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The map label for this gene is pyrB [H]

Identifier: 119899751

GI number: 119899751

Start: 3799380

End: 3800339

Strand: Direct

Name: pyrB [H]

Synonym: azo3462

Alternate gene names: 119899751

Gene position: 3799380-3800339 (Clockwise)

Preceding gene: 119899750

Following gene: 119899752

Centisome position: 86.82

GC content: 66.35

Gene sequence:

>960_bases
ATGCGTAATCCCCAGCTCAACGAACACGGCGAACTGCAACACCTGCTGACGCTGGACGGACTGCCGCGCCAGATCATTAC
CGCCATCCTCGACACCGCTGCGCCCTTCACCGAGGTCGCCGAGCGCGAGGTGAAGAAGCTGCCGCTGCTGCGCGGCAAGA
GCGTGTTCAACCTGTTCTTCGAGAACTCCACGCGCACCCGCACCACCTTCGAGATCGCGGCCAAGCGGCTTTCGGCCGAC
GTGGTGAACCTCAACATCGCCACCAGCTCGTCGAACAAGGGTGAAAGCCTGCTCGACACGGTCGATAACCTGTCGGCGAT
GCAGGCCGACATGTTCGTGGTGCGCCACGCCGCCAGCGGCGCGCCTTTCCTGATCGCGCAGCACCTGCTCGCGACCGGGC
GCGACCACATCCGCGTGGTCAATGCCGGCGACGGCCGCCATGCGCACCCCACGCAGGGCCTGCTGGACATGTACACCATC
CGCCACTACAAGGGCGACTTCACCAACCTGGTGGTGGCGATCGTCGGCGACGTGCTGCATTCCCGCGTCGCGCGCTCGCA
GATCGCCGCGCTGACCACGCTGGGCGTGCCCGAAGTGCGTGTGATCGGCCCCAAGACGCTGCTCCCCACCGAGGTCGAGC
GCATGGGCGTGCGCGTCTTCCACGACATGCGCGAGGGCCTGAAGGACGTTGACGTGGTGATGATGCTGCGGCTGCAGAAC
GAACGCATGAACGGCGCGCTGCTGCCCACGCCGCAGGAGTACTACAAGATCTGGGGCCTCACCGCCGAAAAGCTCGCGCT
CGCCAAACCCGACGCCATCGTCATGCACCCGGGGCCGATGAACCGCGGTGTGGAGATCGACTCCGCGGTGGCCGACGGCA
CGCAGGCAGTGATCCTGCCGCAGGTCACCTTCGGCATCGCCGTCCGGATGGCGGTGATGAGCATGCTCGGCAGCCACTGA

Upstream 100 bases:

>100_bases
GCGCGCTACTGCGCCCACACCCTGCCCGAAGCGCTGCCCGCCTCGCAGAACCTGCAACTCGAGCGCTCGCCCGAAGGCGC
TCTCGACCTGAGGCTGATCG

Downstream 100 bases:

>100_bases
TCGCGCCTCGCGGGCACAGGCCGGCCGCCTGCGCAGGGCGGCGGGCACGCGCACTCACAAGGAATCACGGATGAAGATTC
AGATCACCAACGGCCGGCTG

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRNPQLNEHGELQHLLTLDGLPRQIITAILDTAAPFTEVAEREVKKLPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSAD
VVNLNIATSSSNKGESLLDTVDNLSAMQADMFVVRHAASGAPFLIAQHLLATGRDHIRVVNAGDGRHAHPTQGLLDMYTI
RHYKGDFTNLVVAIVGDVLHSRVARSQIAALTTLGVPEVRVIGPKTLLPTEVERMGVRVFHDMREGLKDVDVVMMLRLQN
ERMNGALLPTPQEYYKIWGLTAEKLALAKPDAIVMHPGPMNRGVEIDSAVADGTQAVILPQVTFGIAVRMAVMSMLGSH

Sequences:

>Translated_319_residues
MRNPQLNEHGELQHLLTLDGLPRQIITAILDTAAPFTEVAEREVKKLPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSAD
VVNLNIATSSSNKGESLLDTVDNLSAMQADMFVVRHAASGAPFLIAQHLLATGRDHIRVVNAGDGRHAHPTQGLLDMYTI
RHYKGDFTNLVVAIVGDVLHSRVARSQIAALTTLGVPEVRVIGPKTLLPTEVERMGVRVFHDMREGLKDVDVVMMLRLQN
ERMNGALLPTPQEYYKIWGLTAEKLALAKPDAIVMHPGPMNRGVEIDSAVADGTQAVILPQVTFGIAVRMAVMSMLGSH
>Mature_319_residues
MRNPQLNEHGELQHLLTLDGLPRQIITAILDTAAPFTEVAEREVKKLPLLRGKSVFNLFFENSTRTRTTFEIAAKRLSAD
VVNLNIATSSSNKGESLLDTVDNLSAMQADMFVVRHAASGAPFLIAQHLLATGRDHIRVVNAGDGRHAHPTQGLLDMYTI
RHYKGDFTNLVVAIVGDVLHSRVARSQIAALTTLGVPEVRVIGPKTLLPTEVERMGVRVFHDMREGLKDVDVVMMLRLQN
ERMNGALLPTPQEYYKIWGLTAEKLALAKPDAIVMHPGPMNRGVEIDSAVADGTQAVILPQVTFGIAVRMAVMSMLGSH

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=312, Percent_Identity=34.6153846153846, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI2367364, Length=316, Percent_Identity=32.5949367088608, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI193204318, Length=335, Percent_Identity=32.2388059701493, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322331, Length=314, Percent_Identity=30.2547770700637, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24642586, Length=314, Percent_Identity=33.4394904458599, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.2 [H]

Molecular weight: Translated: 35002; Mature: 35002

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPQLNEHGELQHLLTLDGLPRQIITAILDTAAPFTEVAEREVKKLPLLRGKSVFNLFF
CCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHEEEEE
ENSTRTRTTFEIAAKRLSADVVNLNIATSSSNKGESLLDTVDNLSAMQADMFVVRHAASG
CCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
APFLIAQHLLATGRDHIRVVNAGDGRHAHPTQGLLDMYTIRHYKGDFTNLVVAIVGDVLH
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SRVARSQIAALTTLGVPEVRVIGPKTLLPTEVERMGVRVFHDMREGLKDVDVVMMLRLQN
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ERMNGALLPTPQEYYKIWGLTAEKLALAKPDAIVMHPGPMNRGVEIDSAVADGTQAVILP
CCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCCCCEEEEH
QVTFGIAVRMAVMSMLGSH
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNPQLNEHGELQHLLTLDGLPRQIITAILDTAAPFTEVAEREVKKLPLLRGKSVFNLFF
CCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHEEEEE
ENSTRTRTTFEIAAKRLSADVVNLNIATSSSNKGESLLDTVDNLSAMQADMFVVRHAASG
CCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
APFLIAQHLLATGRDHIRVVNAGDGRHAHPTQGLLDMYTIRHYKGDFTNLVVAIVGDVLH
CHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SRVARSQIAALTTLGVPEVRVIGPKTLLPTEVERMGVRVFHDMREGLKDVDVVMMLRLQN
HHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ERMNGALLPTPQEYYKIWGLTAEKLALAKPDAIVMHPGPMNRGVEIDSAVADGTQAVILP
CCCCCCCCCCCHHHHHHHCCCHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCCCCEEEEH
QVTFGIAVRMAVMSMLGSH
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA