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The map label for this gene is murC

Identifier: 120609516

GI number: 120609516

Start: 890439

End: 891866

Strand: Direct

Name: murC

Synonym: Aave_0822

Alternate gene names: 120609516

Gene position: 890439-891866 (Clockwise)

Preceding gene: 120609515

Following gene: 120609517

Centisome position: 16.64

GC content: 71.08

Gene sequence:

>1428_bases
ATGAAGCACGCCATCCGCCACATCCATTTCGTGGGACTCGGGGGCGCCGGCATGTGCGGCATCGCCGAAGTGCTGTTCAA
CCTGGGCTACGAGATCTCGGGCTCCGACCTCGCCGACAGCGCCACGCTGCGCCGCCTGGCCGCGCTGGGCATCGCCACCC
GCGTGGGCCATGCGGCCGCGCACATCGAGGGCGCCGACGCGGTGGTCACCTCCACCGCCGTGCAGTCCGACAACCCCGAG
GTGATCGCCGCGCGCGAACGCAAGATTCCCGTGGTGCCGCGCGCCCTGATGCTGGCGGAGCTGATGCGCCTCAAGCGCGG
CATCGCGATCGCCGGCACCCACGGCAAGACCACCACCACCAGCCTCGTGACCAGCGTGCTCGCGGAAGCGGGGCTGGACC
CGACCTTCGTGATCGGCGGGCGCCTCAACAGCGCGGGCGCGAACGCCAAGCTGGGGCAGGGCGAGTACATCGTGGTGGAG
GCCGACGAATCCGATGCGTCCTTCCTCAACCTGCTGCCCGTGATGGCGGTGGTGACGAACATCGACGCCGACCACATGGA
AACCTACGGCCACGACTTCGGCCGGCTGAAGTCGGCCTTCGTGGACTTCCTGCACCGCATGCCGTTCTACGGCACGGCCA
TCCTCTGCACCGACAACCCCGCCATCCGCGAGATCCTGCCCGACGTGACCTGCCCGGTCACGAGCTACGGCTTCTCCGAG
GATGCCCAGGTGCGCGCGGTGGACGTGCGCGCCGACGCGGGCCGCATGCGCTTCCGCGTGCAGCGCCGCAACGGCGTGAC
GCTGCCCGACCTCGACGTGGTGCTGAACCTCGCCGGCGAGCACAACGTGCTCAACGCGCTGTCGGCGATCGCCGTGGCGG
TGGAACTGAACATTCCCGACGAGGCGCTGCTGCGTGCGCTCGCGCAGTTCAAGGGCGTGGGCCGGCGCTTCCAGCGCTAC
GGCGAGCTGCCCGCGCAGGGCGGCGGCACCTTCACCCTGATCGAGGACTACGGCCACCATCCCGTGGAAATGACGGCCAC
GCTCGCCGCGGCGCGCGGCGCGTTCCCGGGCCGCCGCCTCGTGCTGGCCTTCCAGCCGCACCGCTACAGCCGCACACGCG
ACTGTTTCGAGGACTTCGTGAAGGTGATGGGCAGCGCCGACGCCGTGCTGCTCACCGAGGTCTATGCGGCCGGCGAGGCG
CCCATCGTGGCGGCCGACGGCCGTTCGCTCGCCCGCGCGGTGCGCGTGGCCGGGCAGGTGGAGCCCGTCTTCGTGGACGA
CATCGGCGAGCTGCCGCGGCGCATCGCGGACAACGCGCGCGGCGGCGACGTGGTGCTGTGCATGGGGGCCGGCTCGATCG
GCGCCGTGCCCGCGAAGGTGGTGGAGATGCTGCGCACGGACGTGCCGGCGATGCAGGAGGATCGGTGA

Upstream 100 bases:

>100_bases
CGGAGCGCGAAGCGCTGTTGGAGCGCGCGCTGAAAGCCAAGACGATGCAGAAGATCCACGCCACCCGCGAGGTGGCGAAC
GCGTGCGAGGAATTGACCGC

Downstream 100 bases:

>100_bases
TGGCCGCGGGCTTACCTGAAACCGAAATCGACGTGCGGGCGCTGGGCAAGGTGGCCGTGCTGATGGGCGGCGACTCCGCC
GAGCGGGAGGTTTCGCTCAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MKHAIRHIHFVGLGGAGMCGIAEVLFNLGYEISGSDLADSATLRRLAALGIATRVGHAAAHIEGADAVVTSTAVQSDNPE
VIAARERKIPVVPRALMLAELMRLKRGIAIAGTHGKTTTTSLVTSVLAEAGLDPTFVIGGRLNSAGANAKLGQGEYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFGRLKSAFVDFLHRMPFYGTAILCTDNPAIREILPDVTCPVTSYGFSE
DAQVRAVDVRADAGRMRFRVQRRNGVTLPDLDVVLNLAGEHNVLNALSAIAVAVELNIPDEALLRALAQFKGVGRRFQRY
GELPAQGGGTFTLIEDYGHHPVEMTATLAAARGAFPGRRLVLAFQPHRYSRTRDCFEDFVKVMGSADAVLLTEVYAAGEA
PIVAADGRSLARAVRVAGQVEPVFVDDIGELPRRIADNARGGDVVLCMGAGSIGAVPAKVVEMLRTDVPAMQEDR

Sequences:

>Translated_475_residues
MKHAIRHIHFVGLGGAGMCGIAEVLFNLGYEISGSDLADSATLRRLAALGIATRVGHAAAHIEGADAVVTSTAVQSDNPE
VIAARERKIPVVPRALMLAELMRLKRGIAIAGTHGKTTTTSLVTSVLAEAGLDPTFVIGGRLNSAGANAKLGQGEYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFGRLKSAFVDFLHRMPFYGTAILCTDNPAIREILPDVTCPVTSYGFSE
DAQVRAVDVRADAGRMRFRVQRRNGVTLPDLDVVLNLAGEHNVLNALSAIAVAVELNIPDEALLRALAQFKGVGRRFQRY
GELPAQGGGTFTLIEDYGHHPVEMTATLAAARGAFPGRRLVLAFQPHRYSRTRDCFEDFVKVMGSADAVLLTEVYAAGEA
PIVAADGRSLARAVRVAGQVEPVFVDDIGELPRRIADNARGGDVVLCMGAGSIGAVPAKVVEMLRTDVPAMQEDR
>Mature_475_residues
MKHAIRHIHFVGLGGAGMCGIAEVLFNLGYEISGSDLADSATLRRLAALGIATRVGHAAAHIEGADAVVTSTAVQSDNPE
VIAARERKIPVVPRALMLAELMRLKRGIAIAGTHGKTTTTSLVTSVLAEAGLDPTFVIGGRLNSAGANAKLGQGEYIVVE
ADESDASFLNLLPVMAVVTNIDADHMETYGHDFGRLKSAFVDFLHRMPFYGTAILCTDNPAIREILPDVTCPVTSYGFSE
DAQVRAVDVRADAGRMRFRVQRRNGVTLPDLDVVLNLAGEHNVLNALSAIAVAVELNIPDEALLRALAQFKGVGRRFQRY
GELPAQGGGTFTLIEDYGHHPVEMTATLAAARGAFPGRRLVLAFQPHRYSRTRDCFEDFVKVMGSADAVLLTEVYAAGEA
PIVAADGRSLARAVRVAGQVEPVFVDDIGELPRRIADNARGGDVVLCMGAGSIGAVPAKVVEMLRTDVPAMQEDR

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=474, Percent_Identity=51.4767932489451, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1790680, Length=481, Percent_Identity=28.8981288981289, Blast_Score=161, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_ACIAC (A1TKD2)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969194.1
- ProteinModelPortal:   A1TKD2
- SMR:   A1TKD2
- STRING:   A1TKD2
- GeneID:   4668633
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0822
- NMPDR:   fig|397945.5.peg.713
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   A1TKD2
- ProtClustDB:   PRK00421
- BioCyc:   AAVE397945:AAVE_0822-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50610; Mature: 50610

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAIRHIHFVGLGGAGMCGIAEVLFNLGYEISGSDLADSATLRRLAALGIATRVGHAAA
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HIEGADAVVTSTAVQSDNPEVIAARERKIPVVPRALMLAELMRLKRGIAIAGTHGKTTTT
HCCCCCCEEEEHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHH
SLVTSVLAEAGLDPTFVIGGRLNSAGANAKLGQGEYIVVEADESDASFLNLLPVMAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
IDADHMETYGHDFGRLKSAFVDFLHRMPFYGTAILCTDNPAIREILPDVTCPVTSYGFSE
CCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCC
DAQVRAVDVRADAGRMRFRVQRRNGVTLPDLDVVLNLAGEHNVLNALSAIAVAVELNIPD
CCEEEEEEEECCCCCEEEEEECCCCCCCCCHHHHEECCCCCHHHHHHHHEEEEEEECCCH
EALLRALAQFKGVGRRFQRYGELPAQGGGTFTLIEDYGHHPVEMTATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VLAFQPHRYSRTRDCFEDFVKVMGSADAVLLTEVYAAGEAPIVAADGRSLARAVRVAGQV
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVDDIGELPRRIADNARGGDVVLCMGAGSIGAVPAKVVEMLRTDVPAMQEDR
CEEEHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKHAIRHIHFVGLGGAGMCGIAEVLFNLGYEISGSDLADSATLRRLAALGIATRVGHAAA
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HIEGADAVVTSTAVQSDNPEVIAARERKIPVVPRALMLAELMRLKRGIAIAGTHGKTTTT
HCCCCCCEEEEHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHH
SLVTSVLAEAGLDPTFVIGGRLNSAGANAKLGQGEYIVVEADESDASFLNLLPVMAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
IDADHMETYGHDFGRLKSAFVDFLHRMPFYGTAILCTDNPAIREILPDVTCPVTSYGFSE
CCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCC
DAQVRAVDVRADAGRMRFRVQRRNGVTLPDLDVVLNLAGEHNVLNALSAIAVAVELNIPD
CCEEEEEEEECCCCCEEEEEECCCCCCCCCHHHHEECCCCCHHHHHHHHEEEEEEECCCH
EALLRALAQFKGVGRRFQRYGELPAQGGGTFTLIEDYGHHPVEMTATLAAARGAFPGRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEE
VLAFQPHRYSRTRDCFEDFVKVMGSADAVLLTEVYAAGEAPIVAADGRSLARAVRVAGQV
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
EPVFVDDIGELPRRIADNARGGDVVLCMGAGSIGAVPAKVVEMLRTDVPAMQEDR
CEEEHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA