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The map label for this gene is hisG

Identifier: 120609717

GI number: 120609717

Start: 1122808

End: 1123476

Strand: Direct

Name: hisG

Synonym: Aave_1023

Alternate gene names: 120609717

Gene position: 1122808-1123476 (Clockwise)

Preceding gene: 120609716

Following gene: 120609718

Centisome position: 20.98

GC content: 67.56

Gene sequence:

>669_bases
ATGACGACCCCGGGCGACGTGATCACCCTGGCCCTGTCCAAGGGCCGCATCTTCGACGAAACCCTCCCGCTGCTGGCAGC
CGCCGGCATCGAGGTGCTGGAAGACCCCGAGAAATCCCGCAAGCTGATCCTGCCGACCAACCGGCCCGAGGTGCGCGTGG
TGCTGGTGCGCGCCACCGACGTGCCCACCTACGTGCAGTACGGCGGCGCGGACCTGGGCGTGACGGGCAAGGACACGCTC
ATCGAGCACGGGGGCCAGGGCCTCTACCAGCCGCTGGACCTGCAGATCGCCAAGTGCCGCGTGAGCGTGGCGGTGCGGCA
GGATTTCGACTACGCCAGCGCCGTGAAGCAGGGGGCCCGCCTCAACGTGGCCACCAAGTACACCACCATCGCCCGCGAGT
TCTTCGCGGCCAAGGGCGTACACGTGGACATGATCAAGCTCTACGGCAGCATGGAGCTTGCCCCGCTCACCGGGCTGGCC
GATGCGATCGTGGATCTGGTCTCGACGGGCAGCACGCTGCGCGCCAACCACCTGGTGGAAGTGGAGCGCATCATGGACAT
CAGCTCGCATCTCGTGGTGAACCAGGCCGCGCTCAAGCTCAAGCGCGAGCCGTTGCGCCGCATCATCGATGCGTTCGCCC
AGGCTACCGCTGCAGGCGCCCCGAAGTGA

Upstream 100 bases:

>100_bases
GCCAGACCACGGTGGACCGCATCTACCACCTCGACCGCGGCTACGACTGCATGGAAGGCAAGCTGCGCGCCCTGGGCGCC
GATATCGAAAGGGTGAAGGC

Downstream 100 bases:

>100_bases
AAGTCGGGCGCGTGTGATACGAGAGATCGCTGCCATCCATTGATACTATGAAATTAATAGCTGCTCCTGCCCGTCTCTCC
ACGGTATCCGCTACCTTCGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTTPGDVITLALSKGRIFDETLPLLAAAGIEVLEDPEKSRKLILPTNRPEVRVVLVRATDVPTYVQYGGADLGVTGKDTL
IEHGGQGLYQPLDLQIAKCRVSVAVRQDFDYASAVKQGARLNVATKYTTIAREFFAAKGVHVDMIKLYGSMELAPLTGLA
DAIVDLVSTGSTLRANHLVEVERIMDISSHLVVNQAALKLKREPLRRIIDAFAQATAAGAPK

Sequences:

>Translated_222_residues
MTTPGDVITLALSKGRIFDETLPLLAAAGIEVLEDPEKSRKLILPTNRPEVRVVLVRATDVPTYVQYGGADLGVTGKDTL
IEHGGQGLYQPLDLQIAKCRVSVAVRQDFDYASAVKQGARLNVATKYTTIAREFFAAKGVHVDMIKLYGSMELAPLTGLA
DAIVDLVSTGSTLRANHLVEVERIMDISSHLVVNQAALKLKREPLRRIIDAFAQATAAGAPK
>Mature_221_residues
TTPGDVITLALSKGRIFDETLPLLAAAGIEVLEDPEKSRKLILPTNRPEVRVVLVRATDVPTYVQYGGADLGVTGKDTLI
EHGGQGLYQPLDLQIAKCRVSVAVRQDFDYASAVKQGARLNVATKYTTIAREFFAAKGVHVDMIKLYGSMELAPLTGLAD
AIVDLVSTGSTLRANHLVEVERIMDISSHLVVNQAALKLKREPLRRIIDAFAQATAAGAPK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=207, Percent_Identity=32.8502415458937, Blast_Score=91, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=187, Percent_Identity=31.0160427807487, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_ACIAC (A1TKY3)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969395.1
- ProteinModelPortal:   A1TKY3
- SMR:   A1TKY3
- STRING:   A1TKY3
- GeneID:   4669723
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_1023
- NMPDR:   fig|397945.5.peg.891
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- PhylomeDB:   A1TKY3
- ProtClustDB:   PRK01686
- BioCyc:   AAVE397945:AAVE_1023-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23946; Mature: 23815

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPGDVITLALSKGRIFDETLPLLAAAGIEVLEDPEKSRKLILPTNRPEVRVVLVRATD
CCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHCCCCCCCEEEECCCCCCEEEEEEEECC
VPTYVQYGGADLGVTGKDTLIEHGGQGLYQPLDLQIAKCRVSVAVRQDFDYASAVKQGAR
CCHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEHHEEEEEECCCCCHHHHHHCCCE
LNVATKYTTIAREFFAAKGVHVDMIKLYGSMELAPLTGLADAIVDLVSTGSTLRANHLVE
EEEEHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
VERIMDISSHLVVNQAALKLKREPLRRIIDAFAQATAAGAPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTPGDVITLALSKGRIFDETLPLLAAAGIEVLEDPEKSRKLILPTNRPEVRVVLVRATD
CCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHCCCCCCCEEEECCCCCCEEEEEEEECC
VPTYVQYGGADLGVTGKDTLIEHGGQGLYQPLDLQIAKCRVSVAVRQDFDYASAVKQGAR
CCHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCEEEHHEEEEEECCCCCHHHHHHCCCE
LNVATKYTTIAREFFAAKGVHVDMIKLYGSMELAPLTGLADAIVDLVSTGSTLRANHLVE
EEEEHHHHHHHHHHHHHCCCEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
VERIMDISSHLVVNQAALKLKREPLRRIIDAFAQATAAGAPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA