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The map label for this gene is gmd [H]

Identifier: 119944536

GI number: 119944536

Start: 969100

End: 970227

Strand: Direct

Name: gmd [H]

Synonym: Ping_0770

Alternate gene names: 119944536

Gene position: 969100-970227 (Clockwise)

Preceding gene: 119944535

Following gene: 119944537

Centisome position: 21.25

GC content: 39.89

Gene sequence:

>1128_bases
ATGACACAAAATAAAGTTGCATTAATTACAGGTGTTACCGGCCAAGATGGCTCTTACCTTGCTGAATTGTTATTAGAAAA
GGGCTATGAAGTGCACGGTATCAAACGCCGTTCTTCATCATTAAATACCGAACGTGTTGACCATATTTATGAAGATAACC
ATGAACAAAATCAAAAATTCTTTCTGCATTATGGCGATTTAACCGATTCATCTAATTTAACGCGTATTATTAACGATGTA
CAACCAGATGAACTGTACAATCTTGGTGCACAATCTCACGTTGCCGTTTCTTTTGAATGTCCTGAATATACGGCTGACGT
TGATGCGATGGGAACATTACGTTTATTAGAGGCAATTCGCTTTTTAGGGCTGGAAAAGAAAACAAAATTCTATCAGGCAT
CAACTTCAGAGCTGTTTGGCGAAGTACAAGAAATTCCGCAAAAAGAAACAACCCCATTTCACCCTCGTTCACCTTATGGT
GTCGCTAAAATGTACGCTTATTGGATAGTGGTTAATTACCGTGAATCTTATGGTATGTATGCCTGTAACGGTATTTTATT
TAACCATGAGTCACCTCGTCGTGGTGAGACTTTTGTTACCCGTAAAATAACCCGTGCTATTGCTAATATTTCTCAAGGTT
TTGAAAAATGTTTATATCTTGGAAATATGGATGCACTGCGCGATTGGGGGCATGCAAAAGATTACGTGCGTATGCAGTGG
ATGATGTTACAGCAAGAAACAGCTGATGATTTTGTTATTGCAACGGGCAAACAAATCAGTGTGCGTGAATTTGTGACATT
ATCAGCGATCGAGGCGGGTATTGAACTTGAATTCACAGGTAAGGGACTTGATGAAATTGCAACGGTGAAATCTATTACTG
GTGATAACGCACCCGCTCTAAAAGTAGGTGATGTGATAGTGAAAGTTGATCCACGTTATTTCCGTCCCGCTGAAGTTGAA
ACGCTACTAGGTGATCCGTCAAAAGCAAAAGAAAAATTGGGTTGGACGCCAGAAATTACGGTTGAAGAGATGTGCGCTGA
AATGGTCACTAACGACTTACAAAAAGCGAAGCAGCATGCGATTTTGCAAGCACATGGTTTCAAAGTGAATGTATCCGTAG
AATCTTAG

Upstream 100 bases:

>100_bases
ATCTCTCTTTGTAAATAATGTTTTAGGCTGGTTTTTATTTTAAATTAGCTGATAGCCTTTAATCTTTAGGTCTTAGTTTT
AAAAATATTTAGGAAAGTTC

Downstream 100 bases:

>100_bases
ATATATAGAGCACAAGAATTTAACCACCGAGGACACCGAGAGCACAGAGAAAATATGATTATCTATTTTAAAATTTCGGT
AGTTAAAGGATTGAATATTA

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase; ORF13.7 [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTQNKVALITGVTGQDGSYLAELLLEKGYEVHGIKRRSSSLNTERVDHIYEDNHEQNQKFFLHYGDLTDSSNLTRIINDV
QPDELYNLGAQSHVAVSFECPEYTADVDAMGTLRLLEAIRFLGLEKKTKFYQASTSELFGEVQEIPQKETTPFHPRSPYG
VAKMYAYWIVVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANISQGFEKCLYLGNMDALRDWGHAKDYVRMQW
MMLQQETADDFVIATGKQISVREFVTLSAIEAGIELEFTGKGLDEIATVKSITGDNAPALKVGDVIVKVDPRYFRPAEVE
TLLGDPSKAKEKLGWTPEITVEEMCAEMVTNDLQKAKQHAILQAHGFKVNVSVES

Sequences:

>Translated_375_residues
MTQNKVALITGVTGQDGSYLAELLLEKGYEVHGIKRRSSSLNTERVDHIYEDNHEQNQKFFLHYGDLTDSSNLTRIINDV
QPDELYNLGAQSHVAVSFECPEYTADVDAMGTLRLLEAIRFLGLEKKTKFYQASTSELFGEVQEIPQKETTPFHPRSPYG
VAKMYAYWIVVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANISQGFEKCLYLGNMDALRDWGHAKDYVRMQW
MMLQQETADDFVIATGKQISVREFVTLSAIEAGIELEFTGKGLDEIATVKSITGDNAPALKVGDVIVKVDPRYFRPAEVE
TLLGDPSKAKEKLGWTPEITVEEMCAEMVTNDLQKAKQHAILQAHGFKVNVSVES
>Mature_374_residues
TQNKVALITGVTGQDGSYLAELLLEKGYEVHGIKRRSSSLNTERVDHIYEDNHEQNQKFFLHYGDLTDSSNLTRIINDVQ
PDELYNLGAQSHVAVSFECPEYTADVDAMGTLRLLEAIRFLGLEKKTKFYQASTSELFGEVQEIPQKETTPFHPRSPYGV
AKMYAYWIVVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANISQGFEKCLYLGNMDALRDWGHAKDYVRMQWM
MLQQETADDFVIATGKQISVREFVTLSAIEAGIELEFTGKGLDEIATVKSITGDNAPALKVGDVIVKVDPRYFRPAEVET
LLGDPSKAKEKLGWTPEITVEEMCAEMVTNDLQKAKQHAILQAHGFKVNVSVES

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=352, Percent_Identity=60.5113636363636, Blast_Score=435, Evalue=1e-122,
Organism=Escherichia coli, GI1788366, Length=372, Percent_Identity=78.2258064516129, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI48994969, Length=300, Percent_Identity=28.3333333333333, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788353, Length=258, Percent_Identity=25.968992248062, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786974, Length=349, Percent_Identity=23.7822349570201, Blast_Score=61, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17507723, Length=353, Percent_Identity=63.4560906515581, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI133901788, Length=351, Percent_Identity=62.1082621082621, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17539424, Length=351, Percent_Identity=62.1082621082621, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI133901786, Length=351, Percent_Identity=62.1082621082621, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17539422, Length=351, Percent_Identity=62.1082621082621, Blast_Score=459, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI133901790, Length=351, Percent_Identity=62.1082621082621, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24158427, Length=361, Percent_Identity=56.786703601108, Blast_Score=435, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 42301; Mature: 42170

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNKVALITGVTGQDGSYLAELLLEKGYEVHGIKRRSSSLNTERVDHIYEDNHEQNQKF
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHCCCCCCCCEE
FLHYGDLTDSSNLTRIINDVQPDELYNLGAQSHVAVSFECPEYTADVDAMGTLRLLEAIR
EEEECCCCCCCCHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
FLGLEKKTKFYQASTSELFGEVQEIPQKETTPFHPRSPYGVAKMYAYWIVVNYRESYGMY
HHCCCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEEEEECCCCCEE
ACNGILFNHESPRRGETFVTRKITRAIANISQGFEKCLYLGNMDALRDWGHAKDYVRMQW
EECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHH
MMLQQETADDFVIATGKQISVREFVTLSAIEAGIELEFTGKGLDEIATVKSITGDNAPAL
HHHHHCCCCCEEEECCCEEEHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCE
KVGDVIVKVDPRYFRPAEVETLLGDPSKAKEKLGWTPEITVEEMCAEMVTNDLQKAKQHA
EECCEEEEECCCCCCCCHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ILQAHGFKVNVSVES
HEEECCEEEEEEECC
>Mature Secondary Structure 
TQNKVALITGVTGQDGSYLAELLLEKGYEVHGIKRRSSSLNTERVDHIYEDNHEQNQKF
CCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHCCCCCCCCEE
FLHYGDLTDSSNLTRIINDVQPDELYNLGAQSHVAVSFECPEYTADVDAMGTLRLLEAIR
EEEECCCCCCCCHHHHHHCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
FLGLEKKTKFYQASTSELFGEVQEIPQKETTPFHPRSPYGVAKMYAYWIVVNYRESYGMY
HHCCCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEEEEECCCCCEE
ACNGILFNHESPRRGETFVTRKITRAIANISQGFEKCLYLGNMDALRDWGHAKDYVRMQW
EECEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHH
MMLQQETADDFVIATGKQISVREFVTLSAIEAGIELEFTGKGLDEIATVKSITGDNAPAL
HHHHHCCCCCEEEECCCEEEHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCE
KVGDVIVKVDPRYFRPAEVETLLGDPSKAKEKLGWTPEITVEEMCAEMVTNDLQKAKQHA
EECCEEEEECCCCCCCCHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ILQAHGFKVNVSVES
HEEECCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8932701 [H]