Click here to switch to the map view.

The map label for this gene is htrB [H]

Identifier: 120609675

GI number: 120609675

Start: 1077102

End: 1077974

Strand: Direct

Name: htrB [H]

Synonym: Aave_0981

Alternate gene names: 120609675

Gene position: 1077102-1077974 (Clockwise)

Preceding gene: 120609674

Following gene: 120609678

Centisome position: 20.12

GC content: 68.27

Gene sequence:

>873_bases
ATGACGGCGGGGCGCTTCAATCTCGCCTGCATGCGCGTGCTCGCCCGCCTGCCCCTGCCCGTGCTGCGGGCCCTGGGCTG
GGTGCTGGGGCAGGTGATCTACGTGCTGGCCAAGCCGCGTCGCAAGATAGCGCTGCGCAACCTGGAGCTGTGCTTTCCCG
AGGCGAGCGCCGCGCAGCGGCGAGCGTGGGCGCGCGAAACCTTCGTGCGCTTCTGCCAGGCCTGGCTGGACCGCAGCTGG
CTCTGGATGGCACCACGGTCGGTGGTGGAAAAGCGCCTGGAAATCCACGGCGCGCTCGACGAACTCGAAGGCGATACACC
CACGATCATCCTGGCGCCGCATTTCCTGGGCATGGACGCCGCGGGAACCGCGCTCACGCTGCAGACCGACCGGGCCTTCA
CCTCCATCTTCACCCCGCATCCCGATCCGGACATCGATGCCTGGCTGTTCGCGGGCCGCCAGCGCTTCGGCAACGTGCGC
ATGCTCAACCGGGGAGACGGCGTCAAGCCCATCCTGAGCGGGCTGCGCAAGGGGGGGCTGCTGTACCTGCTGCCGGACAT
GGATTTCGGGCCCAACGACTCGGTGTTCGTGCCCTTCTACGGCATGTCGGCCGCCACCATCACTTCGCTGTCGCGCTTCG
CGCGGCTGGGCCGGGCCAAGGTGGTGCCGCTCATCGGGCGCATCACGCCGCGCGGCTACAGCGCGGAAATGATGCCGGCC
TGGCAGAACTACCCCACCGACGACATCGAGGCCGACACCGCCCGCATGAACCGCGAACTGCAGCAGTGGATCGACACCAT
GCCGGGCCAGTATTACTGGGTGCACCGGCGCTTCAAGTCGCGTCCTGCGGGCGAGCCGTCCGTCTATCGCTGA

Upstream 100 bases:

>100_bases
GCATCATCCGACACTCTCCCGACCAATACCTCTGGGGCTACGGGCGCTACAAGCAACCGCGGGCCGAGGCATCCACGCCG
GCCGTGCCGGGAGCGGACGC

Downstream 100 bases:

>100_bases
AGCCGGCCGACCGCTGCCGTGCCTGGCAGCGGCAGCTACTGCTGGCGCGTCTCCTTCAGGAAATCCCCGATCTCGCGCGC
CACGCGCTCCGGCTGCTCGT

Product: lipid A biosynthesis acyltransferase

Products: NA

Alternate protein names: Heat shock protein B [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTAGRFNLACMRVLARLPLPVLRALGWVLGQVIYVLAKPRRKIALRNLELCFPEASAAQRRAWARETFVRFCQAWLDRSW
LWMAPRSVVEKRLEIHGALDELEGDTPTIILAPHFLGMDAAGTALTLQTDRAFTSIFTPHPDPDIDAWLFAGRQRFGNVR
MLNRGDGVKPILSGLRKGGLLYLLPDMDFGPNDSVFVPFYGMSAATITSLSRFARLGRAKVVPLIGRITPRGYSAEMMPA
WQNYPTDDIEADTARMNRELQQWIDTMPGQYYWVHRRFKSRPAGEPSVYR

Sequences:

>Translated_290_residues
MTAGRFNLACMRVLARLPLPVLRALGWVLGQVIYVLAKPRRKIALRNLELCFPEASAAQRRAWARETFVRFCQAWLDRSW
LWMAPRSVVEKRLEIHGALDELEGDTPTIILAPHFLGMDAAGTALTLQTDRAFTSIFTPHPDPDIDAWLFAGRQRFGNVR
MLNRGDGVKPILSGLRKGGLLYLLPDMDFGPNDSVFVPFYGMSAATITSLSRFARLGRAKVVPLIGRITPRGYSAEMMPA
WQNYPTDDIEADTARMNRELQQWIDTMPGQYYWVHRRFKSRPAGEPSVYR
>Mature_289_residues
TAGRFNLACMRVLARLPLPVLRALGWVLGQVIYVLAKPRRKIALRNLELCFPEASAAQRRAWARETFVRFCQAWLDRSWL
WMAPRSVVEKRLEIHGALDELEGDTPTIILAPHFLGMDAAGTALTLQTDRAFTSIFTPHPDPDIDAWLFAGRQRFGNVRM
LNRGDGVKPILSGLRKGGLLYLLPDMDFGPNDSVFVPFYGMSAATITSLSRFARLGRAKVVPLIGRITPRGYSAEMMPAW
QNYPTDDIEADTARMNRELQQWIDTMPGQYYWVHRRFKSRPAGEPSVYR

Specific function: Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA. Has 10 fold selectivity for lauroyl- ACP over myristoyl-ACP [H]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI1787292, Length=290, Percent_Identity=34.1379310344828, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87082094, Length=291, Percent_Identity=31.9587628865979, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788161, Length=276, Percent_Identity=30.7971014492754, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: 2.3.1.-

Molecular weight: Translated: 32924; Mature: 32792

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAGRFNLACMRVLARLPLPVLRALGWVLGQVIYVLAKPRRKIALRNLELCFPEASAAQR
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHH
RAWARETFVRFCQAWLDRSWLWMAPRSVVEKRLEIHGALDELEGDTPTIILAPHFLGMDA
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHCCCC
AGTALTLQTDRAFTSIFTPHPDPDIDAWLFAGRQRFGNVRMLNRGDGVKPILSGLRKGGL
CCCEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCE
LYLLPDMDFGPNDSVFVPFYGMSAATITSLSRFARLGRAKVVPLIGRITPRGYSAEMMPA
EEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCH
WQNYPTDDIEADTARMNRELQQWIDTMPGQYYWVHRRFKSRPAGEPSVYR
HCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TAGRFNLACMRVLARLPLPVLRALGWVLGQVIYVLAKPRRKIALRNLELCFPEASAAQR
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHH
RAWARETFVRFCQAWLDRSWLWMAPRSVVEKRLEIHGALDELEGDTPTIILAPHFLGMDA
HHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHCCCC
AGTALTLQTDRAFTSIFTPHPDPDIDAWLFAGRQRFGNVRMLNRGDGVKPILSGLRKGGL
CCCEEEEECCHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHCCCE
LYLLPDMDFGPNDSVFVPFYGMSAATITSLSRFARLGRAKVVPLIGRITPRGYSAEMMPA
EEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCH
WQNYPTDDIEADTARMNRELQQWIDTMPGQYYWVHRRFKSRPAGEPSVYR
HCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]