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The map label for this gene is glmU

Identifier: 119946810

GI number: 119946810

Start: 3958845

End: 3960203

Strand: Reverse

Name: glmU

Synonym: Ping_3204

Alternate gene names: 119946810

Gene position: 3960203-3958845 (Counterclockwise)

Preceding gene: 119946813

Following gene: 119946806

Centisome position: 86.85

GC content: 41.87

Gene sequence:

>1359_bases
ATGTCTTTAAGCGTTGTTATCCTTGCCGCCGGCAAAGGAACTCGTATGTGTTCTGAACTTCCCAAAGTGCTCCATAAAAT
AGCAGATAAACCGATGGTTCAACATGTTATTGATACGGTTAAAAGTATAGGTGCTGACAGCATTCATTTGATTTATGGTC
ACGGAGGGCAACAGCTGCAGGAAAAAATATCCGATGGCAGTCTTAATTGGATCAAACAAGCCGAGCAATTAGGCACCGGC
CATGCGATGCAAATTGCACTGCCTCATTTTAAAAATGATGAAAAAATTCTAATGGTTTATGGTGATGTGCCCTTGCTTTC
TGAAAAAACATTAACAGATTTAATCGCGGCACAACCGCCTGGTGGTATCGGATTATTAACCGTTGAGCTAGATAATCCAA
CAGGTTATGGACGTATTGAACGGATGAATGGCGAGGTTGCTGGTATTGTTGAGCAAAAAGACGCGACAGTAGCGCAATTA
AGCATTAAAGAGGTCAATACAGGCATTCTTGTTGCGGATGCCAATGATTTAAGTCGTTGGCTGCCTGCGTTAAGTAATGA
AAATGCGGCTGGTGAATATTATATTACTGATATTATTAAAATGGCGCATTTAGAGGGACGCATTATCTCTGCTGTCCAAC
CAGAAAGTGCAACTGAAGTTGAAGGTGTTAATACTCGCCTGCAACTTGCCAATCTAGAGCGTGCTTATCAGCTTAAAAAA
GCGACTGAACTGCTGCTCAGTGGTGTGATGCTGCGAGATCCAAACCGCTTTGATTTACGCGGAACATTAACTTGCGGTGT
AGATGTTGAAATTGATATCAATGTTATTATCCAGGGTAATGTTAATTTGGGTAACGGTGTTGTGATTGGCGCAAACTGTA
TTCTTATTGATTGTGATATCGCTGAGAATGCTGTGATCCAGGCTAATTCAATTATCGAAGGCAGTAGTATTGGCGCCCGT
GCAACGATCGGTCCATTTGCTCGTATTCGTCCCCAAAGTGTGCTTAAAGAAGAAGTGCATGTCGGTAACTTTGTTGAGAT
TAAAAAATCAACCCTGGGTAATGGCACTAAATGTGGCCATTTAAGTTATATAGGGGACAGCACATTAGGTCAAAGGGTTA
ATATTGGTGCAGGTACTATCACTTGTAATTATGATGGCGTGAACAAATTCCATACTCATATTGGCGACGATGTCTTTATT
GGATCCGACTGTCAGTTGATCGCACCTGTTACCATCAATAACGGGGCAACAACGGGTGCCGGTTCAACCATAATGATCGA
CGTACCAGAGAATGCATTAGCAATTGGTCGTGCTAAACAGCGTAATATTAATAACTGGAAGCGGCCAACTAAAAAATAA

Upstream 100 bases:

>100_bases
ATTCAGTAATAAAATACGAGCATGTCATTTTATTATTCGTTAAAGGTAAAAACTTCGTTAGAATGGTATCTTTAATTTTT
TAATTATTGAGGTTTTCTCT

Downstream 100 bases:

>100_bases
GCCTATTACAGTCAACATTAGTGGGGTAAACATTGCTTTACCTCACTTAATTATTCAGTCCCTTTTATCTCATCTAATTC
TTTTATATGCTTATGTATTT

Product: fused N-acetyl glucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSLSVVILAAGKGTRMCSELPKVLHKIADKPMVQHVIDTVKSIGADSIHLIYGHGGQQLQEKISDGSLNWIKQAEQLGTG
HAMQIALPHFKNDEKILMVYGDVPLLSEKTLTDLIAAQPPGGIGLLTVELDNPTGYGRIERMNGEVAGIVEQKDATVAQL
SIKEVNTGILVADANDLSRWLPALSNENAAGEYYITDIIKMAHLEGRIISAVQPESATEVEGVNTRLQLANLERAYQLKK
ATELLLSGVMLRDPNRFDLRGTLTCGVDVEIDINVIIQGNVNLGNGVVIGANCILIDCDIAENAVIQANSIIEGSSIGAR
ATIGPFARIRPQSVLKEEVHVGNFVEIKKSTLGNGTKCGHLSYIGDSTLGQRVNIGAGTITCNYDGVNKFHTHIGDDVFI
GSDCQLIAPVTINNGATTGAGSTIMIDVPENALAIGRAKQRNINNWKRPTKK

Sequences:

>Translated_452_residues
MSLSVVILAAGKGTRMCSELPKVLHKIADKPMVQHVIDTVKSIGADSIHLIYGHGGQQLQEKISDGSLNWIKQAEQLGTG
HAMQIALPHFKNDEKILMVYGDVPLLSEKTLTDLIAAQPPGGIGLLTVELDNPTGYGRIERMNGEVAGIVEQKDATVAQL
SIKEVNTGILVADANDLSRWLPALSNENAAGEYYITDIIKMAHLEGRIISAVQPESATEVEGVNTRLQLANLERAYQLKK
ATELLLSGVMLRDPNRFDLRGTLTCGVDVEIDINVIIQGNVNLGNGVVIGANCILIDCDIAENAVIQANSIIEGSSIGAR
ATIGPFARIRPQSVLKEEVHVGNFVEIKKSTLGNGTKCGHLSYIGDSTLGQRVNIGAGTITCNYDGVNKFHTHIGDDVFI
GSDCQLIAPVTINNGATTGAGSTIMIDVPENALAIGRAKQRNINNWKRPTKK
>Mature_451_residues
SLSVVILAAGKGTRMCSELPKVLHKIADKPMVQHVIDTVKSIGADSIHLIYGHGGQQLQEKISDGSLNWIKQAEQLGTGH
AMQIALPHFKNDEKILMVYGDVPLLSEKTLTDLIAAQPPGGIGLLTVELDNPTGYGRIERMNGEVAGIVEQKDATVAQLS
IKEVNTGILVADANDLSRWLPALSNENAAGEYYITDIIKMAHLEGRIISAVQPESATEVEGVNTRLQLANLERAYQLKKA
TELLLSGVMLRDPNRFDLRGTLTCGVDVEIDINVIIQGNVNLGNGVVIGANCILIDCDIAENAVIQANSIIEGSSIGARA
TIGPFARIRPQSVLKEEVHVGNFVEIKKSTLGNGTKCGHLSYIGDSTLGQRVNIGAGTITCNYDGVNKFHTHIGDDVFIG
SDCQLIAPVTINNGATTGAGSTIMIDVPENALAIGRAKQRNINNWKRPTKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=62.0842572062084, Blast_Score=575, Evalue=1e-165,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_PSYIN (A1SZH6)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_944490.1
- ProteinModelPortal:   A1SZH6
- SMR:   A1SZH6
- STRING:   A1SZH6
- GeneID:   4624813
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_3204
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A1SZH6
- BioCyc:   PING357804:PING_3204-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48414; Mature: 48283

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 360-360 BINDING 73-73 BINDING 137-137 BINDING 151-151 BINDING 166-166 BINDING 384-384 BINDING 402-402 BINDING 420-420 BINDING 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSVVILAAGKGTRMCSELPKVLHKIADKPMVQHVIDTVKSIGADSIHLIYGHGGQQLQ
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
EKISDGSLNWIKQAEQLGTGHAMQIALPHFKNDEKILMVYGDVPLLSEKTLTDLIAAQPP
HHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCC
GGIGLLTVELDNPTGYGRIERMNGEVAGIVEQKDATVAQLSIKEVNTGILVADANDLSRW
CCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCEEEEEEEEECCCCEEEECCHHHHHH
LPALSNENAAGEYYITDIIKMAHLEGRIISAVQPESATEVEGVNTRLQLANLERAYQLKK
HHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHH
ATELLLSGVMLRDPNRFDLRGTLTCGVDVEIDINVIIQGNVNLGNGVVIGANCILIDCDI
HHHHHHCCCEEECCCCEEEEEEEEEEEEEEEEEEEEEECCCCCCCCEEEECEEEEEECCC
AENAVIQANSIIEGSSIGARATIGPFARIRPQSVLKEEVHVGNFVEIKKSTLGNGTKCGH
CCCCEEEECCEECCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEHHHCCCCCCCCE
LSYIGDSTLGQRVNIGAGTITCNYDGVNKFHTHIGDDVFIGSDCQLIAPVTINNGATTGA
EEECCCCCCCCEEECCCEEEEEECCCCHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCC
GSTIMIDVPENALAIGRAKQRNINNWKRPTKK
CCEEEEECCCCCEEECCHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SLSVVILAAGKGTRMCSELPKVLHKIADKPMVQHVIDTVKSIGADSIHLIYGHGGQQLQ
CEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHH
EKISDGSLNWIKQAEQLGTGHAMQIALPHFKNDEKILMVYGDVPLLSEKTLTDLIAAQPP
HHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCC
GGIGLLTVELDNPTGYGRIERMNGEVAGIVEQKDATVAQLSIKEVNTGILVADANDLSRW
CCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCEEEEEEEEECCCCEEEECCHHHHHH
LPALSNENAAGEYYITDIIKMAHLEGRIISAVQPESATEVEGVNTRLQLANLERAYQLKK
HHHHCCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHHH
ATELLLSGVMLRDPNRFDLRGTLTCGVDVEIDINVIIQGNVNLGNGVVIGANCILIDCDI
HHHHHHCCCEEECCCCEEEEEEEEEEEEEEEEEEEEEECCCCCCCCEEEECEEEEEECCC
AENAVIQANSIIEGSSIGARATIGPFARIRPQSVLKEEVHVGNFVEIKKSTLGNGTKCGH
CCCCEEEECCEECCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCEEEEEHHHCCCCCCCCE
LSYIGDSTLGQRVNIGAGTITCNYDGVNKFHTHIGDDVFIGSDCQLIAPVTINNGATTGA
EEECCCCCCCCEEECCCEEEEEECCCCHHHHHHCCCCEEECCCCEEEEEEEECCCCCCCC
GSTIMIDVPENALAIGRAKQRNINNWKRPTKK
CCEEEEECCCCCEEECCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA