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The map label for this gene is kefC [H]

Identifier: 119774529

GI number: 119774529

Start: 1682761

End: 1684686

Strand: Direct

Name: kefC [H]

Synonym: Sama_1392

Alternate gene names: 119774529

Gene position: 1682761-1684686 (Clockwise)

Preceding gene: 119774528

Following gene: 119774532

Centisome position: 39.08

GC content: 57.89

Gene sequence:

>1926_bases
ATGACCGGGATTTTTCTGCAGGCCTTTGTTTACCTGCTTGCGGCTGTGCTTGCGGTGCCCCTTGCCAAACGTTTGGGGCT
GGGCTCTGTGCTCGGTTACCTGGTTGCCGGTGTGGCCATTGGGCCTTTGTTGGGGCTGGTTGGTCAGGAAACTCAAAGTA
TTCAGCATTTTGCCGAATTCGGTGTGGTGCTGATGCTGTTTCTGGTGGGGTTGGAGCTCGACGCCAAACAGCTGTGGCAG
ATGCGCCAGCGGCTCCTGGGCCTGGGTGGTTTGCAGGTGCTGCTGACCACGGGCGCAGTGGCGGGCCTGGCGCTGATTTT
GAACCAGCCGTGGCAGATAGCGCTGGCCCTTGGAATGATCTTTGCCATGTCCTCCACCGCCATCGTGCTGCAATCCTTCA
ACGAGAAGGGACTGGCTAAAACTGAAGGTGGTCGCGGTGGTTTTTCGGTGCTCCTGTTTCAGGACATTGCGGTTATTCCG
ATTCTGGCGATATTGCCGCTGTTGGCCCTCAGCGCCCCGCAGCTCGATGCCGGCCATGAGGATATGTCGCTGGTGGCTGG
TTTGCCCGCTTGGGCAAATGCGCTGGTGGTGCTTGGCGCCATCGCTGCCGTGGTGTTTGGCGGTCGCTTTTTAACAAGGC
CACTCTTTGGATACGTGGCGCGTTCAGGGCTCAGGGAAGTCTTCACTGCGGCGGCGCTGATGATGGTGATTGGTATTGCC
GCGCTCATGAGTCTGGTGGGACTGTCGCCTGCGCTGGGAACCTTTCTGGCGGGAGTGGTACTCGCCAGCAGTGAGTTTCG
CCATGAACTCGAGTCCACCATCGAGCCCTTCAAGGGGCTGTTGTTGGGGCTCTTTTTTATCACTGTGGGCGCGGGTATCG
ATTTTGAGATGCTGCTGTCGCAGTTTGCGCTGGTGCTGGGGCTGGCATTGGGCGTGATGGTGATAAAGGCGCTGGTGCTC
CTGCTGCTGGCAAAGATTTTCCGTCTATCCGGCTCTGACAAGTGGCTGTTTGCGCTGTCGCTGGCACAGGCCGGGGAATT
TGGCTTTGTGCTGCTGGGCTACAGTCAGCAACAGGGTATCTTTGGCAGCGAGCTTGGCGGGCTTCTTTCCATGGTGGTGG
CCCTCAGTATGTTTTTAACCCCGGGGCTCTTTATCCTGTATGAACGGATTATCCTGCCGAGAGTGACCCGCAGTACCAAT
GAACGTGAAGCCGATACCATAGATGAGCAGGGGCCGGTGATCATTGCGGGCATAGGCCGCTTTGGGCAGATAGTTAACCG
CCTTTTGCGGGCCAACGGGGTGAAAACCGTGGTACTCGACCGCGAATATGCCCAGGTGGAACGACTGCGTGAAATCGAGA
TGAAGAGCTTTTTCGGGGATGTGAGTAACCCGGAGCTTTTACATACCGCGGGTATTGAGTCGGCCAAGATGCTGGTGGTG
GCCATCGATGATGTGGAAGGGGCCACAGCGCTTGTGCGCCACGTTCGCCAACAATATCCGCAGGTGGCTATTCTGGCCCG
GGCCTTTGACAGAGGGCACTTTTATGCGCTGACCGAAGCCGGTGCCGACTGGGTGGTGAGCGAGAGCTTCTACTCGGCGC
TTAACATGGGAGGCGAGGCGCTGATACGCCTTGGTATGCATCCCTTTGCCGCCGAGCAGCGCAAAACGGCTATGGTGGAG
CGGGAAAAAGCCCATGCAAGCGAGCTCTATGACGCCTGGCTTGAGGTGCGGGATAATATCGACCGCCGCGAGCGCTATTT
GAAGTTATTCATCAAGTTGGAGGAGGCGCTCAAGGAGGATATGGGTAAGGACAGGATGGATGGCCATAGCCGCAGCTTGA
GTGGCTGGACACCGCCGCCCAAGGGGTATGACAAGGCGTTGGCTGAGCAGGAGGAGAGCATGCGCCCTCAAGGTGCAAAG
GATTGA

Upstream 100 bases:

>100_bases
ATCTCGCGCGGTGGCGACAGCTGCTGGAAGCGCTGGTGGCTGGTGAAATACCGGATACCGCTTGTGGGGCTGGGGTACCG
GCAAAGCGGGAGACCTTGTC

Downstream 100 bases:

>100_bases
TGTGGGTTGGGCAAGTGATGCCCGGGCCTTAACACAAGAAAGCCGGACTCAGTCCGGCTTTTTGCATTCTTGCAGGAGGC
GCAAAAAAAACTCGCTGCCC

Product: putative TrkA family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MTGIFLQAFVYLLAAVLAVPLAKRLGLGSVLGYLVAGVAIGPLLGLVGQETQSIQHFAEFGVVLMLFLVGLELDAKQLWQ
MRQRLLGLGGLQVLLTTGAVAGLALILNQPWQIALALGMIFAMSSTAIVLQSFNEKGLAKTEGGRGGFSVLLFQDIAVIP
ILAILPLLALSAPQLDAGHEDMSLVAGLPAWANALVVLGAIAAVVFGGRFLTRPLFGYVARSGLREVFTAAALMMVIGIA
ALMSLVGLSPALGTFLAGVVLASSEFRHELESTIEPFKGLLLGLFFITVGAGIDFEMLLSQFALVLGLALGVMVIKALVL
LLLAKIFRLSGSDKWLFALSLAQAGEFGFVLLGYSQQQGIFGSELGGLLSMVVALSMFLTPGLFILYERIILPRVTRSTN
EREADTIDEQGPVIIAGIGRFGQIVNRLLRANGVKTVVLDREYAQVERLREIEMKSFFGDVSNPELLHTAGIESAKMLVV
AIDDVEGATALVRHVRQQYPQVAILARAFDRGHFYALTEAGADWVVSESFYSALNMGGEALIRLGMHPFAAEQRKTAMVE
REKAHASELYDAWLEVRDNIDRRERYLKLFIKLEEALKEDMGKDRMDGHSRSLSGWTPPPKGYDKALAEQEESMRPQGAK
D

Sequences:

>Translated_641_residues
MTGIFLQAFVYLLAAVLAVPLAKRLGLGSVLGYLVAGVAIGPLLGLVGQETQSIQHFAEFGVVLMLFLVGLELDAKQLWQ
MRQRLLGLGGLQVLLTTGAVAGLALILNQPWQIALALGMIFAMSSTAIVLQSFNEKGLAKTEGGRGGFSVLLFQDIAVIP
ILAILPLLALSAPQLDAGHEDMSLVAGLPAWANALVVLGAIAAVVFGGRFLTRPLFGYVARSGLREVFTAAALMMVIGIA
ALMSLVGLSPALGTFLAGVVLASSEFRHELESTIEPFKGLLLGLFFITVGAGIDFEMLLSQFALVLGLALGVMVIKALVL
LLLAKIFRLSGSDKWLFALSLAQAGEFGFVLLGYSQQQGIFGSELGGLLSMVVALSMFLTPGLFILYERIILPRVTRSTN
EREADTIDEQGPVIIAGIGRFGQIVNRLLRANGVKTVVLDREYAQVERLREIEMKSFFGDVSNPELLHTAGIESAKMLVV
AIDDVEGATALVRHVRQQYPQVAILARAFDRGHFYALTEAGADWVVSESFYSALNMGGEALIRLGMHPFAAEQRKTAMVE
REKAHASELYDAWLEVRDNIDRRERYLKLFIKLEEALKEDMGKDRMDGHSRSLSGWTPPPKGYDKALAEQEESMRPQGAK
D
>Mature_640_residues
TGIFLQAFVYLLAAVLAVPLAKRLGLGSVLGYLVAGVAIGPLLGLVGQETQSIQHFAEFGVVLMLFLVGLELDAKQLWQM
RQRLLGLGGLQVLLTTGAVAGLALILNQPWQIALALGMIFAMSSTAIVLQSFNEKGLAKTEGGRGGFSVLLFQDIAVIPI
LAILPLLALSAPQLDAGHEDMSLVAGLPAWANALVVLGAIAAVVFGGRFLTRPLFGYVARSGLREVFTAAALMMVIGIAA
LMSLVGLSPALGTFLAGVVLASSEFRHELESTIEPFKGLLLGLFFITVGAGIDFEMLLSQFALVLGLALGVMVIKALVLL
LLAKIFRLSGSDKWLFALSLAQAGEFGFVLLGYSQQQGIFGSELGGLLSMVVALSMFLTPGLFILYERIILPRVTRSTNE
READTIDEQGPVIIAGIGRFGQIVNRLLRANGVKTVVLDREYAQVERLREIEMKSFFGDVSNPELLHTAGIESAKMLVVA
IDDVEGATALVRHVRQQYPQVAILARAFDRGHFYALTEAGADWVVSESFYSALNMGGEALIRLGMHPFAAEQRKTAMVER
EKAHASELYDAWLEVRDNIDRRERYLKLFIKLEEALKEDMGKDRMDGHSRSLSGWTPPPKGYDKALAEQEESMRPQGAKD

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=402, Percent_Identity=26.6169154228856, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1786232, Length=636, Percent_Identity=43.8679245283019, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1789749, Length=621, Percent_Identity=41.3848631239936, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1786685, Length=516, Percent_Identity=28.4883720930233, Blast_Score=168, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 69357; Mature: 69225

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGIFLQAFVYLLAAVLAVPLAKRLGLGSVLGYLVAGVAIGPLLGLVGQETQSIQHFAEF
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GVVLMLFLVGLELDAKQLWQMRQRLLGLGGLQVLLTTGAVAGLALILNQPWQIALALGMI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FAMSSTAIVLQSFNEKGLAKTEGGRGGFSVLLFQDIAVIPILAILPLLALSAPQLDAGHE
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DMSLVAGLPAWANALVVLGAIAAVVFGGRFLTRPLFGYVARSGLREVFTAAALMMVIGIA
HHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALMSLVGLSPALGTFLAGVVLASSEFRHELESTIEPFKGLLLGLFFITVGAGIDFEMLLS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
QFALVLGLALGVMVIKALVLLLLAKIFRLSGSDKWLFALSLAQAGEFGFVLLGYSQQQGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHCCCCCEEEEECCCCCCC
FGSELGGLLSMVVALSMFLTPGLFILYERIILPRVTRSTNEREADTIDEQGPVIIAGIGR
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEEEEECHH
FGQIVNRLLRANGVKTVVLDREYAQVERLREIEMKSFFGDVSNPELLHTAGIESAKMLVV
HHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCEEEE
AIDDVEGATALVRHVRQQYPQVAILARAFDRGHFYALTEAGADWVVSESFYSALNMGGEA
EECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCHHH
LIRLGMHPFAAEQRKTAMVEREKAHASELYDAWLEVRDNIDRRERYLKLFIKLEEALKED
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
MGKDRMDGHSRSLSGWTPPPKGYDKALAEQEESMRPQGAKD
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TGIFLQAFVYLLAAVLAVPLAKRLGLGSVLGYLVAGVAIGPLLGLVGQETQSIQHFAEF
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH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CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA