Click here to switch to the map view.

The map label for this gene is mraY

Identifier: 120609512

GI number: 120609512

Start: 884837

End: 886015

Strand: Direct

Name: mraY

Synonym: Aave_0818

Alternate gene names: 120609512

Gene position: 884837-886015 (Clockwise)

Preceding gene: 120609511

Following gene: 120609513

Centisome position: 16.53

GC content: 65.48

Gene sequence:

>1179_bases
ATGCTCCTGATGCTCTCCCAGTGGCTGCAGGGCCTGTCGCCCGAATTCGGCTTCTTCCGTGTCTTCCAGTACCTGACCTT
CCGCGCGGTGATGGCGGCCATGACGGCGCTGCTCATCGGGCTCCTGGCGGGCCCGAAGGTGATCCGCATGCTCACCGCGC
TCAAGATCGGCCAGCCGATCCGCGGCTACGCGATGGAGTCGCACCTGTCCAAGAGCGGCACGCCCACCATGGGCGGCGTG
CTCATCCTGGGCGCCATCGCCATCTCCACGCTGCTGTGGTTCGACCTGTCCAACCGCTTCGTCTGGGTGGTGCTGGCCGT
CACCCTGGGCTTCGGCGCCATCGGCTGGGTGGACGACTGGCGCAAGGTCGTGCGCAAGGATCCGGAGGGCATGCGCTCGC
GCGAGAAGTATTTCTGGCAGTCCGTCATCGGCATCGTGGCCGCGCTCTACCTCGTGTTCTGCATCTCCGAGAACTCCAAC
GCGCGCGTGTTCGAGCTGTTCGTCACCTGGATCCAGTCGGGCTTCTCGATGGACCTGCCGCCCCAGGCGGGCCTGCTGGT
GCCGTTCTTCAAGGAAGTGAGCTACCCGCTGGGCGTGCTCGGCTTCGTGATCCTGACCTACCTCGTCATCGTGGGTTCGA
GCAACGCGGTGAACCTGACGGACGGGCTGGACGGCCTCGCGATCATGCCGGTCGTCATGGTGGGCGCGTCCCTCGGCGTC
TTCGCGTACGTGACGGGCAGCGCGGTCTATTCCAAGTACCTGCTCTTCCCCTACATCGCGGGCGCGGGCGAGCTGCTGAT
CTTCTGCTCGGCCATGGCCGGCGCGGGGCTCGCATTCCTGTGGTTCAACACCCATCCGGCCCAGGTATTCATGGGCGACG
TGGGCGCGCTCGCGCTCGGCGGCGCGCTGGGCACCATCGCCATCATCGTGCGCCAGGAAATCGTGCTGGCCATCATGGGC
GGCATCTTCGTGGTCGAGGCGCTCTCGGTGATGCTGCAGGTCACCTGGTTCAAGTACACCAAGCGCCGGTACGGCGAAGG
CCGGCGCCTGCTCAAGATGGCGCCGCTGCACCACCATTTCGAGAAGAGCGGCTGGAAAGAGACGCAGGTCGTCGTGCGTT
TCTGGATCATCACCATGCTGCTGTGCCTGATCGGCCTCACCACGCTCAAGCTGCGATGA

Upstream 100 bases:

>100_bases
CGCTCGAAGCGCCGGACGTGTTGGCGCAGGAACGCCATCGGCCGGACGGCCCGGGCGTGCCGGGCGCGGCGCGCGCCGCC
ATCGCCGGGAGGGACACCGC

Downstream 100 bases:

>100_bases
ACCCGACCGATCGCGACCTCCATCCCGCCACCGGCGCCCTCCTGGACGCCGGTGCCGCGCCATGGCCGCTCCCTGCCGCC
GTGGCGCAGGAGGCGCCCGC

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MLLMLSQWLQGLSPEFGFFRVFQYLTFRAVMAAMTALLIGLLAGPKVIRMLTALKIGQPIRGYAMESHLSKSGTPTMGGV
LILGAIAISTLLWFDLSNRFVWVVLAVTLGFGAIGWVDDWRKVVRKDPEGMRSREKYFWQSVIGIVAALYLVFCISENSN
ARVFELFVTWIQSGFSMDLPPQAGLLVPFFKEVSYPLGVLGFVILTYLVIVGSSNAVNLTDGLDGLAIMPVVMVGASLGV
FAYVTGSAVYSKYLLFPYIAGAGELLIFCSAMAGAGLAFLWFNTHPAQVFMGDVGALALGGALGTIAIIVRQEIVLAIMG
GIFVVEALSVMLQVTWFKYTKRRYGEGRRLLKMAPLHHHFEKSGWKETQVVVRFWIITMLLCLIGLTTLKLR

Sequences:

>Translated_392_residues
MLLMLSQWLQGLSPEFGFFRVFQYLTFRAVMAAMTALLIGLLAGPKVIRMLTALKIGQPIRGYAMESHLSKSGTPTMGGV
LILGAIAISTLLWFDLSNRFVWVVLAVTLGFGAIGWVDDWRKVVRKDPEGMRSREKYFWQSVIGIVAALYLVFCISENSN
ARVFELFVTWIQSGFSMDLPPQAGLLVPFFKEVSYPLGVLGFVILTYLVIVGSSNAVNLTDGLDGLAIMPVVMVGASLGV
FAYVTGSAVYSKYLLFPYIAGAGELLIFCSAMAGAGLAFLWFNTHPAQVFMGDVGALALGGALGTIAIIVRQEIVLAIMG
GIFVVEALSVMLQVTWFKYTKRRYGEGRRLLKMAPLHHHFEKSGWKETQVVVRFWIITMLLCLIGLTTLKLR
>Mature_392_residues
MLLMLSQWLQGLSPEFGFFRVFQYLTFRAVMAAMTALLIGLLAGPKVIRMLTALKIGQPIRGYAMESHLSKSGTPTMGGV
LILGAIAISTLLWFDLSNRFVWVVLAVTLGFGAIGWVDDWRKVVRKDPEGMRSREKYFWQSVIGIVAALYLVFCISENSN
ARVFELFVTWIQSGFSMDLPPQAGLLVPFFKEVSYPLGVLGFVILTYLVIVGSSNAVNLTDGLDGLAIMPVVMVGASLGV
FAYVTGSAVYSKYLLFPYIAGAGELLIFCSAMAGAGLAFLWFNTHPAQVFMGDVGALALGGALGTIAIIVRQEIVLAIMG
GIFVVEALSVMLQVTWFKYTKRRYGEGRRLLKMAPLHHHFEKSGWKETQVVVRFWIITMLLCLIGLTTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=388, Percent_Identity=53.3505154639175, Blast_Score=369, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_ACIAC (A1TKC8)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_969190.1
- STRING:   A1TKC8
- GeneID:   4668576
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_0818
- NMPDR:   fig|397945.5.peg.709
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   TFWQFRN
- PhylomeDB:   A1TKC8
- ProtClustDB:   PRK00108
- BioCyc:   AAVE397945:AAVE_0818-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 43149; Mature: 43149

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1116036c)-; HASH(0x11ef6290)-; HASH(0x107dd454)-; HASH(0xf7c2370)-; HASH(0x11f00a04)-; HASH(0x11b5d290)-; HASH(0x10b4d058)-; HASH(0x11ef3fbc)-; HASH(0x11ae8220)-; HASH(0x11ef6470)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure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HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA