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The map label for this gene is bioF [H]

Identifier: 119774576

GI number: 119774576

Start: 1749546

End: 1750703

Strand: Direct

Name: bioF [H]

Synonym: Sama_1439

Alternate gene names: 119774576

Gene position: 1749546-1750703 (Clockwise)

Preceding gene: 119774575

Following gene: 119774577

Centisome position: 40.63

GC content: 57.43

Gene sequence:

>1158_bases
ATGAATCGGTTGCTGCATCGCCTGGCTGAGGCCAGAGTGAAAGCCGAATCGGCGGGGCTTTGGCGTCAACGTCAGCGCCA
CAGCCCGGCTCTGATGGATTTTTCTGCCAACGATTATCTGGGGCTTGCCCGGGACGAGAGACTCGCCGAGGCCTTGGCAG
AGGGGGCCCGTCGTTATGGTGTCGGCAGTGGTGCATCGCCACTGGTGAGTGGCTACTCAGAGGCCCATGCCGAGCTGGAA
GCAGCCCTCTGCGCCGCAACCGGCCATGAAGCTGCGCTGCTCTTTTGCTCGGGCTTTGCCGCCAACCTGGCTTTGTGTCA
TGCCCTGTTTGACAGCACCGACACCCTGGTGGCCGATAAGCTTATTCATGCCTCCATGATTGACGGTATTCTTGGCAGTG
GTGCCAACCTCAAACGCTACCCACATTGTGACCTCAGTGGCGCGGCCCGCCTGATAGAGAGGTTCCCGGGTACTGCGCTT
CTCACCGAGAGTATTTTCAGCATGGATGGCGACCTGGCGCCTTTGTTACCACTCTCCAATCTGTGTGAGTCCCATAACAG
TTTGTTTATTGTCGACGACGCCCATGGGTTTGGCGTTATCGGAGAGCAAGCTATGGGTGCCAGCAGGTTGGATGGGGTGA
ATATCTCGCTCCAGCTGGTGACCTTTGGTAAGGCTCTGGGGTGCCAAGGCGCTGCGGTGCTTGGCAGTCAGGCGCTTATT
GAGAGTCTGGTGGCAAGCGCCAGGCATTATATTTATTCCACGGCGTTATCCCCTGCTCAGGCCCATGCAGCTCGCGTGTC
GCTCTCTCTGGTTCAGCAGGGGGAAAAAAGCGCAACACTGGCCGTGAATATCCGCCACTTCCTGAACTGCGCCAAGGAAG
TCGGCCTTGCTTTGCTGCCCTCTCAAAGCCCAATTCAACTGATGCCCGTCCCTACTGTACAGGCTTGCCTGATGGCAGCG
GATACTCTCAAGGCCCGAGGCTTTTTGGTGGGGGCAATTCGTCCCCCAACGGTGCCGGCACCTAGGCTCAGAATAACCCT
GAGTGCCGCCCAAAGCATGAACAGTATAGAGGCATTGGTAAACGCTCTGGCGGACATTGAAAAAGGCTTTGGCGAGGGCG
TTAACGAATGCGTAGTCAAAGGCAGTGATAAGCCATGA

Upstream 100 bases:

>100_bases
GCCGTGGTGGCGCGGGCAGCCAGGGAGCAACAGGCTGAGGGCGAAGCCAAGACCAAACCGCTTTTCTACGACGCGGCCAA
CTGAGCCGGATTTACCAGTG

Downstream 100 bases:

>100_bases
CGACCCAATACGATGTGGCAGAGCACTTTTCCCGCGCTCATCAGTACGATTGCCACAACCTGCTGCAGCGATTAACCGCA
AATAAACTGTTGACCAAGGC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MNRLLHRLAEARVKAESAGLWRQRQRHSPALMDFSANDYLGLARDERLAEALAEGARRYGVGSGASPLVSGYSEAHAELE
AALCAATGHEAALLFCSGFAANLALCHALFDSTDTLVADKLIHASMIDGILGSGANLKRYPHCDLSGAARLIERFPGTAL
LTESIFSMDGDLAPLLPLSNLCESHNSLFIVDDAHGFGVIGEQAMGASRLDGVNISLQLVTFGKALGCQGAAVLGSQALI
ESLVASARHYIYSTALSPAQAHAARVSLSLVQQGEKSATLAVNIRHFLNCAKEVGLALLPSQSPIQLMPVPTVQACLMAA
DTLKARGFLVGAIRPPTVPAPRLRITLSAAQSMNSIEALVNALADIEKGFGEGVNECVVKGSDKP

Sequences:

>Translated_385_residues
MNRLLHRLAEARVKAESAGLWRQRQRHSPALMDFSANDYLGLARDERLAEALAEGARRYGVGSGASPLVSGYSEAHAELE
AALCAATGHEAALLFCSGFAANLALCHALFDSTDTLVADKLIHASMIDGILGSGANLKRYPHCDLSGAARLIERFPGTAL
LTESIFSMDGDLAPLLPLSNLCESHNSLFIVDDAHGFGVIGEQAMGASRLDGVNISLQLVTFGKALGCQGAAVLGSQALI
ESLVASARHYIYSTALSPAQAHAARVSLSLVQQGEKSATLAVNIRHFLNCAKEVGLALLPSQSPIQLMPVPTVQACLMAA
DTLKARGFLVGAIRPPTVPAPRLRITLSAAQSMNSIEALVNALADIEKGFGEGVNECVVKGSDKP
>Mature_385_residues
MNRLLHRLAEARVKAESAGLWRQRQRHSPALMDFSANDYLGLARDERLAEALAEGARRYGVGSGASPLVSGYSEAHAELE
AALCAATGHEAALLFCSGFAANLALCHALFDSTDTLVADKLIHASMIDGILGSGANLKRYPHCDLSGAARLIERFPGTAL
LTESIFSMDGDLAPLLPLSNLCESHNSLFIVDDAHGFGVIGEQAMGASRLDGVNISLQLVTFGKALGCQGAAVLGSQALI
ESLVASARHYIYSTALSPAQAHAARVSLSLVQQGEKSATLAVNIRHFLNCAKEVGLALLPSQSPIQLMPVPTVQACLMAA
DTLKARGFLVGAIRPPTVPAPRLRITLSAAQSMNSIEALVNALADIEKGFGEGVNECVVKGSDKP

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=376, Percent_Identity=30.5851063829787, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI83977442, Length=376, Percent_Identity=29.7872340425532, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI83977440, Length=376, Percent_Identity=29.7872340425532, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI83977444, Length=376, Percent_Identity=29.7872340425532, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=31.1614730878187, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4502025, Length=319, Percent_Identity=29.7805642633229, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI40316939, Length=319, Percent_Identity=29.7805642633229, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=27.8688524590164, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI119220554, Length=383, Percent_Identity=23.7597911227154, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI5454084, Length=243, Percent_Identity=24.2798353909465, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=43.1754874651811, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=32.4858757062147, Blast_Score=147, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71994529, Length=349, Percent_Identity=31.5186246418338, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=25.0696378830084, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=25.0696378830084, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32566772, Length=375, Percent_Identity=24.8, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71982617, Length=272, Percent_Identity=21.6911764705882, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982625, Length=272, Percent_Identity=21.6911764705882, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320438, Length=387, Percent_Identity=28.1653746770026, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=24.8633879781421, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323954, Length=231, Percent_Identity=24.6753246753247, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24662918, Length=350, Percent_Identity=30, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI17137420, Length=360, Percent_Identity=25.5555555555556, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17136286, Length=367, Percent_Identity=26.4305177111717, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24653280, Length=275, Percent_Identity=23.6363636363636, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24653276, Length=275, Percent_Identity=23.6363636363636, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24653278, Length=275, Percent_Identity=23.6363636363636, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 40427; Mature: 40427

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLLHRLAEARVKAESAGLWRQRQRHSPALMDFSANDYLGLARDERLAEALAEGARRYG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCC
VGSGASPLVSGYSEAHAELEAALCAATGHEAALLFCSGFAANLALCHALFDSTDTLVADK
CCCCCCHHHHCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHH
LIHASMIDGILGSGANLKRYPHCDLSGAARLIERFPGTALLTESIFSMDGDLAPLLPLSN
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHH
LCESHNSLFIVDDAHGFGVIGEQAMGASRLDGVNISLQLVTFGKALGCQGAAVLGSQALI
HHHCCCCEEEEECCCCCCCCCHHHCCCCCCCCCCEEEEEEEECHHHCCCCHHHHHHHHHH
ESLVASARHYIYSTALSPAQAHAARVSLSLVQQGEKSATLAVNIRHFLNCAKEVGLALLP
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCEEECC
SQSPIQLMPVPTVQACLMAADTLKARGFLVGAIRPPTVPAPRLRITLSAAQSMNSIEALV
CCCCCEEECCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHH
NALADIEKGFGEGVNECVVKGSDKP
HHHHHHHHHHCCCHHHHHCCCCCCC
>Mature Secondary Structure
MNRLLHRLAEARVKAESAGLWRQRQRHSPALMDFSANDYLGLARDERLAEALAEGARRYG
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCC
VGSGASPLVSGYSEAHAELEAALCAATGHEAALLFCSGFAANLALCHALFDSTDTLVADK
CCCCCCHHHHCHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHH
LIHASMIDGILGSGANLKRYPHCDLSGAARLIERFPGTALLTESIFSMDGDLAPLLPLSN
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHH
LCESHNSLFIVDDAHGFGVIGEQAMGASRLDGVNISLQLVTFGKALGCQGAAVLGSQALI
HHHCCCCEEEEECCCCCCCCCHHHCCCCCCCCCCEEEEEEEECHHHCCCCHHHHHHHHHH
ESLVASARHYIYSTALSPAQAHAARVSLSLVQQGEKSATLAVNIRHFLNCAKEVGLALLP
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCEEECC
SQSPIQLMPVPTVQACLMAADTLKARGFLVGAIRPPTVPAPRLRITLSAAQSMNSIEALV
CCCCCEEECCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHH
NALADIEKGFGEGVNECVVKGSDKP
HHHHHHHHHHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA