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The map label for this gene is bioF [H]

Identifier: 119945614

GI number: 119945614

Start: 2348671

End: 2349849

Strand: Reverse

Name: bioF [H]

Synonym: Ping_1923

Alternate gene names: 119945614

Gene position: 2349849-2348671 (Counterclockwise)

Preceding gene: 119945615

Following gene: 119945613

Centisome position: 51.54

GC content: 43.43

Gene sequence:

>1179_bases
ATGGCATTTGATTTTATTACTGAGCAACTAGCTGAGCGCCATCGACAGGGGTTGTATCGCTGCTCAACCAGTATGTCGGG
TGCACAGGGCCGTTTGCTTCATGTTGCCGATAAAACCTACTTAAATTTTTCAAGCAATGATTATTTAGGGATGGCGGCGG
ATCCAAAGCTTATCAAAGCCTGGCAGAAGGGGGCTGAGCTTTACGGTATAGGAAGTGGCGGCTCTTATCTGGTGACCGGG
TTTAACCAGACACATCAGGCACTGTGTGATCAGCTGAAATTATGGTTAGGAGTTGAATCCGTCGCCCTGTTTAGCTCCGG
TTATTCGGCTAATCAGGCGATTATCAAACTGCTTCTGAAAAAACCGGATCTGTTATTTCAGGATAAGCTTAATCACGCCT
CCTTAATGGAAGCTGCGCTTTTATCTGATTGTACAATGCGACGTTTTAAGCACAATAATGTGGATCATCTGGAAAGTTTG
TTAAGTATTAGCAATAAGAGCAGTACGCTTGATGGCAATAAGTTAATTATCAGTGAAGGCGTCTTTAGCATGGACGGTGA
TACCGCCCCGGTTAATACTTTACATGCAACGGCTAAAAAATATGATGCCTGGTTAATGATTGATGATGCCCACGGTTTAG
GGGTAGTAGGTGAAAATGGTAAAGGCAGCGTGGAGGCTTGTGGTATTGCTAATAAGAATCTACAAATATATATGGCAACG
TTCGGTAAAGCGTTAGGCGTTGGCGGCGCTTTTGTTGCGGGCAGTAAAGAGTTGATAAATTATATTAACAATTTTTCTAA
ACCCTATATTTACAGCACCGGCCTGCCTCCTGCGATGGCTTATACCATTACTCAAGCTGCAAAAATGGCAGAAACACAGG
ATTGGCGGCGTGATAAATTGCAGGTGTTAATAACCACCTTTAGAAAGACAGCAACAAACTTGGGTATCAGCCTGACAGAC
TCGCAGACGGCTATTCAGCCTATTATTATTGGAGACAGTGTTAAAACGCTGCAGATAGCGGATAAATTAAAAACCCTTGG
ATTTTGGACGACGGCTATTCGTCCTCCTACTGTGGCTGTCGGTACCGCCCGGTTAAGAATTACATTAACAGTAAATCACG
AAGAGAATGATGTTGTGCAGTTAGTTAATGCAATATACCGGGTGCTTAATGACAAATAG

Upstream 100 bases:

>100_bases
TTTCTCTCCCTCTGAAGCTGAAAAAAAGGTGGATGCCGCGATCGTACGTTTTAATGAAAAAGATGAGCTGTTTTTTGACG
CTACCAGTAAAGCATAAACC

Downstream 100 bases:

>100_bases
TATGAAGTTCAATATAAATAAAATACTGGTAGTTAACTCCTTAACAGTGAATGGAATATATAGAGCGCTTCATGACAAAT
AGTGTGAAATTTACAATAGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MAFDFITEQLAERHRQGLYRCSTSMSGAQGRLLHVADKTYLNFSSNDYLGMAADPKLIKAWQKGAELYGIGSGGSYLVTG
FNQTHQALCDQLKLWLGVESVALFSSGYSANQAIIKLLLKKPDLLFQDKLNHASLMEAALLSDCTMRRFKHNNVDHLESL
LSISNKSSTLDGNKLIISEGVFSMDGDTAPVNTLHATAKKYDAWLMIDDAHGLGVVGENGKGSVEACGIANKNLQIYMAT
FGKALGVGGAFVAGSKELINYINNFSKPYIYSTGLPPAMAYTITQAAKMAETQDWRRDKLQVLITTFRKTATNLGISLTD
SQTAIQPIIIGDSVKTLQIADKLKTLGFWTTAIRPPTVAVGTARLRITLTVNHEENDVVQLVNAIYRVLNDK

Sequences:

>Translated_392_residues
MAFDFITEQLAERHRQGLYRCSTSMSGAQGRLLHVADKTYLNFSSNDYLGMAADPKLIKAWQKGAELYGIGSGGSYLVTG
FNQTHQALCDQLKLWLGVESVALFSSGYSANQAIIKLLLKKPDLLFQDKLNHASLMEAALLSDCTMRRFKHNNVDHLESL
LSISNKSSTLDGNKLIISEGVFSMDGDTAPVNTLHATAKKYDAWLMIDDAHGLGVVGENGKGSVEACGIANKNLQIYMAT
FGKALGVGGAFVAGSKELINYINNFSKPYIYSTGLPPAMAYTITQAAKMAETQDWRRDKLQVLITTFRKTATNLGISLTD
SQTAIQPIIIGDSVKTLQIADKLKTLGFWTTAIRPPTVAVGTARLRITLTVNHEENDVVQLVNAIYRVLNDK
>Mature_391_residues
AFDFITEQLAERHRQGLYRCSTSMSGAQGRLLHVADKTYLNFSSNDYLGMAADPKLIKAWQKGAELYGIGSGGSYLVTGF
NQTHQALCDQLKLWLGVESVALFSSGYSANQAIIKLLLKKPDLLFQDKLNHASLMEAALLSDCTMRRFKHNNVDHLESLL
SISNKSSTLDGNKLIISEGVFSMDGDTAPVNTLHATAKKYDAWLMIDDAHGLGVVGENGKGSVEACGIANKNLQIYMATF
GKALGVGGAFVAGSKELINYINNFSKPYIYSTGLPPAMAYTITQAAKMAETQDWRRDKLQVLITTFRKTATNLGISLTDS
QTAIQPIIIGDSVKTLQIADKLKTLGFWTTAIRPPTVAVGTARLRITLTVNHEENDVVQLVNAIYRVLNDK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=370, Percent_Identity=28.3783783783784, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=28.3667621776504, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI83977442, Length=357, Percent_Identity=30.2521008403361, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI83977440, Length=357, Percent_Identity=30.2521008403361, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI83977444, Length=357, Percent_Identity=30.2521008403361, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI119220554, Length=349, Percent_Identity=30.3724928366762, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4758668, Length=397, Percent_Identity=28.9672544080605, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4502025, Length=334, Percent_Identity=29.6407185628743, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI40316939, Length=334, Percent_Identity=29.6407185628743, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI5454084, Length=259, Percent_Identity=26.2548262548263, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=47.6323119777159, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1790046, Length=385, Percent_Identity=32.7272727272727, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71994529, Length=388, Percent_Identity=30.9278350515464, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=375, Percent_Identity=26.1333333333333, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17560914, Length=304, Percent_Identity=28.6184210526316, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=304, Percent_Identity=28.6184210526316, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=269, Percent_Identity=24.5353159851301, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=269, Percent_Identity=24.5353159851301, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=32.8947368421053, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6320267, Length=286, Percent_Identity=30.4195804195804, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=27.1375464684015, Blast_Score=106, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=30.4123711340206, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137420, Length=394, Percent_Identity=30.2030456852792, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI17136286, Length=390, Percent_Identity=27.6923076923077, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24653280, Length=278, Percent_Identity=26.6187050359712, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24653276, Length=278, Percent_Identity=26.6187050359712, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24653278, Length=278, Percent_Identity=26.6187050359712, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 42834; Mature: 42702

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDFITEQLAERHRQGLYRCSTSMSGAQGRLLHVADKTYLNFSSNDYLGMAADPKLIKA
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCEEEECCCHHHHHH
WQKGAELYGIGSGGSYLVTGFNQTHQALCDQLKLWLGVESVALFSSGYSANQAIIKLLLK
HHCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHC
KPDLLFQDKLNHASLMEAALLSDCTMRRFKHNNVDHLESLLSISNKSSTLDGNKLIISEG
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEECC
VFSMDGDTAPVNTLHATAKKYDAWLMIDDAHGLGVVGENGKGSVEACGIANKNLQIYMAT
EEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCEEEEEECCCCCEEEEEE
FGKALGVGGAFVAGSKELINYINNFSKPYIYSTGLPPAMAYTITQAAKMAETQDWRRDKL
HHHHHCCCCCEECCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVLITTFRKTATNLGISLTDSQTAIQPIIIGDSVKTLQIADKLKTLGFWTTAIRPPTVAV
HHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHEEEECCCCCEEEE
GTARLRITLTVNHEENDVVQLVNAIYRVLNDK
EEEEEEEEEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFDFITEQLAERHRQGLYRCSTSMSGAQGRLLHVADKTYLNFSSNDYLGMAADPKLIKA
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCEEEECCCHHHHHH
WQKGAELYGIGSGGSYLVTGFNQTHQALCDQLKLWLGVESVALFSSGYSANQAIIKLLLK
HHCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHC
KPDLLFQDKLNHASLMEAALLSDCTMRRFKHNNVDHLESLLSISNKSSTLDGNKLIISEG
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEECC
VFSMDGDTAPVNTLHATAKKYDAWLMIDDAHGLGVVGENGKGSVEACGIANKNLQIYMAT
EEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEECCCCCCCEEEEEECCCCCEEEEEE
FGKALGVGGAFVAGSKELINYINNFSKPYIYSTGLPPAMAYTITQAAKMAETQDWRRDKL
HHHHHCCCCCEECCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
QVLITTFRKTATNLGISLTDSQTAIQPIIIGDSVKTLQIADKLKTLGFWTTAIRPPTVAV
HHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHEEEECCCCCEEEE
GTARLRITLTVNHEENDVVQLVNAIYRVLNDK
EEEEEEEEEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA