCGAGACCGTGCTGGAGAATGCGGCCCAGGAACCCGAGGTGGTGGACCTGGCCGAGATGCTCATCGCCATGGGCG
CGCAGATCGAGGGCCACGGCACGAGCCGCATCCGGGTGCAGGGCGTGGAGCGCCTGCACGGCTGCACGCACCGCGTGGTG
GCCGACCGCATCGAGGCCGGCACCTTCCTGTGCGCGGTGGCCGCGACGGGCGGCGAGGCGCTGCTGCGCCATGGCCGCGC
CGACCACCTGGACGCCGTCATCGACAAGCTGCGCGACGCGGGCGTCACCGTGGAGGCCGTCGATGGCGGCATCCGCGTGC
GCAGCCCGGGCGCGGGCCAGTTGCAGGCGCAGAGCTTCCGCACCACCGAGTACCCGGGGTTTCCCACGGACATGCAGGCG
CAGTTCATGGCGCTCAACGTGGTGGCGCAGGGTACTTCGCGCGTGACCGAGACCATTTTCGAGAACCGCTTCATGCACGT
GGACGAATTGCTGCGCCTGGGCGCGCGCATCCAGGCCGACGGCAAGGTGGCGGTGATCGAGGGGCTCGGCGACACGGGCG
CGCTGCTGTCGGGCGCCACCGTGATGGCCACCGACCTGCGCGCTTCCGCGAGCCTGGTGATCGCCGGCCTCGTGGCCACG
GGCCAGACCACGGTGGACCGCATCTACCACCTCGACCGCGGCTACGACTGCATGGAAGGCAAGCTGCGCGCCCTGGGCGC
CGATATCGAAAGGGTGAAGGCATGA

Upstream 100 bases:

>100_bases
TGGGCCGCGCAGCCGCGTGGCGAATGAACGCAGGGCCCCGTCCGCTGCACCATCCGCGCAACGGCCCCTTCCCGTCCTCC
AGACCCCAGAACAACAAGCC

Downstream 100 bases:

>100_bases
CGACCCCGGGCGACGTGATCACCCTGGCCCTGTCCAAGGGCCGCATCTTCGACGAAACCCTCCCGCTGCTGGCAGCCGCC
GGCATCGAGGTGCTGGAAGA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDQLQIRGGRALSGDVPISGAKNAALPELCAALLTAEPVTLLNVPRLQDVATMLQLIRNMGVAAEHSQGDDRASSGTVRI
DAGALSTPEAPYELVKTMRASVLALGPLLARFGEATVSLPGGCAIGSRPVDQHIKGLSAMGAEIVVEHGYMIARLPEGRS
RLQGARITTDMVTVTGTENLLMAATLADGETVLENAAQEPEVVDLAEMLIAMGAQIEGHGTSRIRVQGVERLHGCTHRVV
ADRIEAGTFLCAVAATGGEALLRHGRADHLDAVIDKLRDAGVTVEAVDGGIRVRSPGAGQLQAQSFRTTEYPGFPTDMQA
QFMALNVVAQGTSRVTETIFENRFMHVDELLRLGARIQADGKVAVIEGLGDTGALLSGATVMATDLRASASLVIAGLVAT
GQTTVDRIYHLDRGYDCMEGKLRALGADIERVKA

Sequences:

>Translated_434_residues
MDQLQIRGGRALSGDVPISGAKNAALPELCAALLTAEPVTLLNVPRLQDVATMLQLIRNMGVAAEHSQGDDRASSGTVRI
DAGALSTPEAPYELVKTMRASVLALGPLLARFGEATVSLPGGCAIGSRPVDQHIKGLSAMGAEIVVEHGYMIARLPEGRS
RLQGARITTDMVTVTGTENLLMAATLADGETVLENAAQEPEVVDLAEMLIAMGAQIEGHGTSRIRVQGVERLHGCTHRVV
ADRIEAGTFLCAVAATGGEALLRHGRADHLDAVIDKLRDAGVTVEAVDGGIRVRSPGAGQLQAQSFRTTEYPGFPTDMQA
QFMALNVVAQGTSRVTETIFENRFMHVDELLRLGARIQADGKVAVIEGLGDTGALLSGATVMATDLRASASLVIAGLVAT
GQTTVDRIYHLDRGYDCMEGKLRALGADIERVKA
>Mature_434_residues
MDQLQIRGGRALSGDVPISGAKNAALPELCAALLTAEPVTLLNVPRLQDVATMLQLIRNMGVAAEHSQGDDRASSGTVRI
DAGALSTPEAPYELVKTMRASVLALGPLLARFGEATVSLPGGCAIGSRPVDQHIKGLSAMGAEIVVEHGYMIARLPEGRS
RLQGARITTDMVTVTGTENLLMAATLADGETVLENAAQEPEVVDLAEMLIAMGAQIEGHGTSRIRVQGVERLHGCTHRVV
ADRIEAGTFLCAVAATGGEALLRHGRADHLDAVIDKLRDAGVTVEAVDGGIRVRSPGAGQLQAQSFRTTEYPGFPTDMQA
QFMALNVVAQGTSRVTETIFENRFMHVDELLRLGARIQADGKVAVIEGLGDTGALLSGATVMATDLRASASLVIAGLVAT
GQTTVDRIYHLDRGYDCMEGKLRALGADIERVKA

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=433, Percent_Identity=54.0415704387991, Blast_Score=438, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_ACIAC (A1TKY2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969394.1
- ProteinModelPortal:   A1TKY2
- SMR:   A1TKY2
- STRING:   A1TKY2
- GeneID:   4669747
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1022
- NMPDR:   fig|397945.5.peg.890
- eggNOG:   COG0766
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- PhylomeDB:   A1TKY2
- ProtClustDB:   PRK09369
- BioCyc:   AAVE397945:AAVE_1022-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45638; Mature: 45638

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQLQIRGGRALSGDVPISGAKNAALPELCAALLTAEPVTLLNVPRLQDVATMLQLIRNM
CCCEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHC
GVAAEHSQGDDRASSGTVRIDAGALSTPEAPYELVKTMRASVLALGPLLARFGEATVSLP
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
GGCAIGSRPVDQHIKGLSAMGAEIVVEHGYMIARLPEGRSRLQGARITTDMVTVTGTENL
CCCCCCCCCHHHHHHHHHHCCHHEEEECCEEEEECCCCHHHHCCCEEEEEEEEEECCCCE
LMAATLADGETVLENAAQEPEVVDLAEMLIAMGAQIEGHGTSRIRVQGVERLHGCTHRVV
EEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCEEEEECHHHHHHHHHHHH
ADRIEAGTFLCAVAATGGEALLRHGRADHLDAVIDKLRDAGVTVEAVDGGIRVRSPGAGQ
HHHHCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCC
LQAQSFRTTEYPGFPTDMQAQFMALNVVAQGTSRVTETIFENRFMHVDELLRLGARIQAD
EECCCCCCCCCCCCCCCHHHHHHEEHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCEEECC
GKVAVIEGLGDTGALLSGATVMATDLRASASLVIAGLVATGQTTVDRIYHLDRGYDCMEG
CCEEEEECCCCCCHHHCCCEEEEEHHHCCHHEEEEEHHHCCCHHHHHHHHHCCCCCHHHH
KLRALGADIERVKA
HHHHHCCCHHHHCC
>Mature Secondary Structure
MDQLQIRGGRALSGDVPISGAKNAALPELCAALLTAEPVTLLNVPRLQDVATMLQLIRNM
CCCEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHC
GVAAEHSQGDDRASSGTVRIDAGALSTPEAPYELVKTMRASVLALGPLLARFGEATVSLP
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
GGCAIGSRPVDQHIKGLSAMGAEIVVEHGYMIARLPEGRSRLQGARITTDMVTVTGTENL
CCCCCCCCCHHHHHHHHHHCCHHEEEECCEEEEECCCCHHHHCCCEEEEEEEEEECCCCE
LMAATLADGETVLENAAQEPEVVDLAEMLIAMGAQIEGHGTSRIRVQGVERLHGCTHRVV
EEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCEEEEECHHHHHHHHHHHH
ADRIEAGTFLCAVAATGGEALLRHGRADHLDAVIDKLRDAGVTVEAVDGGIRVRSPGAGQ
HHHHCCCEEEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCC
LQAQSFRTTEYPGFPTDMQAQFMALNVVAQGTSRVTETIFENRFMHVDELLRLGARIQAD
EECCCCCCCCCCCCCCCHHHHHHEEHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCEEECC
GKVAVIEGLGDTGALLSGATVMATDLRASASLVIAGLVATGQTTVDRIYHLDRGYDCMEG
CCEEEEECCCCCCHHHCCCEEEEEHHHCCHHEEEEEHHHCCCHHHHHHHHHCCCCCHHHH
KLRALGADIERVKA
HHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA